Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030794 (pelvic pain)
 4,056 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Chemotherapy-induced neuropathy (CIN) has limited treatment options, and conventional medications used to treat neuropathic pain often do not provide adequate pain relief for patients with a history of cancer. Neuromodulation such as dorsal root ganglion stimulation (DRGS) remains a treatment that has been studied for chronic painful conditions such as low back pain, pelvic pain, complex regional pain syndrome, and phantom limb pain. DRGS have been presented for treatment of CIN, but with limited duration of follow up. We present a case of pain resolution after placement of a DRGS for persistent chemotherapy-induced neuropathy. Our patient developed burning pain and allodynia in both feet 3 months into her chemotherapy regimen, with worsened symptoms after cessation of chemotherapy. After failure of conservative pharmacotherapies, a 7 day trial DRGS was implanted (Figure 1), resulting in 100% pain relief. A DRGS was then implanted permanently, and our patient reported continued resolution of symptoms at evaluation 3 years after placement. To the author's knowledge, this is the first case of sustained relief with DRGS placement for chemotherapy-induced neuropathy and presents a treatment option that warrants further investigation.
 ...
PMID:Dorsal Root Ganglion Stimulation for Treatment of Chemotherapy-Induced Neuropathy: A Case Report. 3270 35