Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030794 (pelvic pain)
 4,056 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four cases of endocervicosis that involved the outer cervical wall and paracervical connective tissue are reported; in one case there was also transmural involvement of the urinary bladder. A diagnosis of cervical adenocarcinoma was an initial concern of the referring pathologist in three cases. The patients were from 29 to 45 years of age; there was a history of cesarean section in two cases. Two patients presented with pelvic pain, one with dysmenorrhea, and one with symptoms related to an ovarian tumor. In three cases, a gross abnormality of the outer aspect of the cervix was noted at the time of hysterectomy and in the fourth at the time of macroscopic pathologic examination. The anterior wall of the cervix in each case was involved by a firm rubbery mass, 1 to 2.5 cm in maximal dimension, with cysts seen on sectioning in two. Microscopic examination disclosed a dominant population of glands of variable size and shape, including cystically dilated glands, lined by mucinous endocervical-type epithelium that ranged from columnar to flattened. All the glands had lining cells with bland cytologic features with absent to rare mitotic figures. A periglandular stromal reaction, present in two cases, was related to mucin extravasation. A cuff of endometriotic stroma was present around rare glands in one case. The appearance of the lesion was similar to that of endocervicosis of the urinary bladder, and as in that site, raised concern for adenocarcinoma, specifically for the minimal deviation (adenoma malignum) type of cervical adenocarcinoma. Awareness of the distinctive features of endocervicosis in this site, including its dominant location in the outer portion of the cervix and paracervical connective tissue and the typical presence of an uninvolved zone of cervical wall between the endocervicosis and the eutopic endocervical glands, facilitate the correct diagnosis.
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PMID:Endocervicosis involving the uterine cervix: a report of four cases of a benign process that may be confused with deeply invasive endocervical adenocarcinoma. 1110 60

In the last few years, an enormous progress has been achieved in the treatment of Colorectal Cancer due to a better know ledge of the biology, natural history, prevention and treatment of colon and rectum adenocarcinoma. Genetic alterations produce changes in thecolonic mucosa that lead to the formation of adenoma and eventually, its transformation into cancer. At present, it is well established that the Adenomatous Polyp preceeds Colorectal Cancer. The average span of time from normal mucosa to Adenomatous Polyp is about 5 years, and it takes around 5 more years for the Adenomatous Polyp to transform into cancer. The treatment of patients with Colorectal Cancer varies from Endoscopic Polypectomy or formal surgical resection to combined multidisciplinary strategies, according with the stage of the disease. Endoscopic Polypectomy has helped to avoid multiple operations that were performed in the past, it also reduces significantly the development of a second cancer in cured patients who had suffered Colon Cancer. The prognosis of node-negative patients is excellent with a 5 year survival of 80 per cent. Adjuvant chemotherapy has proven to be effective in node-positive Colon Cancer, improving the overall survival. In Rectum Cancer, the use of staplers and changes in the surgical technique have reduced the number of abdominoperineal resections, preserving the annal sphincter and improving the quality of life in patients. Adjuvant chemoradiation control groups and historical controls show a local recurrence of 20-45 per cent in node-positive Rectum Cancer, and 15-30 per cent in node-negative patients. Recently, the improvement of the lateral dissection reduces recurrence in 10 per cent, avoiding pelvic pain, although overall survival has not been improved. Local excision of early lesions from the rectum is an interesting choice in patients who have been carefully selected. We believe that in the following years, the clinical appearance of Colorectal Cancer can be prevented with a better knowledge of its molecular biology.
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PMID:[COLON AND RECTUM CANCER SURGERY] 1227 38

Inflammatory diseases of the prostate are common among men. These diseases are frequently characterized by long-term course and relapses. Prostatitis-associated symptoms significantly reduce the quality of life of patients. Due to the lack of generally accepted criteria for the diagnosis of prostatitis, the frequency of inflammatory diseases of the prostate is difficult to establish. Inflammatory diseases of the prostate should be differentiated from chronic pelvic pain syndrome. The mainstay of treatment of infectious and inflammatory processes in the prostate are antibacterial drugs (generations III and IV fluoroquinolones). The recommended course of treatment includes 4-6 weeks. Prostate peptides from bovine (cytomedines) have proven efficacy in the treatment of patients with prostatitis; cytomedines influence the differentiation and proliferation of prostate cells, have anti-inflammatory and immunomodulatory properties. In clinical trials, high efficiency of cytomedines in prostatitis and prostate adenoma, as well as long-term remission of the diseases is demonstrated.
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PMID:[The use of vitaprost in the treatment of patients with prostate diseases]. 2477 77