Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.05 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
LOC644246 9.0
GIGYF2 protein 9.0
transmembrane protein 175 9.0
musashi 1 9.0
DRD5P2 9.0
TOMM7 9.0
tyrosine hydroxylase isoform 2 9.0
FAM171A2 9.0
peroxisomal biogenesis factor 3 9.0
F-box only protein 48 9.0
DENND2A 9.0
bridging integrator 3 9.0
CDCP2 9.0
DRD5P1 9.0
signal peptide peptidase-like 2B 9.0
Roco1 9.0
AMPK beta 1 9.0
metallopeptidase M20 family 9.0
FLJ45455 9.0
FLJ43860 9.0
RAB7, member RAS oncogene family-like 1 9.0
Coiled-coil domain-containing protein 154 9.0
C2orf58 9.0
OR52L1 9.0
PTPDC1 9.0
OR9A2 9.0
discs, large (Drosophila) homolog-associated protein 3 9.0
zinc finger with KRAB and SCAN domains 3 9.0
Cytogaligin 9.0
synphilin-1A 9.0
FLJ35379 9.0
ZCRB1 9.0
neuron specific transcription factor 9.0
DHX57 9.0
non-SMC condensin I complex, subunit D2 9.0
PRR18 9.0
ZSCAN21 9.0
FGF20 protein 9.0
KIAA1024L 9.0
serine/threonine kinase 32B 9.0
nuclear undecaprenyl pyrophosphate synthase 1 homolog 9.0
C20orf24 9.0
LRRC37A2 9.0
ZSCAN21 protein 9.0
CENTB5 9.0
centaurin beta5 9.0
Cyclin G associated kinase 9.0
EFHA2 9.0
EIF4G1 protein 9.0
Parkinson disease (autosomal recessive, juvenile) 2, parkin 9.0
Neurofilament-light 9.0
DnaJ (Hsp40) homolog, subfamily C, member 13 9.0
parkin isoform 9.0
PARK8 8.9
leucine-rich repeat kinase 2 8.9
Leucine-rich repeat kinase 2 8.9
ZNF746 8.8
LRRK2 8.8
Synphilin-1 8.8
SNCA 8.7
synphilin-1 8.7
DNAJC13 8.7
Alpha synuclein 8.6
RAB7L1 8.6
zinc finger protein 746 8.6
Dopamine receptor D3 8.6
Synaptotagmin XI 8.6
alpha-synuclein 8.5
PARK6 8.5
parkin 8.5
alpha synuclein 8.5
synuclein 8.5
ATP13A2 8.5
Kufor-Rakeb syndrome 8.4
DCAKD 8.4
RAB29 8.4
PARK7 8.4
FBXO7 8.3
beta-synuclein 8.3
SYT11 8.3
more...
Disease
Autosomal Recessive Parkinsonism 9.0
Other extrapyramidal and movement disorders 9.0
Parkinson's disease 9.0
Manic psychosis 9.0
PARK10 9.0
Pallidonigral degeneration 9.0
Other degenerative diseases of the basal ganglia 9.0
cortex; degeneration 9.0
Explosive diarrhea 9.0
Extracampine hallucinations 9.0
Impairment of attention 9.0
PARK12 9.0
Other mental retardation 9.0
Specific disorders of sleep 9.0
Genetic Brain Disorders 9.0
pathological emotionality 9.0
PARK4 9.0
Behavioral and emotional disorders with onset usually occurring in childhood and adolescence 9.0
PARK8 9.0
PARK1 8.9
PARK13 8.9
PARK5 8.8
PARK3 8.8
Hypokinetic dysarthria 8.8
PARK6 8.7
PARK11 8.6
Parkinson-dementia complex of Guam 8.5
Parkinsonian crisis 8.4
Drug-induced dyskinesia 8.4
PARK7 8.4
Juvenile Parkinsonism 8.3
Sleep attacks 8.3
Parkinson's disease and parkinsonism 8.3
PARK2 8.2
Pisa syndrome 8.2
camptocormia 8.1
REM sleep behavior disorder 8.1
abnormal involuntary movements 8.1
Dementia with Lewy bodies 8.0
impulse control disorder 8.0
Vascular parkinsonism 8.0
Primary Dystonia 8.0
ABSD 8.0
Drug-induced constipation 8.0
Motor Skills Disorders 8.0
Pallidoluysian atrophy 8.0
Familial motor neuron disease 8.0
hemiparkinsonism 7.9
Dementia in Parkinson's disease 7.8
Secondary parkinsonism 7.8
Blocq 7.8
Neurologic Diseases 7.7
KRS 7.6
Othello syndrome 7.6
Striatonigral degeneration 7.5
dyskinesia 7.5
akinesia 7.5
parkinsonism 7.5
Infrequent bowel movements 7.4
Upper motor neuron disease 7.4
Recurrent chest infections 7.4
Bradyphrenia 7.4
Thalamic infarction 7.4
CRCL 7.4
drug psychosis 7.4
Vallecula 7.4
movement disorder 7.4
Multiple system atrophy 7.4
progressive supranuclear palsy 7.3
PPND 7.2
Motor Disorders 7.2
hypersexuality 7.0
growth hormone-producing pituitary tumor 7.0
Progressing stroke 7.0
Chronic sorrow 7.0
Apraxia of gait 7.0
Eccrine hidrocystoma 7.0
Essential tremor 7.0
behavior disorder 6.9
Neurodegenerative Disorders 6.9
more...
Symptom
Persistent tremor 9.0
Cog-wheel rigidity 9.0
Other hallucinations 9.0
Pleurothotonus 9.0
dribbling saliva 9.0
Poverty of facial expression 9.0
motor symptom 8.6
Rest tremor 8.5
bradykinesia 8.5
Frozen gait 8.4
Parkinsonian rest tremor 8.3
Antecollis 8.2
Ballismus 8.0
Hypometria 8.0
posthemiplegic chorea 8.0
Parkinsonian tremor 7.6
Postural tremor 7.5
Leg discomfort 7.4
Senile tremor 7.4
Gustatory rhinorrhea 7.4
visual hallucination 7.1
Limb dystonia 7.0
Retropulsion 6.9
Primary orthostatic tremor 6.7
amimia 6.7
impaired body balance 6.7
tremor 6.6
tactile hallucination 6.4
muscle rigidity 6.3
Motor dysfunction 6.2
Swallowing problems 6.0
dystonia 6.0
Involuntary Movement 6.0
abnormal gait 5.9
Respiratory dyskinesia 5.7
Tandem gait 5.7
apathy 5.6
drooling 5.5
feeling faint 5.4
intention tremor 5.4
Urinary symptoms 5.3
Behavioral symptoms 5.2
Hyposensitivity 5.2
chorea 5.2
Extrapyramidal symptoms 5.1
SYMPTOMS 5.1
Convulsive seizure 5.1
athetosis 5.0
Fear of falling 5.0
Fear of falling 5.0
disturbed speech 5.0
mirror writing 4.9
Ankle stiffness 4.8
dysosmia 4.8
dysarthria 4.8
waxy flexibility 4.7
Dribbling 4.7
impaired motor coordination 4.7
blepharospasm 4.6
Cardiovascular symptoms 4.6
Respiratory abnormalities 4.6
Circling 4.6
Urge incontinence 4.5
eds 4.5
Pyramidal signs 4.4
Hemiballism 4.4
Psychiatric symptoms 4.3
Stepping 4.3
anosmia 4.3
Central pain 4.3
Hyperflexion 4.3
pain in the buttock 4.3
Decreased activity 4.2
lightheadedness 4.2
sleepiness 4.2
Visual symptoms 4.2
disturbed balance 4.1
upset stomach 4.1
constipation 4.1
loss of balance 4.1
more...
Drug
Dopascan 9.0
D-CS 9.0
Mazapertine succinate 9.0
Etilevodopa 9.0
Emsam 9.0
Quinpirole hydrochloride 9.0
Comtan 8.8
Mirapex 8.7
Istradefylline 8.6
Eldepryl 8.6
Permax 8.5
Permax 8.5
Rotigotine 8.4
Eldepryl 8.4
Rasagiline 8.4
Tasmar 8.4
Lazabemide 8.3
Droxidopa 8.3
Sinemet 8.2
Sinemet 8.2
Pramipexole 8.2
Pramipexole 8.1
Madopar 8.1
Azilect 8.1
Benserazide hydrochloride 8.0
Parkin 8.0
Parkin 7.9
DBS 7.7
Zydis 7.7
3,4-Dihydroxyphenylalanine 7.6
Requip 7.5
Requip 7.5
EMD 128130 7.4
Lergotrile mesylate 7.4
Sinemet 7.4
Carbidopa 7.2
Flunarizine hydrochloride 7.0
Disipal 7.0
Benserazide 6.8
Rose oil 6.8
Lisuride 6.8
Apomorphine hydrochloride 6.8
Fluvoxamine maleate 6.8
Dioscorea rhizome 6.7
Terguride 6.6
Lergotrile 6.5
Brocresine 6.4
Haloperidol Decanoate 6.4
Apomorphine 6.4
Glyceryl behenate 6.2
Disipal 6.2
Artane 6.0
Fluvoxamine maleate 6.0
Artane 6.0
Akineton 6.0
Succinobucol 6.0
Bextra 5.8
Bupleurum root 5.8
Axokine 5.8
Aminoadamantane 5.8
Bifeprunox 5.7
Zonisamide 5.6
Tandetron 5.5
Nitecapone 5.5
Clopenthixol 5.4
Alsterpaullone 5.4
CFT 5.4
7-Nitroindazole 5.3
Glyceryl monostearate 5.3
Tianma 5.2
Naphtha 5.2
Exametazime 5.2
Methyltyrosine 5.2
MDS 5.1
Parlodel 5.1
Arundic acid 5.1
Manganese chloride 5.0
Fenobam 5.0
Pranoprofen 5.0
Remacemide hydrochloride 5.0
more...
Enzyme
MPP 7.8
HtrA2 protease 7.4
cysteine-S-conjugate N-acetyltransferase 7.4
neurosin 7.4
glucocerebrosidase 6.7
tyrosine hydroxylase 6.6
aromatic L-amino acid decarboxylase 6.2
Omi/HtrA2 6.1
DAT 5.8
DOPA decarboxylase 5.7
catechol O-methyltransferase 5.7
complex I 5.5
carboxypeptidase 1 5.4
nicotinamide N-methyltransferase 5.2
monoamine oxidase 5.2
GTP cyclohydrolase I 5.2
isopeptidase 5.2
rhomboid protease 5.0
proteasome ATPase 5.0
prenylated protein methyltransferase 5.0
p-hydroxyphenylacetate 3-hydroxylase 4.9
kynurenine 3-monooxygenase 4.9
ubiquitin-protein ligase 4.9
pantothenate kinase 4.8
Aeromonas proteolytica aminopeptidase 4.8
3-hydroxyisobutyryl-CoA hydrolase 4.5
CEP 4.3
cyclohydrolase 4.3
Thy1 4.2
SDMT 4.2
AIR synthetase 4.2
phosphoethanolamine cytidylyltransferase 4.0
methylmalonyl-CoA epimerase 4.0
NQO2 4.0
kynurenine aminotransferase 3.9
proteasome 3.9
CEP 3.8
sepiapterin reductase 3.8
DAP II 3.8
MT 1 3.8
kynureninase 3.7
aminocarboxymuconate-semialdehyde decarboxylase 3.7
phosphatidylserine decarboxylase 3.7
fluorinase 3.6
TMT 3.5
guanidinoacetate methyltransferase 3.4
histamine N-methyltransferase 3.4
MsrA 3.4
6-pyruvoyltetrahydropterin synthase 3.4
alpha-ketoglutarate dehydrogenase 3.4
SNO 3.4
methionine sulfoxide reductase 3.4
arogenate dehydrogenase 3.4
tyrosine decarboxylase 3.4
gamma-glutamylcysteine synthetase 3.3
GSK 3.3
GRK5 3.2
serum carnosinase 3.1
CPA2 3.1
NADH dehydrogenase 3.1
NSY 3.1
dihydropteridine reductase 3.1
CYP46A1 3.1
3-mercaptopyruvate sulfurtransferase 3.1
choline acetyltransferase 3.1
dopamine beta-hydroxylase 3.1
caspase-3 3.0
carnosinase 3.0
cholinesterase 2.9
MHCK 2.9
caspase-6 2.9
proteinase K 2.9
tryptophan hydroxylase 2.8
dihydrolipoamide succinyltransferase 2.8
caspase-6 2.8
prolyl endopeptidase 2.8
aconitase 2.8
cathepsin X 2.8
cysteine dioxygenase 2.8
IOR 2.8
more...
Compound
C9H9NO7 9.0
C20H16N2O 9.0
C20H16N2O 9.0
C20H16N2O 9.0
C20H16N2O 9.0
C20H16N2O 9.0
2-(4-methylphenyl)-1H-indole 9.0
C20H16N2O 9.0
C20H16N2O 9.0
C20H16N2O 9.0
C20H16N2O 9.0
C20H16N2O 9.0
1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione 9.0
C20H16N2O 9.0
2-(4-methylphenyl)-1H-indole 9.0
C20H16N2O 9.0
DNPD 9.0
Carbidopa-levodopa 8.6
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 8.3
Ropinirole 8.3
MPTP 8.3
Entacapone 8.3
1-benzyl-1,2,3,4-tetrahydroisoquinoline 8.3
2-benzylidene-1-indanone 8.2
Tolcapone 8.2
Selegiline 8.1
PDQ 8.1
1-Methyl-4-phenylpyridinium 8.0
C19H17NO4 8.0
C10H10ClNO2 8.0
C19H17NO4 8.0
C19H17NO4 8.0
C19H17NO4 8.0
C10H10ClNO2 8.0
C19H17NO4 8.0
C19H17NO4 8.0
C10H10ClNO2 8.0
1-benzyl-3,4-dihydroisoquinoline 8.0
C19H17NO4 8.0
C10H10ClNO2 8.0
C10H10ClNO2 8.0
4-phenylbutanamide 8.0
C19H17NO4 8.0
3,4-Dihydroxyphenylacetaldehyde 8.0
C19H17NO4 8.0
C10H10ClNO2 8.0
C10H10ClNO2 8.0
C19H17NO4 8.0
1-chloroisoquinoline 8.0
C10H10ClNO2 8.0
gamma-Fagarine 8.0
C19H17NO4 8.0
C19H17NO4 8.0
C19H17NO4 8.0
2-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 8.0
C19H17NO4 8.0
C19H17NO4 8.0
Biperiden hydrochloride 8.0
Deoxygedunin 8.0
C10H10ClNO2 8.0
C10H10ClNO2 8.0
C19H17NO4 8.0
C19H17NO4 8.0
C19H17NO4 8.0
C10H10ClNO2 8.0
MPP 7.9
MPP 7.9
Pergolide 7.8
4-phenyl-1,2,3,6-tetrahydropyridine 7.8
DBS 7.7
1-methyl-1,2,3,6-tetrahydropyridine 7.6
1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 7.4
Lycopodine 7.4
C21H19N3O3S 7.4
C19H17NO4 7.4
N-Methyl-(R)-salsolinol 7.4
C19H17NO4 7.4
2,6-dimethyl-3,5-pyridinedicarboxylic acid 7.4
N(epsilon)-(gamma-glutamyl)-lysine 7.4
2,6-dimethyl-3,5-pyridinedicarboxylic acid 7.4
more...