Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: UMLS:C0030567 (Parkinson's disease)
63,064 document(s) hit in 31,850,051 MEDLINE articles (0.04 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein synuclein 3899 Sep 3688 Mol 3068 alpha-synuclein 3009 tyrosine hydroxylase 2917 ubiquitin 1141 dopamine transporter 1006 parkin 931 Parkin 914 MRI 849 MPP 843 olfactory 837 proteasome 827 LRRK2 826 DJ-1 763 caspase-3 741 PINK1 732 amyloid precursor protein 710 ATP 702 axonal 674 MAO-B 602 leucine-rich repeat kinase 2 587 SNCA 583 prion 560 glucocerebrosidase 507 endoplasmic reticulum 504 glial cell line-derived neurotrophic factor 488 lipopolysaccharide 480 superoxide dismutase 476 brain-derived neurotrophic factor 474 GABA 472 Bcl-2 444 GSH 440 neurotrophic factor 432 gut 427 glial fibrillary acidic protein 388 cytokine 384 DBS 378 TNF 363 STN 361 tumor necrosis factor 338 catalase 334 insulin 332 ACS 326 tau protein 321 PTEN 315 inducible nitric oxide synthase 311 dopa decarboxylase 294 PARK2 293 catechol-O-methyltransferase 287 ROS 285 CIT 273 NMR 269 NMDA receptor 265 p53 256 CSF 255 cytochrome c 251 p38 237 PARK7 235 E3 ubiquitin ligase 234 mTOR 229 vesicular monoamine transporter 2 227 acetylcholinesterase 216 GTPase 211 IL-6 211 nitric oxide synthase 210 Nurr1 206 glutathione peroxidase 201 MAO-A 197 dopamine D2 receptor 190 Nrf2 186 PARKIN 183 PI3K 178 ERK1 177 ERK 177 JNK 175 REM 175 LC3 174 Pol 173 MAPK 172 more...

Disease Parkinson's disease 63064 Alzheimer's disease 9103 parkinsonism 5149 dementia 4717 depression 3187 Huntington's disease 2328 amyotrophic lateral sclerosis 2096 cognitive impairment 1970 dyskinesia 1930 stroke 1716 multiple sclerosis 1570 movement disorder 1501 schizophrenia 1490 progressive supranuclear palsy 1035 cancer 1030 epilepsy 985 diabetes 869 neuroblastoma 867 Dementia with Lewy bodies 848 psychosis 836 akinesia 830 hallucinations 751 neurological disease 560 GSH 441 sleep disorders 438 ischemia 347 abnormal involuntary movements 338 hypertension 337 tumor 316 sleep disturbances 307 dysphagia 302 major depressive disorder 299 PARK2 295 autism 290 addiction 282 catalepsy 255 restless legs syndrome 249 REM sleep behavior disorder 246 Gaucher disease 239 behavior disorder 230 cerebral ischemia 220 type 2 diabetes 218 Tourette syndrome 213 obesity 213 delusions 207 obsessive-compulsive disorder 200 CNS diseases 194 drug addiction 181 memory impairment 177 PARK7 174 HIV 172 cardiovascular disease 165 migraine 163 bipolar disorder 163 myelodysplastic syndrome 159 MDS 156 confusion 156 atherosclerosis 155 chronic pain 155 impulse control disorder 150 Creutzfeldt-Jakob disease 146 Down syndrome 146 pathological gambling 144 rheumatoid arthritis 143 brain atrophy 142 tardive dyskinesia 141 motor neuron disease 140 mental illness 138 Multiple system atrophy 138 plaque 138 incontinence 134 SCH 132 encephalopathy 131 pheochromocytoma 130 ADHD 126 osteoporosis 124 anxiety disorders 120 apraxia 120 PDD 120 glaucoma 119 more...

Symptom tremor 3558 bradykinesia 1684 dystonia 1074 pain 890 sleepiness 458 apathy 389 fatigue 386 motor symptom 360 constipation 341 ataxia 277 seizures 273 insomnia 223 functional recovery 209 dysarthria 201 anesthesia 193 nausea 192 muscle rigidity 166 weakness 153 chorea 148 abnormal gait 137 headache 116 myoclonus 113 agitation 103 dizziness 98 cerebellar ataxia 96 discomfort 95 discomfort 92 vomiting 90 spasticity 85 thinning 80 visual hallucination 79 collapse 77 memory loss 66 syncope 63 drooling 60 anosmia 60 diarrhea 53 Involuntary Movement 51 cough 50 nausea and vomiting 50 blepharospasm 49 stigma 48 starvation 48 eds 47 anorexia 46 dyspnea 46 analgesia 44 Rest tremor 39 Depressive symptoms 37 catatonia 36 Parkinsonian tremor 33 abdominal pain 32 hypertonia 31 tinnitus 29 back pain 29 intention tremor 29 hypersomnia 29 muscle stiffness 26 paresis 26 paresthesia 25 ophthalmoplegia 25 hypothermia 25 torticollis 24 regurgitation 23 spasm 23 distraction 23 low back pain 22 incoordination 22 stridor 22 vertigo 22 respiratory distress 21 Decreased activity 20 asthenia 20 exhaustion 20 hemiplegia 19 lightheadedness 19 forgetfulness 17 athetosis 17 pallor 16 overweight 16 more...

Drug Parkin 914 Parkin 914 DBS 378 ROS 285 CSF 259 caffeine 224 Apomorphine 201 Sinemet 174 MDS 155 Sinemet 141 Posture 131 lysine 130 vitamin E 129 Sinemet 127 Pramipexole 122 Pramipexole 113 NADH 106 Rasagiline 105 Spectrum 98 ascorbate 98 Frontal 97 ROC 93 Rotigotine 68 Glutathione 67 Madopar 63 BH4 56 Monit 49 CFT 49 Carbidopa 48 Dermatol 40 Zonisamide 36 L-tyrosine 31 3,4-Dihydroxyphenylalanine 30 Lisuride 29 Heme 28 MAP 27 Reserpine 27 IL-2 27 Histamine 26 Leaf 26 Eldepryl 26 ENT 26 Nephron 26 p75 25 niacin 25 HCH 23 Istradefylline 21 Azilect 21 Eldepryl 21 Tocopherol 20 TMS 20 Cardiovasc 19 ABC 19 IPD 18 PCP 17 Glucagon 16 Modafinil 16 Simvastatin 15 Domperidone 15 Vitamin E 15 IFN-gamma 15 nitroglycerin 15 citric acid 14 Droxidopa 14 Spectrum 14 ICI 13 Benserazide 12 Gel 12 EE2 12 Donepezil 12 Angiotensin II 12 Parlodel 11 Clonidine 11 Asn 11 Ginseng 11 Parlodel 10 lactose 10 Bifidobacterium 10 Ethanol 10 Indomethacin 10 more...

Enzyme tyrosine hydroxylase 2796 MPP 846 proteasome 831 complex I 817 monoamine oxidase 785 mitogen-activated protein kinase 725 superoxide dismutase 599 caspase-3 586 protein kinase 507 catalase 362 acetylcholinesterase 352 ACS 326 glucocerebrosidase 311 ERK 292 glutathione peroxidase 204 cholinesterase 191 DAT 161 ATPase 156 focal adhesion kinase 139 luciferase 136 lactate dehydrogenase 130 GSK 128 NADPH oxidase 120 NADPH oxidase 116 protein kinase C 113 PARP 108 DOPA decarboxylase 108 choline acetyltransferase 105 AMP-activated protein kinase 105 cytochrome oxidase 100 MEK 99 peroxidase 98 caspase-9 90 calcineurin 90 NO synthase 86 succinate dehydrogenase 77 aromatic L-amino acid decarboxylase 76 NQO1 76 tyrosinase 72 glutathione S-transferase 69 AMPK 68 ceruloplasmin 67 renin 66 glutathione reductase 63 phosphatidylinositol 3-kinase 63 proteinase K 59 diaphorase 55 AMPK 54 phosphodiesterase 53 phospholipase A2 50 creatine kinase 49 caspase-1 49 GTP cyclohydrolase I 48 ACE 47 aldehyde dehydrogenase 46 NOS 46 ubiquitin-protein ligase 46 Omi/HtrA2 45 Thy1 45 aldehyde dehydrogenase 45 aldehyde dehydrogenase 43 aldehyde dehydrogenase 43 aldehyde dehydrogenase 43 cathepsin D 41 glyceraldehyde-3-phosphate dehydrogenase 40 isopeptidase 40 phosphoinositide 3-kinase 40 P-glycoprotein 39 catechol O-methyltransferase 39 adenylate cyclase 38 NADH dehydrogenase 37 protein phosphatase 2A 36 ATP synthase 36 trypsin 34 heme oxygenase 34 beta-galactosidase 32 caspase-8 32 reverse transcriptase 32 glyceraldehyde-3-phosphate dehydrogenase 32 CEP 31 more...

Compound Dec 3840 MPTP 3217 L-DOPA 2869 Clin 2682 oxygen 2275 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 2040 DNA 1551 iron 1322 glutamate 1276 Dopamine 1058 calcium 1022 MPP 843 MPP 843 ATP 702 water 702 nitric oxide 641 glucose 538 tyrosine 520 hydrogen 509 GSH 486 GSH 486 GABA 478 GABA 475 manganese 454 5-HT 418 cysteine 390 DBS 378 TNF 363 copper 357 noradrenaline 349 sodium 337 ACS 326 Neuronal 326 ACS 326 NMDA 298 leucine 298 serine 297 Dopa 281 CIT 278 CIT 274 PDQ 237 zinc 235 Rotenone 233 caffeine 232 potassium 225 nitrogen 212 MTT 204 cAMP 204 phosphate 204 alanine 193 H2O2 187 methionine 186 His 184 lysine 183 threonine 179 homocysteine 162 DAT 161 Selegiline 159 DOPAC 157 tryptophan 153 arginine 152 N-acetylcysteine 146 tryptophan 146 NAD 145 sulfate 144 tryptophan 140 tryptophan 140 nicotinamide 134 3,4-dihydroxyphenylalanine 134 gamma-aminobutyric acid 134 GTP 133 Adenosine 133 Cereb 132 DSM 132 pyridine 131 Glutamate 127 AMPA 121 iodine 117 NAD 117 Paraquat 114 more...

---