Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0030567 (Parkinson's disease)
63,064 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein synuclein 3899 Sep 3688 Mol 3068 alpha-synuclein 3009 tyrosine hydroxylase 2917 ubiquitin 1141 dopamine transporter 1006 parkin 931 Parkin 914 MRI 849 MPP 843 olfactory 837 proteasome 827 LRRK2 826 DJ-1 763 caspase-3 741 PINK1 732 amyloid precursor protein 710 ATP 702 axonal 674 MAO-B 602 leucine-rich repeat kinase 2 587 SNCA 583 prion 560 glucocerebrosidase 507 endoplasmic reticulum 504 glial cell line-derived neurotrophic factor 488 lipopolysaccharide 480 superoxide dismutase 476 brain-derived neurotrophic factor 474 GABA 472 Bcl-2 444 GSH 440 neurotrophic factor 432 gut 427 glial fibrillary acidic protein 388 cytokine 384 DBS 378 TNF 363 STN 361 tumor necrosis factor 338 catalase 334 insulin 332 ACS 326 tau protein 321 PTEN 315 inducible nitric oxide synthase 311 dopa decarboxylase 294 PARK2 293 catechol-O-methyltransferase 287 ROS 285 CIT 273 NMR 269 NMDA receptor 265 p53 256 CSF 255 cytochrome c 251 p38 237 PARK7 235 E3 ubiquitin ligase 234 mTOR 229 vesicular monoamine transporter 2 227 acetylcholinesterase 216 GTPase 211 IL-6 211 nitric oxide synthase 210 Nurr1 206 glutathione peroxidase 201 MAO-A 197 dopamine D2 receptor 190 Nrf2 186 PARKIN 183 PI3K 178 ERK 177 ERK1 177 JNK 175 REM 175 LC3 174 Pol 173 MAPK 172 nerve growth factor 169 DAT 161 Leucine-rich repeat kinase 2 158 ferritin 158 heme oxygenase-1 157 MDS 155 SOD 147 prion protein 145 AKT 143 nicotinic acetylcholine receptor 142 ATPase 140 COMT 140 ubiquitin ligase 140 substance P 139 p62 139 huntingtin 137 ATP13A2 134 histone 134 TGF-beta 133 GTP 132 SCH 132 LPS 132 cyclooxygenase-2 130 PARK6 129 ANOVA 128 She 126 GDNF 126 5-hydroxytryptamine 125 glutamate receptor 125 lactate dehydrogenase 124 c-Jun 123 erythroid 123 asymmetrical 121 proteasome inhibitor 119 caspase-9 119 neuronal protein 118 NAD 117 GSK 117 ALS 115 neurotrophin 112 fused 111 MSA 111 SDS 110 CA1 110 amyloid beta 109 interleukin-6 107 phosphatase 107 extracellular signal-regulated kinase 106 GBA1 106 choline acetyltransferase 105 cytochrome 105 polypeptide 105 PGC 104 NADH 104 threonine 102 alpha synuclein 101 D2 dopamine receptor 101 membrane-bound 99 metabotropic glutamate receptor 99 adenosine receptor 98 synphilin-1 98 transferrin 97 calbindin 96 outer mitochondrial membrane 95 DA transporter 95 antioxidant enzyme 94 PARK8 94 COX-2 92 TDP-43 92 SOD1 91 apolipoprotein E 91 dopamine D1 receptor 90 calpain 90 somatostatin 90 p65 89 beta-synuclein 89 catenin 88 prolactin 88 FDG 88 HSP70 87 more...

Disease Parkinson's disease 63064 Alzheimer's disease 9103 parkinsonism 5149 dementia 4717 depression 3187 Huntington's disease 2328 amyotrophic lateral sclerosis 2096 cognitive impairment 1970 dyskinesia 1930 stroke 1716 multiple sclerosis 1570 movement disorder 1501 schizophrenia 1490 progressive supranuclear palsy 1035 cancer 1030 epilepsy 985 diabetes 869 neuroblastoma 867 Dementia with Lewy bodies 848 psychosis 836 akinesia 830 hallucinations 751 neurological disease 560 GSH 441 sleep disorders 438 ischemia 347 abnormal involuntary movements 338 hypertension 337 tumor 316 sleep disturbances 307 dysphagia 302 major depressive disorder 299 PARK2 295 autism 290 addiction 282 catalepsy 255 restless legs syndrome 249 REM sleep behavior disorder 246 Gaucher disease 239 behavior disorder 230 cerebral ischemia 220 type 2 diabetes 218 obesity 213 Tourette syndrome 213 delusions 207 obsessive-compulsive disorder 200 CNS diseases 194 drug addiction 181 memory impairment 177 PARK7 174 HIV 172 cardiovascular disease 165 migraine 163 bipolar disorder 163 myelodysplastic syndrome 159 MDS 156 confusion 156 atherosclerosis 155 chronic pain 155 impulse control disorder 150 Creutzfeldt-Jakob disease 146 Down syndrome 146 pathological gambling 144 rheumatoid arthritis 143 brain atrophy 142 tardive dyskinesia 141 motor neuron disease 140 mental illness 138 plaque 138 Multiple system atrophy 138 incontinence 134 SCH 132 encephalopathy 131 pheochromocytoma 130 ADHD 126 osteoporosis 124 apraxia 120 anxiety disorders 120 PDD 120 glaucoma 119 dysautonomia 118 melanoma 116 neuropathy 116 MSA 111 SDS 110 disinhibition 105 hypersexuality 104 cognitive deficit 104 Friedreich's ataxia 104 malnutrition 101 heart failure 100 Essential tremor 99 cerebral palsy 98 degenerative disease 98 vascular disease 98 hydrocephalus 97 delirium 97 narcolepsy 96 Pick's disease 95 myocardial infarction 93 fits 91 senile dementia 91 drug abuse 90 cold 88 PARK6 87 breast cancer 86 Wilson's disease 85 encephalitis 85 camptocormia 85 peripheral neuropathy 84 asthma 82 amyloidosis 82 pneumonia 82 hemiparkinsonism 81 chronic disease 80 anhedonia 79 aphasia 79 worms 78 PARK8 77 mania 75 alcoholism 74 anemia 74 Syndrome 74 arthritis 74 influenza 73 muscular atrophy 72 osteoarthritis 71 inflammatory bowel disease 71 immunodeficiency 71 Dystonia 70 glioma 70 AIDS 70 PAF 70 PSP 68 affective disorder 68 macular degeneration 67 polyneuropathy 66 aspiration pneumonia 66 Crohn's disease 65 mental retardation 65 substance abuse 64 tumorigenesis 64 induced psychosis 63 SEM 62 suicide 62 heart disease 62 mental retardation 62 sleep apnea 61 infectious diseases 61 nocturia 58 myocardial ischemia 58 West 57 posttraumatic stress disorder 56 incontinence 56 hyperhomocysteinemia 56 myopathy 56 herpes simplex 54 sexual dysfunction 54 iron overload 54 olivopontocerebellar atrophy 54 more...

Symptom tremor 3558 bradykinesia 1684 dystonia 1074 pain 890 sleepiness 458 apathy 389 fatigue 386 motor symptom 360 constipation 341 ataxia 277 seizures 273 insomnia 223 functional recovery 209 dysarthria 201 anesthesia 193 nausea 192 muscle rigidity 166 weakness 153 chorea 148 abnormal gait 137 headache 116 myoclonus 113 agitation 103 dizziness 98 cerebellar ataxia 96 discomfort 95 discomfort 92 vomiting 90 spasticity 85 thinning 80 visual hallucination 79 collapse 77 memory loss 66 syncope 63 anosmia 60 drooling 60 diarrhea 53 Involuntary Movement 51 nausea and vomiting 50 cough 50 blepharospasm 49 stigma 48 starvation 48 eds 47 anorexia 46 dyspnea 46 analgesia 44 Rest tremor 39 Depressive symptoms 37 catatonia 36 Parkinsonian tremor 33 abdominal pain 32 hypertonia 31 back pain 29 hypersomnia 29 tinnitus 29 intention tremor 29 muscle stiffness 26 paresis 26 paresthesia 25 hypothermia 25 ophthalmoplegia 25 torticollis 24 regurgitation 23 spasm 23 distraction 23 vertigo 22 stridor 22 incoordination 22 low back pain 22 respiratory distress 21 Decreased activity 20 asthenia 20 exhaustion 20 hemiplegia 19 lightheadedness 19 forgetfulness 17 athetosis 17 pallor 16 overweight 16 chronic constipation 15 loss of balance 15 dysuria 15 hypercapnia 15 dry eye 14 alexithymia 14 chest pain 14 despair 13 Extrapyramidal symptoms 13 Psychiatric symptoms 13 angina 13 Postural tremor 13 Motor dysfunction 12 lethargy 12 muscle cramps 12 Stepping 12 excessive sweating 11 numbness 11 tense 11 hoarseness 11 Fluctuation 11 livedo 10 mental fatigue 10 acidity 10 impaired motor coordination 10 twitching 10 hypotonia 10 acute stress 9 bloating 9 neurological disability 9 snoring 9 ataxic gait 9 tingling 9 personality change 8 neuralgia 8 Gastrointestinal symptoms 8 disturbed balance 8 urinary frequency 8 leg edema 8 heartburn 8 ENT 8 Sedation 7 flushing 7 blurred vision 7 shortness of breath 7 clumsiness 7 Urinary symptoms 6 Fear of falling 6 facial pain 6 hopelessness 6 skin irritation 6 arthralgia 6 Fear of falling 6 Behavioral symptoms 6 Ill 6 neck pain 6 Swallowing problems 6 abdominal discomfort 6 paraparesis 6 leg pain 6 enuresis 6 consciousness disturbance 6 limb pain 5 Parkinsonian rest tremor 5 asterixis 5 clonus 5 Lower urinary tract symptoms 5 cachexia 5 hyperoxia 5 bitter taste 5 myalgia 5 auditory hallucination 5 hepatosplenomegaly 5 splenomegaly 5 hunger 5 loss of taste 5 dysosmia 5 adipsia 5 Primary orthostatic tremor 4 Multimorbidity 4 more...

Drug Parkin 914 Parkin 914 DBS 378 ROS 285 CSF 259 caffeine 224 Apomorphine 201 Sinemet 174 MDS 155 Sinemet 141 Posture 131 lysine 130 vitamin E 129 Sinemet 127 Pramipexole 122 Pramipexole 113 NADH 106 Rasagiline 105 ascorbate 98 Spectrum 98 Frontal 97 ROC 93 Rotigotine 68 Glutathione 67 Madopar 63 BH4 56 CFT 49 Monit 49 Carbidopa 48 Dermatol 40 Zonisamide 36 L-tyrosine 31 3,4-Dihydroxyphenylalanine 30 Lisuride 29 Heme 28 Reserpine 27 IL-2 27 MAP 27 ENT 26 Leaf 26 Eldepryl 26 Nephron 26 Histamine 26 niacin 25 p75 25 HCH 23 Istradefylline 21 Azilect 21 Eldepryl 21 Tocopherol 20 TMS 20 Cardiovasc 19 ABC 19 IPD 18 PCP 17 Modafinil 16 Glucagon 16 Vitamin E 15 IFN-gamma 15 Domperidone 15 Simvastatin 15 nitroglycerin 15 citric acid 14 Spectrum 14 Droxidopa 14 ICI 13 Angiotensin II 12 EE2 12 Benserazide 12 Donepezil 12 Gel 12 Parlodel 11 Clonidine 11 Asn 11 Ginseng 11 lactose 10 Bifidobacterium 10 Parlodel 10 Ethanol 10 Indomethacin 10 TAT 9 Award 9 Terguride 9 RFP 9 Estrogens 9 Mirapex 9 Android 8 Exenatide 8 Retinoic acid 8 Nitric Oxide 8 ALA 8 Zydis 8 Kainic acid 7 Portal 7 7-Nitroindazole 7 Botox 7 Requip 7 pyridoxal phosphate 7 Fragment 6 Methylene blue 6 GEO 6 Alliance 6 Glycyrrhiza 6 BoNT/A 6 Doxycycline 6 Glutamic acid 6 EPA 6 Comtan 6 CTX 6 Vitamin A 6 Camp 6 Diurnal 6 Mazindol 6 Rosiglitazone 6 Glycerol 6 Cisapride 6 Scopolamine 6 Moclobemide 5 Rutin 5 Lazabemide 5 Biopolymers 5 Midodrine 5 Requip 5 Permax 5 FeCl3 5 FAD 5 Sulpiride 5 Epigallocatechin 5 Adenosine triphosphate 5 Copaxone 5 Permax 5 CVA 5 G-CSF 5 Vitamin B12 4 balanced salt solution 4 IL-1ra 4 Taxol 4 Diphenhydramine 4 CTX 4 Lergotrile 4 Arsenic trioxide 4 TiO2 4 Artane 4 Ginger 4 Tacrolimus 4 ACT 4 9-THC 4 TTC 4 Myricetin 4 Tianma 4 TAK 4 Riboflavin 4 CFS 4 Atomoxetine 4 Idebenone 4 ETS 4 Fluorescein 4 Itraconazole 4 ADM 4 Desferal 4 more...

Enzyme tyrosine hydroxylase 2796 MPP 846 proteasome 831 complex I 817 monoamine oxidase 785 mitogen-activated protein kinase 725 superoxide dismutase 599 caspase-3 586 protein kinase 507 catalase 362 acetylcholinesterase 352 ACS 326 glucocerebrosidase 311 ERK 292 glutathione peroxidase 204 cholinesterase 191 DAT 161 ATPase 156 focal adhesion kinase 139 luciferase 136 lactate dehydrogenase 130 GSK 128 NADPH oxidase 120 NADPH oxidase 116 protein kinase C 113 PARP 108 DOPA decarboxylase 108 choline acetyltransferase 105 AMP-activated protein kinase 105 cytochrome oxidase 100 MEK 99 peroxidase 98 calcineurin 90 caspase-9 90 NO synthase 86 succinate dehydrogenase 77 aromatic L-amino acid decarboxylase 76 NQO1 76 tyrosinase 72 glutathione S-transferase 69 AMPK 68 ceruloplasmin 67 renin 66 glutathione reductase 63 phosphatidylinositol 3-kinase 63 proteinase K 59 diaphorase 55 AMPK 54 phosphodiesterase 53 phospholipase A2 50 caspase-1 49 creatine kinase 49 GTP cyclohydrolase I 48 ACE 47 NOS 46 ubiquitin-protein ligase 46 aldehyde dehydrogenase 46 Thy1 45 Omi/HtrA2 45 aldehyde dehydrogenase 45 aldehyde dehydrogenase 43 aldehyde dehydrogenase 43 aldehyde dehydrogenase 43 cathepsin D 41 isopeptidase 40 glyceraldehyde-3-phosphate dehydrogenase 40 phosphoinositide 3-kinase 40 P-glycoprotein 39 catechol O-methyltransferase 39 adenylate cyclase 38 NADH dehydrogenase 37 protein phosphatase 2A 36 ATP synthase 36 trypsin 34 heme oxygenase 34 beta-galactosidase 32 glyceraldehyde-3-phosphate dehydrogenase 32 caspase-8 32 reverse transcriptase 32 CEP 31 transglutaminase 31 glyceraldehyde-3-phosphate dehydrogenase 31 IKK 30 CEP 30 glyceraldehyde-3-phosphate dehydrogenase 29 glyceraldehyde-3-phosphate dehydrogenase 29 peroxiredoxin 28 lysozyme 28 gamma-glutamylcysteine synthetase 27 alpha-ketoglutarate dehydrogenase 27 botulinum neurotoxin 25 tryptophan hydroxylase 25 aconitase 24 phospholipase C 23 dopamine beta-hydroxylase 23 thrombin 23 cathepsin B 22 MEKK1 22 glutamate decarboxylase 22 gamma-glutamyl transpeptidase 21 GRK5 21 NADPH-diaphorase 20 alcohol dehydrogenase 20 RNase 20 CaMKII 20 xanthine oxidase 20 enolase 20 cdc2 19 kinesin 19 citrate synthase 19 CD10 18 MMP 18 TMT 18 RNase 18 cyclohydrolase 17 paraoxonase 17 MAP 17 PCP 17 glutamate dehydrogenase 16 glutamate dehydrogenase 16 glutamate dehydrogenase 16 alkaline phosphatase 16 pyruvate dehydrogenase 16 methylenetetrahydrofolate reductase 15 endonuclease 15 paraoxonase 15 methylenetetrahydrofolate reductase 15 aspartate aminotransferase 15 pantothenate kinase 14 alanine aminotransferase 14 diaphorase 14 isocitrate dehydrogenase 14 RNA polymerase 13 guanylate cyclase 13 DNA polymerase 13 pyruvate dehydrogenase 12 arginase 12 pyruvate dehydrogenase 12 triphosphatase 12 polo-like kinase 1 12 glutamine synthetase 12 CPR 12 histone acetyltransferase 12 neurosin 11 kynurenine 3-monooxygenase 11 aldose reductase 11 STR 11 prolyl endopeptidase 11 CPT 10 prolyl hydroxylase 10 firefly luciferase 10 GRK2 10 hexosaminidase 10 collagenase 10 DCF 10 diamine oxidase 10 chaperonin 10 chymotrypsin 9 CPT 9 CAD 9 more...

Compound Dec 3840 MPTP 3217 L-DOPA 2869 Clin 2682 oxygen 2275 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 2040 DNA 1551 iron 1322 glutamate 1276 Dopamine 1058 calcium 1022 MPP 843 MPP 843 water 702 ATP 702 nitric oxide 641 glucose 538 tyrosine 520 hydrogen 509 GSH 486 GSH 486 GABA 478 GABA 475 manganese 454 5-HT 418 cysteine 390 DBS 378 TNF 363 copper 357 noradrenaline 349 sodium 337 ACS 326 ACS 326 Neuronal 326 leucine 298 NMDA 298 serine 297 Dopa 281 CIT 278 CIT 274 PDQ 237 zinc 235 Rotenone 233 caffeine 232 potassium 225 nitrogen 212 MTT 204 phosphate 204 cAMP 204 alanine 193 H2O2 187 methionine 186 His 184 lysine 183 threonine 179 homocysteine 162 DAT 161 Selegiline 159 DOPAC 157 tryptophan 153 arginine 152 N-acetylcysteine 146 tryptophan 146 NAD 145 sulfate 144 tryptophan 140 tryptophan 140 nicotinamide 134 3,4-dihydroxyphenylalanine 134 gamma-aminobutyric acid 134 Adenosine 133 GTP 133 DSM 132 Cereb 132 pyridine 131 Glutamate 127 AMPA 121 iodine 117 NAD 117 Paraquat 114 Paraquat 114 4-phenyl-1,2,3,6-tetrahydropyridine 113 SDS 112 Phe 112 acetate 109 NADH 105 Amantadine 102 glutamine 102 vitamin D 101 bromide 101 Amantadine 100 galactose 100 Amantadine 100 6-Hydroxydopamine 99 Amantadine 98 coenzyme Q10 97 aldehyde 97 HVA 95 Off 94 ethanol 92 Nicotine 88 silver 86 Bromocriptine 86 aldehyde 86 Melatonin 84 Leucine 83 1,2,3,4-tetrahydroisoquinoline 83 retinoic acid 79 salt 79 Clozapine 78 NADPH 73 NADPH 73 AMP 71 CO2 70 Pergolide 70 1,2,3,6-tetrahydropyridine 69 1,2,3,6-tetrahydropyridine 69 Curcumin 69 Ropinirole 68 PSP 68 aluminum 65 ADP 64 fluorine 63 proline 63 ubiquinone 63 cyanide 62 Methamphetamine 61 4-phenylpyridine 61 Panam 61 Entacapone 61 PEG 61 Tolcapone 60 pyrimidine 60 GM1 60 pyrimidine 60 ADP 59 ADP 59 acetic acid 58 GSSG 57 Ubiquitin 57 hydroxyindoleacetic acid 56 MEK 55 Cu(II) 55 MDA 54 ammonium 54 Asp 54 isoquinoline 52 urea 51 cGMP 50 H2S 50 adenosylmethionine 49 Cabergoline 49 ACh 48 selenium 46 1-Methyl-4-phenylpyridinium 46 NH2 44 2-nonenal 44 TOF 43 HCl 43 N-acetylaspartate 43 more...

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