Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030567 (
Parkinson's disease
)
63,064
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The newly discovered
Cbl-interacting protein of 85 kDa
(
CIN85
) is involved in many cellular processes, but its functions in the brain and in neurodegenerative diseases remain unclear. In this paper, we investigated the distribution of
CIN85
protein in different regions of adult mouse brain using Western blot analysis and immunohistochemistry, and found that
CIN85
was ubiquitously expressed in mouse brain. In the striatum and substantia nigra, two regions most deeply affected in
Parkinson's disease
, the level of
CIN85
protein was relatively high. In the MPTP mouse model of
Parkinson's disease
, the expression of
CIN85
in the striatum and substantia nigra was complicated. But in 1-methyl-4-phenyl-pyridinium ion-treated human dopaminergic SH-SY5Y cells, the expression of
CIN85
increased dramatically. Knocking down of
CIN85
by short hairpin RNA reduced SH-SY5Y cell death. Therefore,
CIN85
might play different roles in the dopaminergic cell line and in the nigrostriatum of mouse brain under neurotoxin challenge.
...
PMID:Expression of Cbl-interacting protein of 85 kDa in MPTP mouse model of Parkinson's disease and 1-methyl-4-phenyl-pyridinium ion-treated dopaminergic SH-SY5Y cells. 1853 49
