Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Vascular parkinsonism has not been well defined and the clinical correlation of vascular parkinsonism is still not clear. The aim of the study was to estimate prevalence of occurrence of vascular parkinsonism, analysis of risk factors leading to its development and to identify clinical features that suggest a vascular origin. 214 patients with Parkinson's disease were examined. Their ages ranged from 37 to 88 years (median 66.4 years). Evidence of vascular parkinsonism was assessed using a vascular rating scale previously described by Winikates and Jankovic. Statistical analysis was performed with Mann-Whitney U test, chi 2 Pearson test, chi 2 Yates test, Spearman rank correlation and Student's t test. Out of 214 patients 8 were proved to have developed Parkinson's disease due to vascular disease, what gave 3.74%. Out of risk factors for stroke 5 patients had hypertension, 3 had diabetes mellitus, 2 suffered from heart disease, 2 had infarctus myocardii, 1 had hyperlipidemia, 1 had atrial fibrillation. Additionally, those patients had neuroimaging (CT or MRI) evidence of vascular disease in one or more vascular territories. Patients with vascular parkinsonism were older, had shorter duration of disease, were more likely to present rigidity rather than tremor. Dementia and incontinence were more common in vascular group than in Parkinson's disease group. Patients with vascular parkinsonism were also significantly more likely to have corticospinal findings. Proving that Parkinson's disease had vascular etiology is extremely difficult. The test results are inconclusive.
Neurol Neurochir Pol 2003
PMID:[Clinical correlation of vascular parkinsonism]. 1509 42

The aim of the study was to evaluate the frequency of depression in patients with Parkinson's disease. The authors recruited 85 patients with idiopathic Parkinson's disease, 42 males and 43 females aged 34-82 years (mean age 68.7). Age at onset ranged 24-79 (mean 60.9 years). Disease duration ranged from 3 month to 20 years (mean 7.86 years). In 62 patients (72.94%) mixed type of the disease was diagnosed, in 14 (16.47%) tremor and in 9 (10.59%) rigidity predominated. UPDRS was used to evaluate the severity of the disease (results ranged 28-90, mean 51.4). Activity of daily living was estimated according to Schwab and England Scale (range 40-90, mean 68.1). Depression was evaluated with Hamilton, Beck and Montgomery-Asberg scales. The results were analysed with Spearman correlation. Depression was diagnosed in 53 (62.35%) patients [in 7 (8.24%) light; in 14 (16.47%) middle; in 19 (22.35%) heavy; in 13 (15.29%) very heavy]. The results acquired with all three scales were not statistically different. There were significant positive correlations between depression and female sex, severity of the disease, dyskinesia as side effect of.
Neurol Neurochir Pol 2003
PMID:[Depression in Parkinson disease: own experience]. 1509 43

The aim of the reports is to emphasize difficulty in treatment of Parkinson's disease in patients with surgical problems. Complex treatment of this patients is of major therapeutic challenge. The use of either soluble forms of levodopa, parenteral amantadine or apomorphine in the immediate postoperative period for patients unable to take oral antiparkinson drugs and early resumption of the oral antiparkinson drugs increases patients' comfort, may reduce serious postoperative complications and are the key points in the management of the patients.
Neurol Neurochir Pol 2003
PMID:[Treatment of Parkinson disease in patients with surgical problems]. 1509 45

We are presenting a case of Parkinson-ALS-Dementia complex in 53 years old male. Outstanding bulbar signs with muscular atrophy of tongue, muscular atrophy of shoulder girdle together with massive fasciculations (myoclonus type descending from spinal cord) have been observed. Clear Parkinson's syndrome coexisted--bradykinesia, rigidity with cogwheel resistance, "masking" of the face, disturbances of body balance and significant vegetative signs. Moreover psychological testing has shown psycho-organic syndrome of frontal type, MRI scans proved the existence of slight brain general atrophy that is most prominent in frontal et temporal poles. Diseases of this kind occur all over the world sporadically. The case of ALS--dementia complex was observed in our clinic a year ago.
Neurol Neurochir Pol 2003
PMID:[Parkinsonism-ALS-dementia complex: case report]. 1509 46

The treatment of patients with Parkinson disease should consist of early, complex and continuous rehabilitation connected with reasonable drug therapy. Rehabilitation carried out in hospital, rehabilitation center, sanatorium and outpatient rehabilitation clinic enables better education of patients and their families. Patients' self-consciousness of necessity of continuous daily physical activity at home has a great influence on the length and quality of their life. Physical activity is the best way of prevention of disability and secondary complications caused by immobilization in movement and other systems. It improves also patients' protective forces. Rehabilitation, on the contrary to drug therapy, is cheep, has no adverse effects and can be carried out at home. I this paper are presented the following principles of complex rehabilitation: patients' self-education of Parkinson disease, the proper way of life and work as well as the most effective ways of physiotherapy, occupational therapy and art therapy.
Neurol Neurochir Pol 2003
PMID:[Rehabilitation of patients with Parkinson disease]. 1509 49

There is little information on the efficacy of various surgical interventions in terms of health-related quality of life in Parkinson's disease (PD) patients. Most studies evaluated only motor symptoms of PD after surgical treatment avoiding subjective patient's assessment. The goal of this study is the assessment of surgical treatment of PD on quality of life using Parkinson's Disease Questionnaire (PDQ-39). To 134 patients PDQ-39 questionnaires were send, 91 of them responded. Among 91 patients 32 underwent unilateral thalamotomy, 38 unilateral pallidotomy and 21 bilateral staged pallidotomy. The patients were assessed at baseline and 3 to 6 months after surgery. The PDQ-39 recorded significant improvement in mobility, activity of daily living and stigma in thalamotomy and pallidotomy group. The most striking improvement was noticed in bilateral pallidotomy group. After bilateral pallidotomy improvement was noticed in mobility, ADL, emotional well being, stigma and bodily discomfort. Our results indicate that quality of life in PD patients after surgical treatment is measurable according to PDQ-39 and the most benefit is noted in patients who underwent bilateral staged pallidotomy.
Neurol Neurochir Pol 2003
PMID:[Evaluation of quality of life in Parkinson disease treatment]. 1509 50

In this review report current possibilities of evaluation of quality of life in Parkinson's disease has been critically presented. Health Related Quality of Life (-HRQoL) comprise wide spectrum of consequences of disease. Measurement of quality of life has become increasingly relevant as an outcome parameter, especially in long-term trials. Most of the available QoL instruments depend on patient self-reports. The data can be collected by written questionnaires. There are universal questionnaires of QoL--for many diseases and the specific ones--specially created for one disease. Among universal questionnaires the Sickness Impact Profile (SIP) and the Short-Form Health Status Survey (SF-36) are most popular in Parkinson's disease. As for specific questionnaires: the Parkinson's Disease Questionnaire (PDQ-39) (by Peto and Jenkinson, 1995) and the Parkinson's Disease Quality of Life Questionnaire (PDQL) (by de Boer and al., 1996) has been described.
Neurol Neurochir Pol 2003
PMID:[Current possibilities of evaluation of quality of life in Parkinson disease]. 1509 52

Differential diagnosis of idiopathic Parkinson's Disease is still very difficult. Even in movement disorders centers 25% of patients with clinical diagnosis of Parkinson's disease is misdiagnosed with other neurodegenerative disorders. Clinical symptoms of so called atypical parkinsonian disorders may emerge late in the course of the disease, not at the same time and good or moderate response to levodopa at early stages may be a source of misdiagnosis. Most difficult to differentiate seems to be Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and multiple system atrophy (MSA). Authors present in selected cases usefulness of neuroimaging with rCBF SPECT and MRI in clinical diagnosis of these disorders. For PSP typical (although not pathognomonic) is decrease of metabolism and flow in frontal lobes (hypofrontalism), and in CBD asymmetrical, contralateral to the side of dominating symptoms cerebral (frontal, parietal, temporal and within striatum) atrophy. In MSA more useful (but not seen in all cases) is MRI examination with hyperintensities in putamen, pons and cerebellum or cerebellar atrophy. Due to low sensitivity of clinical criteria other tests (EMG of anal sphincter or clonidine test) with specially neuroimaging examination may be helpful in establishing of the diagnosis.
Neurol Neurochir Pol 2003
PMID:[Regional cerebral blood flow single photon emission tomography (SPECT) and magnetic resonance imaging (MRI) may be useful in the diagnosis of patients with cortico-basal degeneration, progressive supranuclear palsy and multiple system atrophy]. 1509 54

Many patients with Parkinson's disease (PD) suffer from severe bilateral appendicular off (bradykinesia, rigidity, tremor) and on (dyskinesia, dystonia) symptoms. After unilateral pallidotomy several of these patients still suffer from severe bradykinesia, rigidity, or dyskinesia of the ipsilateral side. In addition such symptoms as walking difficulty, freezing, trunk, neck, or facial dyskinesia are not significantly alleviated after unilateral pallidotomy. These patients seem to be good candidates for bilateral staged pallidotomy. The aim of this study is to evaluate the motor symptoms after staged bilateral pallidotomy in advanced PD patients. 34 patients were studied. The patients were assessed using UPDRS version 3, Hoehn and Yahr scale, Schwab and England scale before and up to 24 months after surgery in off and on state. In off drug state, the total motor score of the UPDRS compared to preoperative off drug state was improved by 61% at 24 months of follow-up. All cardinal features of PD improved significantly in postoperative drug off state compared to drug off state before bilateral pallidotomy--parkinsonian tremor (items 20-21) by 62%, rigidity (item 22 UPDRS) by 81% and bradykinesia (items 23-26) by 67%. Also gait including falling, freezing, walking (items 13-14-15 UPDRS) and gait and postural stability (items 29-30 UPDRS) showed good improvement by 69% with bilateral pallidotomy in off drug phases. There was minimal improvement in motor score of UPDRS in on state. Duration of dyskinesia and severity of dyskinesia (items 32-33 UPDRS) showed dramatic improvement after bilateral pallidotomy. Bilateral pallidotomy affords impressive elimination of all appendicular and truncal dyskinesias, dystonias, and generally improved all symptoms in off state.
Neurol Neurochir Pol 2003
PMID:[Bilateral pallidotomy for the treatment of advanced Parkinson disease]. 1509 53

Pathogenesis of many diseases is related to the influence of noxious environmental agents coupled with individual genetic sensitivity that depends on the function of detoxificating enzymes. One of the latter is N-acetyltransferase 2 whose mutations lead to an impairment of the enzyme function. Genetically determined acetylation rate reduction with exposure to neurotoxins may contribute to the development of Parkinson's disease (PD). While both genetic and environmental factors are implicated in etiology of PD, genetic factors may play a crucial role in early-onset Parkinson's disease (in patients aged under 50).
Neurol Neurochir Pol
PMID:[The role of N-acetyltransferase polymorphism in the pathogenesis of Parkinson's disease]. 1517 55


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