Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030567 (
Parkinson's disease
)
63,064
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
An insertional (460-461InsA) mutation in the
ferritin light polypeptide
(
FTL
) gene was recently reported in some patients with a familial form of basal ganglia degeneration with varying extrapyramidal manifestations. Some of the affected family members presented with a phenotype indistinguishable from typical
Parkinson's disease
(PD). In this study, 253 patients with a clinical diagnosis of idiopathic PD were screened for the insertion in the
FTL
gene by polymerase chain reaction-restriction fragment length polymorphism method. The results showed that none of them had the mutation, indicating that genetic defects in the
FTL
gene are unlikely to be a common cause of typical PD, at least in a North America population.
...
PMID:Screening of ferritin light polypeptide 460-461InsA mutation in Parkinson's disease patients in North America. 1245 18
