Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Degenerative processes in the corpus striatum, neuroleptics drugs, thyroid disease, and Parkinson's disease are all causes of abnormal spontaneous movements in the elderly. Differential diagnosis is essential for selecting the proper therapy, and the patient's history often provides the key.
Geriatrics 1979 Sep
PMID:Involuntary movement disorders--each has a meaning all its own. 3 89

23.3 per cent out of 180 old patients (age above 60 years, 71 y in the mean) suffering from chronic cerebral disorders (3 large groups of disease) developed pharmacotoxic psychoses. This relative high percentage can be explained by psychotoxic side effects of the modern antiparkinson-therapy. The incidence to psychotoxicity of combined L-Dopa seems to be less marked in patients without Parkinson's disease when compared to patients with progredient nigrostriatal degeneration. Toxic delirium as a result of treatment with antidepressants, diuretics and digitalis was observable only in a few percentage. This occurance was even less pronounced in comparison to acute developing exogene psychoses in the same group of patients when drugs were not administered.
Aktuelle Gerontol 1979 Sep
PMID:[Pharmacotoxic psychoses in patients with neurological disorders during old age (author's transl)]. 4 22

In order to investigate the influence of basal ganglia and cerebellar involvement on the preparatory state of the cerebral cortex for voluntary movement, the cortical potential preceding finger movement was studied in 20 patients with Parkinson's disease and 20 patients with cerebellar ataxia. Readiness potential (RP) was abnormal in 90% of the Parkinson group and in 55% of the cerebellar ataxia group. The most frequent abnormality was a depressed amplitude and earlier onset of RP in both groups. The most remarkable finding in the present study was the complete absence of RP with dyssynergia cerebellaris myoclonica (presumed Ramsay Hunt syndrome) whereas normal RP was obtained with cerebellar cortical degeneration. In addition, RP was absent or severely depressed in patients with a unilateral vascular lesion of the midbrain (Benedikt's syndrome) and in patients with Parkinson's disease who underwent unilateral intermedioventral (Vim) thalamotomy. These facts suggest a possible important role of the dentatorubrothalamic or dentatothalamic pathway in the physiogenesis of RP.
J Neurol 1978 Sep 12
PMID:Clinical studies of the movement-related cortical potential (MP) and the relationship between the dentatorubrothalamic pathway and readiness potential (RP). 8 Dec 81

The habituation index is a quantitative expression of the ability of the orbicularis oculi (blink reflex) to adapt to a series of electrical stimuli applied to the supraorbital region. This parameter has been studied in a group of normal control subjects, and the results compared with those in cases of idiopathic and drug-induced Parkinsonism, states of dementia, and dyskinesias such as Huntington's chorea and senile chorea. Patients with Huntington's chorea showed a tendency for the reflex to habituate readily in contrast to patients with dementia caused by cortical atrophy and those with Parkinson's disease. Younger patients with Huntington's chorea had indices within the normal range. It seems unlikely that this test will prove of value in the detection of clinically unaffected relatives. Where dementia was associated with a reversible intracranial lesion, the habituation index was studied before and after treatment. Failure of habituation in this condition appears to be due to the release of a primitive protective reflex.
J Neurol Neurosurg Psychiatry 1978 Sep
PMID:Habituation of the orbicularis oculi reflex in dementia and dyskinetic states. 15 Nov 27

The characteristic oily skin in individuals with parkinsonism has long been observed by clinicians. The oiliness seems to be associated with periods when the disease is most active. This seborrhea has been observed particularly in post-encephalitic parkinsonism, as well as in idiopathic paralysis agitans. It also occurs in phenothiazine-induced parkinsonism.
Prim Care 1977 Sep
PMID:The skin in Parkinson's disease. 16 45

The diagnosis of Parkinson's disease is mostly likely to be made when it is kept in mind, when it is thought of in a broad context, when patients are seen while moving, and when the tests for the three disorders of movement are systematically performed.
Prim Care 1977 Sep
PMID:Parkinson's disease as a disorder of movement. 26 19

Paralysis agitans may be mimicked by other disease processes and drugs which disturb the structural or functional integrity of the dopaminergic nigrostriatal system. In another group of patients, isolated symptoms or signs such as tremor or increased muscle tone are considered out of the context of the total clinical picture and may suggest parkinsonism.
Prim Care 1977 Sep
PMID:Differential diagnosis of paralysis agitans. 26 20

Involvement of the urinary bladder in Parkinson's disease was recognized in the 1950's, when the accidental discovery of a neurosurgical means of treating the disease brought more attention to it, with increasing research and study. In more recent years, the advent of more specific medical treatment has led to closer examination of the disease, and has enlarged our awareness of its complications. This has been paralleled by progress in the field of urology, with more precise methods of measuring dysfunction of the urinary bladder.
Prim Care 1977 Sep
PMID:Neurogenic dysfunction of the urinary bladder in Parkinson's disease. 26 23

This article is written in order to help the patient with Parkinson's disease function as independently as possible. It is not meant to be a complete treatment program, but a collection of helpful ideas based on the experience of physiotherapists who work with these patients daily, and on information acquired from such patients. The techniques are applicable at home and in the hospital.
Prim Care 1977 Sep
PMID:Home care of patients with Parkinson's disease. 26 25

Methods and aids for helping the individual with Parkinson's disease overcome some of the problems encountered in daily living. Only by a continuous, on-going program, much patience, and knowledge of how and what can be done can the patient be helped to maintain his interests and independence within the range of his abilities.
Prim Care 1977 Sep
PMID:Self-care aids for the parkinsonian patient and his family. 26 26


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