Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adenosine deaminase (ADA) is a deaminating enzyme consisting of isozymes ADA 1 and ADA 2. We measured the activities of total ADA, ADA 1 and ADA 2 in serum obtained from 42 patients with Parkinson's disease (PD). Patients were divided into 10 cases of stage I, 20 of II, 11 of III and 1 of IV according to the clinical stages described by Hoehn and Yahr. The total and ADA 2 activities were significantly higher in patients as compared with normal controls (p < 0.01, respectively). However, this study did not detect any tendency for elevated total ADA or its isozyme activities with advance in clinical stages described by Hoehn and Yahr. ADA and ADA 2 are thought to have important roles in the regulation of the immune function. On the other hand, recent reports have suggested that immunological abnormality may be responsible for the developing of PD. Our results also suggest that high serum ADA activity may be involved in the pathogenesis of PD through the alteration of the immune function.
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PMID:[Serum adenosine deaminase and its isozyme activities in patients with Parkinson's disease]. 833 83

Adenosine deaminase (ADA) and its isozyme activities in serum were measured together with peripheral lymphocyte subsets in 42 patients with idiopathic Parkinson's disease. The total and ADA 2 activities were significantly higher than normal controls (p < 0.01). As regards the peripheral lymphocyte subsets, the proportion of OKT 10+ cells (activated T lymphocytes) and the proportions of interleukin-2 receptor+ and HLA-DR+ cells (mainly activated T lymphocytes) were significantly higher than normal controls (p < 0.05, 0.01, 0.01, respectively). On the other hand, OKT 10+ cells demonstrated a significant correlation not only with total ADA but also with ADA 2 activity. These results suggest that high serum ADA activity may be involved in the pathogenesis of Parkinson's disease through peripheral T lymphocyte activation.
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PMID:A correlation study between serum adenosine deaminase activities and peripheral lymphocyte subsets in Parkinson's disease. 854 43