Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030567 (
Parkinson's disease
)
63,064
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The objective is to search potential therapeutic drugs for
Parkinson's disease
based on data mining and bioinformatics analysis and providing new ideas for research studies on "new application of conventional drugs." Method differential gene candidates were obtained based on data mining of genes of PD brain tissue, original gene data analysis, differential gene crossover, pathway enrichment analysis, and protein interaction, and potential therapeutic drugs for
Parkinson's disease
were obtained through drug-gene relationship.
Result
. 250 common differential genes were obtained from 3 research studies, and 31 differential gene candidates were obtained through gene enrichment analysis and protein interaction. 10 drugs such as
metformin hydrochloride
were directly or indirectly correlated to differential gene candidates.
Conclusion
. Potential therapeutic drugs that may be used for prevention and treatment of
Parkinson's disease
were discovered through data mining and bioinformatics analysis, which provided new ideas for research and development of drugs. Results showed that
metformin hydrochloride
and other drugs had certain therapeutical effect on
Parkinson's disease
, and melbine (DMBG) can be used for treatment of
Parkinson's disease
and type 2 diabetes patients.
...
PMID:Potential Therapeutic Drugs for Parkinson's Disease Based on Data Mining and Bioinformatics Analysis. 3037 44
