Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We analyzed the clinical and physiological features of autonomic failure with Parkinson's disease (AF-PD) in seven patients and compared them with those of autonomic failure with multiple system atrophy (AF-MSA). In AF-PD, parkinsonism was more gradually progressive than in AF-MSA, and symptoms were responsive to L-dopa. All seven patients with AF-PD had orthostatic hypotension, postprandial hypotension, and constipation, but no urinary retention. Of these, three had hypohidrosis and five had frequent urination; five patients had subnormal plasma norepinephrine (NE) concentrations. Supersensitivity to NE infusion was observed in all patients. Head-up tilting (HUT) test resulted in no increase of plasma NE concentrations in both groups, but a significant increase of the plasma arginine vasopressin (AVP) concentrations in the patients with AF-PD. Urodynamic studies revealed that urinary bladder function was relatively well preserved in AF-PD in contrast to AF-MSA. In conclusion, there exists some clinical and physiological differences in autonomic features between AF-PD and AF-MSA, and postganglionic involvement predominates in AF-PD.
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PMID:Clinical and physiological characteristics of autonomic failure with Parkinson's disease. 1045 60

Objective. Freezing of gait (FOG) are the brief episodes of voluntary movement blocks in Parkinson`s disease and other variants of parkinsonism, which limit patient's mobility and decrease quality of life. Pathogenesis of FOG is still unclear. Authors studied characteristics of FOG in different stages of PD. Material and methods. Seventy patients were examined using different scales for assessment of clinical features. We measured the length, speed and cadence of gait and carried out a kinematic analysis of movements and stabilometry. Results and conclusion. FOG were found in 34.3% patients with PD, most of them were in advanced and late stages. FOG in off-periods were observed in 2/3 patients treated with levodopa, 1/3 of patients did not relate FOG with the periods of levodopa action. Turn and start FOG were noted more often. In patients with FOG, there were more expressed Parkinson's signs, especially axial symptoms, and more frequent urination disorders. The reduced speed of gait and asymmetry of gait were found as well. The kinematic analysis of gait revealed a correlation between the frequency of FOG and periods of support (and double support).
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PMID:[Freezing of gait in patients with Parkinson's disease]. 2504 2