Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Gastrointestinal symptoms caused by autonomic nervous system dysfunction has been well known in Parkinson's disease. This time we had a chance to see a patient with Parkinson's disease associated with acute abdominal pain because of gallstones. This study extended to examine abdominal findings in 79 cases of Parkinson's disease using abdominal ultrasound echography and also studied relationships between echographic findings and age, Hoen-Yahr stage and duration of the illness. Results were as follows: Echographic abnormalities were found 53.2% of the cases. Among them, gallstone was the most frequent findings and the incidence was 29.1% which showed significantly higher than that of the gallstone holding ratio (16.6%) in a age matched Japanese autopsy study. Subsequent findings were renal cyst (16.5%), renal stone (8.9%), liver cyst, portal dilatation and so on. No remarkable relationship was found between Hoen-Yahr stage and gallstone, however good correlation was found between duration of the illness and gallstone. It was concluded that gallstone holding ratio in Parkinson's disease is considerably high compared to that of a age matched Japanese autopsy study, which might be of great use in our daily clinics.
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PMID:[Gallstone and Parkinson's disease--ultrasound echography study]. 224 27

Long-term levodopa use is associated with the "End of Dose Wearing Off" (EODWO) phenomenon wherein Parkinsonian symptoms return before a patient's next scheduled dose of levodopa. Wearing off symptoms may include a variety of autonomic, emotional, motor, psychological and sensory abnormalities. Abdominal pain may be an important wearing off symptom as an early indicator of the development of EODWO in Parkinson's disease (PD) patients. In this report, we present two patients on levodopa therapy for PD who developed acute abdominal pain as a symptom of EODWO.
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PMID:Abdominal pain: a symptom of levodopa end of dose wearing off in Parkinson's disease. 2194 33