Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Parkinsonian tremor manifests in different types: rest, postural, and action tremors. The postural tremor occurs while a body part is held straight out from the body in a stable position against gravity. The Unified Parkinson's Disease Rating Scale (UPDRS), which is a subjective assessment performed by the qualitative judgment of neurologists, is the clinical standard for parkinsonian tremor assessment. Despite the common use of subjective methods, inertial measurement unit (IMU) sensors are largely used in many studies as a motion capture system to objective assessment of tremors. However, this kind of sensor must be attached to the patient's body, it limits the patient's movements and requires specific techniques for correct positioning in the limb. In this sense, non-contact capacitive (NCC) sensors are an alternative proposed in this research to record the motor activity of the hand and wrist during a pose against gravity. In order to assess the postural tremor and evaluate this novel sensing technology, data from ten subjects, five with Parkinson's disease (PD) and five neurologically healthy (H) matched in age and sex, were collected. We analyzed the instantaneous mean frequency (IMNF) of the signals from NCC and gyroscope sensors for both groups. The selected descriptive statistical variables allowed discrimination (p <; 0.05) among subjects from H and PD groups while using the gyroscope or the NCC sensor. The obtained results indicate that the NCC sensor can measure the postural hand tremor, and also that frequency features extracted from the collected signals can be used to discriminate subjects from both groups.
 ...
PMID:On the Use of Non-Contact Capacitive Sensors for the Assessment of Postural Hand Tremor of Individuals with Parkinson's Disease. 3194 52

Symptoms of Parkinson's disease (PD) caused by loss of dopaminergic neurons are accompanied by movement disorders, including tremors, rigidity, bradykinesia, and akinesia. Non-human primate (NHP) models with PD play an essential role in the analysis of PD pathophysiology and behavior symptoms. As impairments of hand dexterity function can affect activities of daily living in patients with PD, research on hand dexterity function in NHP models with chronic PD is essential. Traditional rating scales previously used in the evaluation of animal spontaneous behavior were insufficient due to factors related to subjectivity and passivity. Thus, experimentally designed applications for an appropriate apparatus are necessary. In this study, we aimed to longitudinally assess hand dexterity function using hand dexterity task (HDT) in NHP-PD models. To validate this assessment, we analyzed the alteration in Parkinsonian tremor signs and the functionality of presynaptic dopaminergic neuron using positron emission tomography imaging of dopamine transporters in these models. In addition, a significant inverse correlation between HDT and DAT level was identified, but no local bias was found. The correlation with intention tremor signs was lower than the resting tremor. In conclusion, the evaluation of HDT may reflect behavioral symptoms of NHP-PD models. Furthermore, HDT was effectively used to experimentally distinguish intention tremors from other tremors.
 ...
PMID:Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson's Disease. 3315 99

Previous studies have explored neurofeedback training for Parkinsonian patients to suppress beta oscillations in the subthalamic nucleus (STN). However, its impacts on movements and Parkinsonian tremor are unclear. We developed a neurofeedback paradigm targeting STN beta bursts and investigated whether neurofeedback training could improve motor initiation in Parkinson's disease compared to passive observation. Our task additionally allowed us to test which endogenous changes in oscillatory STN activities are associated with trial-to-trial motor performance. Neurofeedback training reduced beta synchrony and increased gamma activity within the STN, and reduced beta band coupling between the STN and motor cortex. These changes were accompanied by reduced reaction times in subsequently cued movements. However, in Parkinsonian patients with pre-existing symptoms of tremor, successful volitional beta suppression was associated with an amplification of tremor which correlated with theta band activity in STN local field potentials, suggesting an additional cross-frequency interaction between STN beta and theta activities.
 ...
PMID:Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients. 3320 52


<< Previous 1 2 3 4