Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study presents an approach to Parkinson's disease detection using vowels with sustained phonation and a ResNet architecture dedicated originally to image classification. We calculated spectrum of the audio recordings and used them as an image input to the ResNet architecture pre-trained using the ImageNet and SVD databases. To prevent overfitting the dataset was strongly augmented in the time domain. The Parkinson's dataset (from PC-GITA database) consists of 100 patients (50 were healthy / 50 were diagnosed with Parkinson's disease). Each patient was recorded 3 times. The obtained accuracy on the validation set is above 90% which is comparable to the current state-of-the-art methods. The results are promising because it turned out that features learned on natural images are able to transfer the knowledge to artificial images representing the spectrogram of the voice signal. What is more, we showed that it is possible to perform a successful detection of Parkinson's disease using only frequency-based features. A spectrogram enables visual representation of frequencies spectrum of a signal. It allows to follow the frequencies changes of a signal in time.
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PMID:Deep Learning Approach to Parkinson's Disease Detection Using Voice Recordings and Convolutional Neural Network Dedicated to Image Classification. 3194 97

Cerebral small vessel disease is a common condition linked to dementia and stroke. As an age-dependent brain pathology, cerebral SVD may share molecular processes with core neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Many neurodegenerative diseases feature abnormal protein accumulation and aberrant protein folding, resulting in multimerization of specific proteins. We investigated if a small NOTCH3 N-terminal fragment (NTF) that co-registers with pathologically affected cells in the inherited SVD, CADASIL, is capable of multimerization. We also characterized endogenous small molecule vascular enhancers and inhibitors of multimerization. NTF multimerizes spontaneously and also forms conjugates with vascular catecholamines, including dopamine and norepinephrine, which avidly promote multimerization of the protein. Inhibition of catecholamine-dependent multimerization by vitamin C and reversal by reducing agents implicate an essential role of oxidation in NTF multimerization. Antibodies that react with degenerating arteries in CADASIL tissue preferentially bind to multimerized forms of NTF. These studies suggest that multimerization of proteins in the aging brain is not restricted to neuronal molecules and may participate in age-dependent vascular pathology.
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PMID:Thiol-mediated and catecholamine-enhanced multimerization of a cerebrovascular disease enriched fragment of NOTCH3. 3211 34