Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty nine patients with neurogenic detrusor overactivity due to Parkinson's disease have undergone percutaneous tibial neuromodulation. The treatment consisted of percutaneous insertion of a 34-gauge solid stainless steel needle at a point of 5 cm cephald from the medial malleolus. The patients were treated weekly for 30 minutes. A subjective effect was assessed using a dairy and I-PSS score. Objective results were evaluated by cystometry. We observed a decrease in the average voiding frequency, number of leakage episodes after 12 sessions and 6 months of the tibial neuromodulation. An over 50% symptomatic improvement was achieved in 26 of 29 patients including 6 patients who were refractory to anticholinergic agents and 9 men with benign prostatic hyperplasia. Tibial neuromodulation is an effective treatment in patients with neurogenic detrusor overactivity due to Parkinson's disease.
 ...
PMID:[Tibial neuromodulation in the treatment of neurogenic detrusor hyperactivity in patients with Parkinson's disease]. 1705 70

Poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly(styrene sulfonate) (PSS) has a variety of chemical and biomedical applications. The application of PEDOT/PSS polymers in drug delivery has attracted attention. However, whether conducting polymers of PEDOT/PSS could be used for dopamine delivery has not clear. In the present study, the PEDOT/PSS coatings incorporated with dopamine were fabricated on 0.5 mm diameter platinum electrodes, electrochemical properties, and dopamine delivery capacities of these electrodes were evaluated in vitro and in vivo through implanting these electrodes into brain striatum area. The findings demonstrated that the PEDOT/PSS/dopamine coatings on platinum electrodes could reduce electrodes impedances, increase charge storage capacities, and release significant levels of dopamine upon electrical stimulation of these electrodes. These results indicated that polymers of PEDOT/PSS/dopamine could be used for dopamine delivery, implicating potential application of PEDOT/PSS/dopamine-coated implantable electrodes in the treatment of some diseases associated with dopamine deficits, such as, electrodes for the treatment of Parkinson's disease during deep brain stimulation.
 ...
PMID:In vitro and in vivo evaluation of poly(3,4-ethylenedioxythiophene)/poly(styrene sulfonate)/dopamine-coated electrodes for dopamine delivery. 2377 60

A novel fully organic bioelectronic device is presented and validated as electronic transducer and current stimulator for brain implants. The device integrates polymeric electrodes made of poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) on paper thin foils, resulting in a high surface-to-volume ratio architecture that exhibits high sensitivity to interfacial ionic transport phenomena. The prototyping technique herein presented yields devices for the bidirectional communication with biological systems whose dimensionality can be controlled according to the desired application. Transduction of ultra-low local-field potentials and delivery of voltage pulse-trains alike those used in deep-brain stimulation are herein assessed, paving the way towards novel theranostic strategies for the treatment of Parkinson's Disease and other severe neurodegenerative and/or traumatic pathologies of the central nervous system.
 ...
PMID:Exploiting interfacial phenomena in organic bioelectronics: Conformable devices for bidirectional communication with living systems. 2958 94

Alternating current stimulation (ACS) provides a versatile tool for modulating brain activity and presents a promising strategy for the treatment of neurological disorders like Parkinson's disease or epilepsy. Stimulation of neural tissue at low-frequency however poses new challenges on conventional electrode materials which support limited charge transfer in the desired frequency range, from less than 0.1 Hz to several tens of Hz. In our study we address this challenge by investigating the charge transfer properties of PEDOT/PSS coatings for low-frequency applications, focusing on the impact of the polymer bulk. PEDOT films of various thicknesses were exposed to low-frequency as well as DC stimulation textbfin vitro and compared to Pt and IrOx electrodes as controls. The charge injection performance of the metallic substrates could be substantially improved already by a thin PEDOT coating. Additionally a linear dependency between charge injection and polymer thickness suggests that PEDOT coatings are promising as materials for future ACS applications.
 ...
PMID:PEDOT as a high charge injection material for low-frequency stimulation. 3044 Aug 42