Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

W. Kostowski's The Pathomechanism and Pharmacotherapy of Parkinson's Disease was published in 1987. M. Weissel's Thyroid Gland Hormones Can Affect the Plasma Level of Atrial Urinary Sodium Peptide in Man was issued in Die Schilddruse in 1987. The following articles were published in the New England Journal of Medicine: 1. Madrazo's Microsurgical Graft of Adrenal Medulla to the Right Caudate Nucleus in Two Patients with Intractable Parkinson's Disease in 1987. R. Noore's Parkinson's Disease--A New Therapy? in 1987. F. Needelman's A Cardiac Hormone Intimately Involved in Fluid, Electrolyte, and Blood Pressure Homeostasis in 1986. G. Dersy's Arterial Endocrine Function in Humans with Artificial Hearts in 1987. W. Crowley's Progesterone Antagonism in 1986. B. Couzinet's Termination of Early Pregnancy by the Progesterone Antagonist RU-486 (Mifepristone) in 1986. Progesterone is indispensable for the maintenance of pregnancy; its elimination results in abortion. The progesterone antagonist RU-486, or mifepristone, which is a 19-nonsteroid, has been used lately for early pregnancy termination. A group of French and American authors conducted a study of 100 women with early unwanted pregnancy during 10 days following the end of expected menstruation. 34 women received 400 mg of RU-486 in the course of 4 days, 26 got 600 mg also in the course 4 days, and 40 women received 800 mg within 2 days. Uterine bleeding appeared in all women in the course of 4 days from the moment of giving the drug, and it lasted 5-17 days. A clear reduction of gonadotropin concentration was observed after 6 days. Ultrasound showed empty uterus within 13 days from the use of the drug. In 15 women after receiving RU-486, the increased level of gonadotropin lasted beyond 6 days, which was indicative of the lack of action of RU-486. In this group of women the uterine cavity was evacuated by nonpharmacological methods. The drug was safe and effective, although 15% of women did not react to it and significant prolonged bleeding occurred in 18% of them.
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PMID:[Progress in endocrinology]. 298 Sep 95