Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical assessment of postural instability in persons with Parkinson's disease (PD) is done with the retropulsive pull test, but since this test does not assess the underlying causes of postural instability, there is a need for additional assessment tools. The aim of this study was to identify postural sway parameters for use in a multifactorial approach to quantify postural instability. Nineteen adults diagnosed with idiopathic PD, 14 healthy age-matched controls (EH), and 10 healthy young adults (YH) completed the study. Postural parameters were extracted during quiet standing in eyes open (EO) and eyes closed (EC) conditions. Removing visual feedback affected the groups in a similar way. Significant differences between the PD and the two control groups were found in sway path length, area, and ranges in the anterior-posterior (AP) and medial-lateral (ML) directions and the Hurst exponents. PD significantly increased AP sway path length compared with YH and ML sway path length compared with EH. The Hurst exponents in PD were significantly different than in EH. The results suggest that the ML direction is a successful discriminator between PD and age-matched controls and that the interaction between ML and AP directions should be considered in the method used to quantify postural instability.
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PMID:Postural sway in patients with mild to moderate Parkinson's disease. 2174 Mar 7

Randomness of functional Magnetic Resonance Imaging (fMRI) resting-state time-series has recently been used as a biomarker for numerous disorders including Alzheimer's and Parkinson's disease as well as autism. To date, however, it remains unknown whether and to what degree personality traits are associated with the randomness of resting-state temporal dynamics. To investigate this question, we estimated the Hurst exponent - a measure of the randomness of a time-series - during resting-state fMRI in brain areas previously associated with trait Impulsivity as defined in Gray's Reinforcement Sensitivity Theory of Personality in 15 healthy individuals. The Hurst exponent in the ventral striatum as well as in the orbitofrontal cortex (OFC) was significantly associated with the measure of Gray's trait Impulsivity. Specifically, more random resting-state neural dynamics corresponded to higher Impulsivity scores both in the ventral striatum (r(15)=-.71; p=.003) and the OFC (r(15)=-.81; p<.001). In summary, we provide evidence for an association between individual differences in Gray's Impulsivity and randomness in key areas of the reward system which have previously been associated with this personality trait. Based on evidence from fMRI and electroencephalographical studies, we suggest that this association might arise from resting-state fluctuations constraining task-related neural responsiveness. Thereby, we outline a potential mechanism linking randomness of resting-state dynamics and personality.
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PMID:Randomness of resting-state brain oscillations encodes Gray's personality trait. 2188 90