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Target Concepts:
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Query: UMLS:C0030567 (
Parkinson's disease
)
63,064
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
A 77-year-old woman with
Parkinson's disease
presented with left chest pain. Physical examination revealed tenderness at her second left sternocostal joint. There was no skin rash. Chest CT revealed hyperostosis of the sternocostal joint, and cervical MRI showed vertebral osteosclerosis and osteolysis. 99mTc-MDP bone scintigraphy showed an increased activity in the sternocostal joint and vertebral column. The patient was diagnosed with SAHPO syndrome according to the diagnostic criteria. Her chest pain was relieved after oral administration of nonsteroidal anti-inflammatory drugs. Although pain is a common non-motor symptom of
Parkinson's disease
, chest pain is relatively rare, according to a previous reports. When patients with
Parkinson's disease
complain of chest pain, physicians should make an appropriate differential diagnosis after excluding emergent cardiovascular disease. To the best of our knowledge, this is the first report of
Parkinson's disease
associated with
SAPHO syndrome
. The relationship between the two diseases is unclear. However, peripheral inflammation is known to exacerbate ongoing neuronal damage in neurodegenerative diseases, such as
Parkinson's disease
. Therefore, systemic inflammation of
SAPHO syndrome
may affect the disease course of
Parkinson's disease
.
...
PMID:[Parkinson's disease associated with SAPHO syndrome: a case report]. 2971 19
