Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Magnetic cortical stimulation can produce silent periods (SP) following excitatory motor responses. In patients with Parkinson's disease (PD), a shorter SP was observed. The shortened SP in PD patients improved after levodopa administration. This shortened SP in PD patients may be related to the hyperactivity of the motor cortex, and to the dopaminergic system. In control subjects, sound stimulation produced prolongation of the SP at a time interval of 100 ms between sound and magnetic cortical stimulation-increase in the inhibitory function. However, the prolongation of the SP after sound stimulation was not observed in PD patients lack of an increase in the inhibitory function. Even after levodopa administration, sound did not prolong the SP in PD patients. The change of the auditory effects on the SP may be due to the abnormal function of the reticular formation in PD. This change might be independent of the dopaminergic system.
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PMID:Shortened silent period produced by magnetic cortical stimulation in patients with Parkinson's disease. 858 88

The effects of levo-dopa administration on the responses in the abductor pollicis brevis muscle after magnetic cortical stimulation, and on the auditory effects on the motor responses produced by magnetic cortical stimulation, were examined in eight patients with Parkinson's disease (PD). Levo-dopa administration did not change the amplitudes of the motor responses or the auditory effects on the motor responses produced by magnetic cortical stimulation. Not only the dopaminergic system, but also other neurotransmitter systems, may play a role in the motor disturbance of PD patients, at least advanced PD patients.
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PMID:The lack of dopaminergic effects on the motor responses produced by magnetic cortical stimulation in patients with Parkinson's disease. 895 69

When an health condition has been identified, the question of whether to continue driving depends not on a medical diagnosis, but on the functional consequences of the illness. The complex nature of physical and mental impairments and their relationship with safe driving make the availability of evidence based tools necessary for health professionals. The review aims at identifying and summarizing scientific findings concerning the relationship between neuropsychological and clinical screening tests and fitness to drive among people with chronic conditions. Studies were searched for driving ability evaluation by road test or simulator, clinical/neuropsychological examinations of participants with chronic diseases or permanent disablement impairing driving performance, primary outcomes as fatal/non-fatal traffic injuries and secondary outcomes as fitness to drive assessment. Twenty-seven studies fulfilled the inclusion criteria. Some studies included more than one clinical condition. The illness investigated were Alzheimer Disease (n=6), Parkinson Disease (n=8), Cardiovascular Accident (n=4), Traumatic Brain Injuries (n=3), Sleep Apnea Syndrome (n=2), Narcolepsy (n=1), Multiple Sclerosis (n=1) and Hepatic Encephalopathy (n=1), comorbidities (n=3). No studies match inclusion criteria about Myasthenia Gravis, Diabetes Mellitus, Renal Diseases, Hearing Disorders and Sight Diseases. No studies referred to primary outcomes. The selected studies provided opposite evidences. It would be reasonable to argue that some clinical and neuropsychological tests are effective in predicting fitness to drive even if contrasting results support that driving performance decreases as a function of clinical and neuropsychological decline in some chronic diseases. Nevertheless we found no evidence that clinical and neuropsychological screening tests would lead to a reduction in motor vehicle crashes involving chronic disabled drivers. It seems necessary to develop tests with proven validity for identifying high-risk drivers so that physicians can provide guidance to their patients in chronic conditions, and also to medical advisory boards working with licensing offices.
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PMID:Interventions to evaluate fitness to drive among people with chronic conditions: Systematic review of literature. 2265 63