Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030567 (
Parkinson's disease
)
63,064
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Lysosomes are key acidic Ca
2+
stores. The principle Ca
2+
-permeable channels of the lysosome are TRP mucolipins (TRPMLs) and NAADP-regulated two-pore channels (TPCs). Recent studies, reviewed in this collection, have linked numerous neurodegenerative diseases to both gain and loss of function of TRPMLs/TPCs, as well as to defects in acidic Ca
2+
store content. These diseases span rare lysosomal storage disorders such as
Mucolipidosis Type IV
and Niemann-Pick disease, type C, through to more common ones such as Alzheimer and
Parkinson disease
. Cellular phenotypes, underpinned by endo-lysosomal trafficking defects, are reversed by chemical or molecular targeting of TRPMLs and TPCs. Lysosomal Ca
2+
channels therefore emerge as potential druggable targets in combatting neurodegeneration.
...
PMID:Deviant lysosomal Ca
2+
signalling in neurodegeneration. An introduction. 2852 27
