Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We present an elderly patient with metastatic breast cancer and Parkinson's disease (PD) of moderate severity who developed paralytic ileus of protracted course after a low dose of 0.16 mg/m(2) intravenous vincristine. Since colonic myenteric plexus involvement occurs in PD, we suggest that it may predispose to vinca alkaloids-induced autonomic neuropathy. Vincristine should be used with caution in this clinical setup.
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PMID:Vincristine-induced paralytic ileus in Parkinson's disease. 1859 Oct 64

Parkinson's disease is a chronic progressive disease with symptoms of tremors, rigidity, and akinesia. Parkinson's disease is a major risk factor for postoperative complications and it is difficult to manage patients with Parkinson's disease after gastrointestinal surgery. This report presents the cases of three patients with Parkinson's disease who underwent gastrointestinal surgery and had no serious postoperative complications. Antiparkinsonian medications were reduced before surgery and replaced by an intravenous infusion of levodopa until the patients could take oral antiparkinson drugs after surgery to prevent malignant syndrome or exacerbate parkinsonism. Prokinetics were also used for the prevention of paralytic ileus. These cases demonstrate an effective method to administer antiparkinson drugs during perioperative management of patients with Parkinson's disease and also indicate that sufficient doses of antiparkinson drugs can control the symptoms of parkinsonism and prevent complications in cases of surgery with parkinsonism.
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PMID:Successful perioperative management of patients with Parkinson's disease following gastrointestinal surgery: report of three cases. 1977 80