Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030567 (Parkinson's disease)
 63,064 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two cases of acute hemorrhagic gastric necrosis are presented. The first patient was a 62 yr old man with a past history of chronic gastritis, Parkinson's disease and dementia. The second case was a 25 yr old woman with recent abuse of oral analgesic agents. Both presented with an acute abdomen and peritonitis, and underwent urgent gastrectomy for gastric necrosis with perforation. The first patient died, whereas the second recovered. Histology of the gastrectomy specimens showed severe hemorrhagic transmural gastric necrosis with minimal inflammatory changes. Only occasional Gram positive rods were seen in case 1, and microbiological cultures were negative. The etiology of the gastric necrosis in these 2 cases is unclear.
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PMID:Two cases of idiopathic acute gastric necrosis. 789 46

Helicobacter pylori is a human pathogen that can be found all over the world. It is responsible for the following diseases of gastrointestinal tube: gastritis, gastric ulcer, duodenal ulcer, gastric cancer, gastric lymphomas, Menetier disease. Some research has been done recently trying to identify the connection between H. pylori infection and idiopathic Parkinson's Disease morbidity. Some of them show that people with this neurological disease are more likely to have ulcers and also seropositivity in the direction of H. pylori. The direct influence of H. pylori infection on Parkinson Disease is not known but the following relations are suggested: H. pylori may produce toxins that damage substantia nigra in brain; possible cross reaction of h. pylori antibodies with dopaminergic neurons; indirect influence of antacids containing aluminium used to alleviate the symptoms of ulcers. Investigations of the reasons for idiopathic parkinson disease draw attention to the influence of food factors. Some researches show that there is a relation between the frequency of eating certain foods and the parkinson disease morbidity. We have numerous techniques that allow us to diagnose h. pylori infection. Those techniques have different sensitivity, accuracy, invasiveness and costs, which determines their usefulness in clinical diagnostics. Approach to eradication of bacteria is still discussed because H. pylori infection doesn't always lead to health problems. Polish Working Group on Helicobacter pylori, called by the National Consultant's Team on Gastroenterology explained clearly when eradication is advisable and when it can be waived.
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PMID:[Helicobacter pylori--does it only cause gastroduodenal disease?]. 1185 23

The persistent inflammation of the stomach induced by Helicobacter pylori infection can have consequences on the rest of the body. In the last few years, many studies have been performed on the implication of H. pylori in the pathogenesis of extra-gastric diseases attempting to establish if this association is real. Many diseases may be associated with H. pylori, e.g. vascular diseases, autoimmune diseases, skin diseases, sideropenic anemia, diabetes, Parkinson disease, and bronchiectasis. The number of important studies revealing such associations suggests that pathogenic mechanisms may link this infection with many diseases of unknown etiology. Unfortunately, the quality of the studies performed is not homogeneous, and more rigorous investigations are required to show whether a causal link exists between H. pylori infection and the pathogenic processes of these extra-digestive diseases.
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PMID:[Helicobacter pylori infection as a cause of extra-digestive diseases: myth or reality?]. 1270 May 3

The role of Helicobacter pylori (HP) in some digestive diseases (gastritis, ulcer, gastric cancer, MALT lymphoma) is well known. It has been suggested relatively recently that infection with HP can be involved in various extra-digestive conditions: respiratory disorders (chronic obstructive pulmonary disease, bronchiectasis, lung cancer, pulmonary tuberculosis, bronchial asthma); vascular disorders (ischaemic heart disease, stroke, primary Raynaud phenomena, primary headache); autoimmune disorders (Sjogren syndrome, Henoch-Schonlein purpura, autoimmune thrombocytopenia, autoimmune thyroiditis, Parkinson's disease, idiopathic chronic urticaria, rosacea, alopecia areata); other disorders (iron deficiency anaemia, growth retardations, liver cirrhosis). Case studies, small patient series and non-randomized trials that have shown a beneficial effect of HP eradication in different conditions are not convincing. According to Mastricht III the only conditions where HP eradication is indicated are immune thrombocytopenic purpura and iron deficiency anaemia.
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PMID:Extragastric manifestations of Helicobacter pylori infection. 1829 84

Abnormal tonic-motor activity is a key component in pathogenesis of many digestive disorders. Secondary disturbance of tonic-motor activity of digestive organs and the accompanying symptoms are known to develop in conjunction with diseases of other organs and systems, diabetes mellitus, Parkinson's disease, myotonic muscular dystrophy, amyloidosis, hyper- and hypothyroidism, hypoparathyroidism, etc. Disturbed motor activity in the gastro-duodenal region most frequently underlies functional dyspepsia, i.e. a group of symptoms unrelated to organic, systemic and metabolic diseases. Prokinetics are an important class of medicinal products for the treatment of all clinical forms of dyspepsia. One of the new ones is itopride hdrochloride having combined mechanism of action. Clinical studies of this drug revealed its high efficiency in patients with functional dyspepsia, chronic gastritis, and diabetic gastroparesis. It is well tolerated by the patients and produces no serious side effects. Inclusion of this drug in therapy improves the outcome of the treatment of disturbed motor activity of the gastrointestinal tract.
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PMID:[The use of prokinetics for the correction of motor and tonic digestive disorders]. 1946 57

Disorders of the gastrointestinal (GI) tract are common and distressing nonmotor symptoms of Parkinson's disease (PD) that can adversely affect levodopa absorption and lead to OFF periods, also known as motor fluctuations. Gastroparesis, which is primarily defined as delayed gastric emptying (DGE), and Helicobacter pylori infection, which is present with increased frequency in PD, are among the most common and important GI disorders reported in PD that may impair oral levodopa absorption and increase OFF time. Symptoms of gastroparesis include nausea, vomiting, postprandial bloating, fullness, early satiety, abdominal pain, and weight loss. DGE has been reported in a substantial fraction of individuals with PD. Symptoms of H. pylori infection include gastritis and peptic ulcers. Studies have found that DGE and H. pylori infection are correlated with delayed peak levodopa plasma levels and increased incidence of motor fluctuations. Therapeutic strategies devised to minimize the potential that gastric complications will impair oral levodopa absorption and efficacy in PD patients include treatments that circumvent the GI tract, such as apomorphine injection, levodopa intestinal gel delivery, levodopa inhalation powder, and deep brain stimulation. Other strategies aim at improving gastric emptying in PD patients, primarily including prokinetic agents.
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PMID:Clinical implications of gastric complications on levodopa treatment in Parkinson's disease. 3246 Oct 54