Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030552 (
paresis
)
5,831
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Recently,
parathyroid hormone-related protein
(
PTHrP
) was identified as one of the major causes of
humoral hypercalcemia of malignancy
in several species. The hormone probably has an important role in the physiology and pathophysiology of mammals and birds. Many endocrine, paracrine and autocrine functions are attributed to
PTHrP
. Parathormone shares the same receptor with
PTHrP
. This receptor was isolated in many tissues.
PTHrP
could be an important fetal growth factor. The influence of
PTHrP
on calcium homeostasis is presently the object of active research.
PTHrP
stimulates calcium transfer through the placenta and maintains a concentration gradient between the dam's blood and the fetus. The hormone is produced in large quantities in milk. However, its exact and principal function in lactation has not yet been determined. Among other effects,
PTHrP
might stimulate the secretion of calcium, phosphate and magnesium in milk and might foster the development of the mammary gland. A role of
PTHrP
in the pathogenesis of postparturient
paresis
in dairy cows has been hypothesized. Results of recent trials demonstrate that despite an important role in calcium homeostasis,
PTHrP
is not pivotal in the development of milk fever.
...
PMID:[Parathyroid hormone related-protein and calcium homeostasis]. 766 95
