Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Five of 34 hemophiliac children suffered from nine episodes of intracranial hemorrhage (ICH) from hemophilia A, and another 3 were B hemophiliacs. Diagnoses were confirmed by computed tomographic scan in all nine episodes. The ages of the patients with ICH ranged from 3 months to 4 1/2 years. The most frequent presenting symptoms were headache and vomiting, followed by focal neurological deficits. Eight of 9 episodes had bleeding in multiple regions. All the patients received immediate replacement therapy had recovered without surgical intervention. The duration of treatment was 10 +/- 2 days. All the patients survived and only one of them had neurological sequela as left hand paresis. From this observation we suggest that the treatment of suspected ICH in hemophiliacs should include prompt replacement therapy for either trauma or neurological symptoms in the absence of trauma history, documentation of ICH by computed tomographic scan, and prolonged replacement therapy and control of increased intracranial pressure in hemophiliacs with documented ICH.
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PMID:Intracranial hemorrhage in the hemophiliacs. 251 70

The clinical data of 59 patients with hemophilia A or B are reviewed. Intracranial bleeding was observed in 6 patients and a minor bleeding episode was assumed in a further 8 patients. Neurosurgical evacuation of the hematoma was necessary in 2 cases and the remaining patients were treated solely with factor VIII or IX. In 10 patients a peripheral nerve lesion was observed, paresis of the femoral nerve being the most frequent (5 cases). Two patients showed a lesion of the lumbar and sacral plexus, 2 patients a lesion of the radial nerve and one patient a lesion of the cutaneous femoris lateralis nerve.
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PMID:Neurological complications in hemophilia. 678 96

Postoperative malalignment after either a laminectomy or a laminoplasty in pediatric cases is a well-known complication. A 5-year-old boy with a history of hemophilia A presented with severe paresis. MRI showed an extensive epidural hematoma extending from C2 to T1. We performed decompression of the spinal cord using laminoplasty, preserving the insertion of the deep extensors. The patient completely recovered from the paresis. Even 7 years after the surgery we could not find any kyphotic deformities. The use of laminoplasty preserving the deep extensor musculature may be crucial for maintaining the postoperative cervical alignment in pediatric patients.
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PMID:Laminoplasty preserving the deep extensor musculature for a pediatric cervicothoracic epidural hematoma case of hemophilia A. 2515 44