Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We observed 24 patients with symptomatic neurosyphilis. Of these 24 patients, nine had clinical manifestations of general paresis, seven tabetic neurosyphilis, five meningovascular neurosyphilis, one taboparetic, one tabomeningovascular, and one spinal neurosyphilis. Confusion, disorientation, lancinating pain, impaired memory, and bizarre behavior were the most prevalent symptoms. Sensitivity of the CSF FTA-ABS test was higher (96%) than that of the CSF VDRL test (79%). CSF cell count and total protein determination may be inadequate for assessing activity of neurosyphilis.
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PMID:Symptomatic neurosyphilis. 666 3

Results of follow-up examinations of the CSF in 6 patients with neurosyphilis, including 5 with general paresis, following treatment with high doses of aqueous penicillin G are reported. Persistence of any residual active infection of the nervous system could be eliminated since as well as fairly rapid restoration of normal CSF cytology and chemistry there was a slow reduction (and sometimes return to normal) of initially very high levels of immunoglobulins G, disappearance of their oligoclonal distribution (3 cases), and negativation of quantitative immunofluorescence serology (F.T.A. ABS). Clinical efficacy of treatment was shown by stabilization of the intellectual deficit investigated by serial psychometric tests. Memory disturbances were prominent mainly in the initial stages, and sometimes adopted a rather frontal nature. Psychometric tests can contribute to the assessment of initial extension of the treponemic infection in the aborted types of general paresis. The atrophy observed constantly on CT scans appeared to be stationary on serial examinations (2 cases). It was of a diffuse type affecting cortical sulci and ventricles. The onset of anomalies such as ischemic complications was not related to recurrence of infection.
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PMID:[Biological, psychometric and tomodensitometric study of treated neurosyphilis]. 666 88

A 59-year-old male patient with general paresis was hospitalized because of personality changes and memory disturbances without any neurological deficits. His Mini Mental State score was 11, and his total IQ on the WAIS-R was 56. TPHA titers in serum and the CSF were over 40960x and 640x respectively. Both the white blood cell count as well as total protein were found to be increased in the CSF and FTA-ABS in the CSF was positive. The patient was treated with penicillin, one million units per day intramuscularly for 14 days, and four million units per day intravenously for 10 days. The abnormal findings in the CSF, his unstable mood and agitation improved, as well as his scores on the Mini Mental State (17) and total IQ (74), and the patient was able to once again function socially. This case emphasizes the importance of early diagnosis and treatment of general paresis.
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PMID:[A case of successful antisyphilitic treatment for a patient with general paresis]. 785 47

We reported a 32-year-old man with general paresis. He showed slowly progressive bradykinesia and recent memory loss. Argyll Robertson pupils were not present. Muscle strength and sensations were normal except for slight vibratory disturbance. Tendon reflexes were slightly exaggerated. MMSE, HDS-R and WAIS-R scores showed the intellectual impairment. His laboratory investigations revealed elevated both TPHA and FTA-ABS titers in the serum and the CSF. The CSF contained leukocytosis (25/mm3) and protein 80 mg/dl. Cranial CT and MRI demonstrated diffuse cortical atrophy. SPECT revealed marked reduction of the blood flow in bilateral cerebral hemisphere. Cerebral angiography revealed moderate stenosis of the major vessels. The diagnosis of neurosyphilis (general paresis) was made and the treatment of intravenous benzyl penicillin potassium 24 million units per day was started. After 6 weeks of the treatment, the clinical signs (includes MMSE, HDS-R and WAIS-R scores) and the findings of SPECT and cerebral angiography showed improvement. Although the cell count and protein in the CSF became decreased, the titers of TPHA and FTA-ABS in the serum and the CSF were not decreased. Neurosyphilis should always be considered in a etiologically unknown case with bradykinesia and dementia.
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PMID:[Therapeutic case of general paresis manifested by bradykinesia and recent memory loss]. 1061 61