Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

With a rate of 0.5-1/1,000 of the total number of births in West Germany, spina bifida is next to cerebral paresis one of the most frequent congenital defects. Altogether, fifty places in special schools are needed per one million of inhabitants for spina bifida children. The loss of physical unctions is comparable to that in the case of paraplegia. The variety of medical and psychological problems makes the cooperation of highly different branches of study indispensible in a rehabilitation team (neurosurgeon, neuropediatrician, urologist, orthopaedist, pediatrician, educator, social worker, physical therapist). Each team member must be informed about the complete rehabilitation plan. These children's shortage of environmental experience is mainly due to their backwardness as regards motoric development, which cannot be recovered by means of individual physical therapy alone. On the other hand, additional, specifically selected and organised physical education makes possible the necessary mobility and social experiences. By giving the children exercises suitable for their ages it is hoped to achieve a late maturation and stabilization of the personality. In choosing the exercises it is first of all necessary to go back to the so-called fundamental activities like climbing, hanging by one's hands, sliding, pushing oneself up off the ground, swinging or throwing and catching, before going on to wheel-chair sports. Wheel-chair sport promises a varied selection for group exercises (games) and for everyday use. Using the wheel-chair as sports equipment, it is possible for persons with other types of locomotive handicaps to be integrated into the group. For physical education in special schools the pupils whould be arranged into groups according to their ability in order to keep the groups as homogenous and the children's chances as equal as possible. The most important teaching criteria are in this case: the creation of a happy atmosphere, a high degree of clarity, the fulfilment of individual inclinations, the encouragement of independence, the development of community life and the fulfilment of everyday tasks. In swimming, the spina bifida child differs from the normal child in his greater initial fear and in the existence of contractions, a scoliosis, hyperlordosis or -kyphosis due to the resultant instability of the water. Because of this, specifically oriented swim- and work-aids must be used. The didactic procedure is then the same as in the case of normal children. After the child's familiarity with and safety in the water is assured, one can proceed to individual swimming techniques and in a few cases to sport swimming. Bacteriological examination of the water did not yield any results which could cause objection on the grounds of hygiene.
 ...
PMID:[Physical education for spina bifida children in special schools for the physically handicapped (primary school)]. 15 44

Disturbances of bladder, function often occur in cases of sciatica due to intervertebral disc lesions, although other clinical signs of sacral root compression are absent. In 32 patients, operated upon because of lumbar disc diseases without cauda equina syndrome, micturition symptoms were registered, and bladder function was investigated. Intravesical pressure/volume relations (water cystometry) and simultaneous intravesical pressure/urinary flow relations (urodynamic examination) were recorded preoperatively together with anal sphincter surface EMG. In almost half of the patients cystometry revealed bladder hyposensibility (late first sensation), and a quarter voided mainly by straining (detrusor paresis). These findings were unrelated to the neurosurgical pathology. Pronounced micturition symptoms or abnormal preoperative urodynamic examinations indicated evaluation two months after lumbar disc operation. Two-thirds tended towards recovery, one third remained unchanged.
 ...
PMID:Bladder neuropathy in lumbar disc disease. 46 3

Estonian shale oil contains about 25--30% phenols, and their action determines the toxicity of shale oils. The clinical symptoms of intoxication are rather similar, regardless of route of administration. Due to neurotropic action, the coordination of movements is impaired, and clonic and tetanic convulsions, paresis and paralysis of extremities, and narcosis are observed. In subacute and chronic toxicity tests, dysfunction of the central nervous system was found. In long-term (4--6 month) experiments, changes in liver and kidney function were found. Shale oil has gonadotropic activity and causes changes in the sexual cycle as well as diminution of the number of primordial folicles in the ovaries or a decrease in the quantity of normal spermatogonia in testicular germinal epithelium. Shale oils produce local irritation of skin and mucous membranes. Shale oil can induce sensitization of the organism after repeated administration. The results of acute intoxication tests have proved that volatile and nonvolatile phenol fractions, isomeric dimethylphenols, and 5-methylresorcinol, must be characterized as moderately toxic substances; the LD50 ranges from 501 to 1500 mg/kg. The clinical symptoms of acute toxication are similar for all studied phenols (restlessness, unsteadiness, clonic tremor, paresis and paralysis of extremities, and death). In spite of the moderate toxicity of phenols in acute experiments, repeated administration of small doses can cause different changes in the nervous system and internal organs of experimental animals. For all the phenols studied, the maximum allowable concentration in water was limited by their effect on the organoleptic properties of water. The nonactive dose for warm-blooded animals is from 100 to 3000 times the threshold limit value of phenols on the basis of their organoleptic properties. The effect of commercial products of oil shale industry is generally determined by the toxicity of the main components: water-soluble oil shale phenols.
 ...
PMID:Toxicological studies of shale oils, some of their components, and commercial products. 57 2

Eleven immature adult Angiostrongylus cantonensis were recovered from beneath the meninges of a captive Bennett's wallaby (Macropus rufogriseus) which died after displaying posterior paresis followed by paralysis and intermittent opisthotonic spasms of increasing frequency for 7 days. Congestion and focal malacia with haemorrhage were seen in the brainstem and cerebellum. Sections of worms with scanty inflammatory response were seen beneath the congested haemorrhagic leptomeninges of cerebrum and in a cerebellar folium. Infection was thought to have originated from feed or water contaminated with larvae released from a molluscan intermediate host.
 ...
PMID:Angiostrongylus cantonesis infection of the brain of a captive Bennett's wallaby (Macropus rufogriseus). 65 84

The use of air as the caloric medium was investigated and compared to that of water. The ability of air and water to generate surface temperatures close to the fluid outlet temperature was studied by irrigation onto a thermocouple. Results of caloric tests performed with air and water are compared by calculating the average nystagmus response for the hot and cold stimuli for two groups of sixty patients. Also, the number of canal paresis, directional preponderance, mixed, bi-lateral canal paresis and normal responses are compared for each group. Finally, the effect of performing a bi-thermal air caloric on a patient having a unilateral drum perforation is discussed.
 ...
PMID:Air as the caloric stimulus. 66 96

Recurring episodes of extreme leg weakness and associated mortality were documented in a turkey flock at 8 to 15 weeks of age. Flock mortality attributed to posterior paresis was approximately 12%, or 4800 of 40,000 turkeys. Four of six open-confinement units were affected. Gross and histological examinations revealed no significant lesions. Immunology and virology were uninformative. There were no significant differences in serum chemistry between clinically affected and normal turkeys. Testing of feed, water, soil, and tissues revealed no common toxicants. Isolation and supportive care for affected turkeys, both in the laboratory and in the field, frequently resulted in full recovery. Injection of a test group of affected turkeys with Type C botulism antitoxin appeared to enhance recovery. However, repeated attempts to detect botulism toxin in serum, liver, or cecal contents using mouse bioassay procedures were unsuccessful.
 ...
PMID:Recurrent transient paresis in a turkey flock. 141 11

The authors show that application of anticipated postoperative intensive care gives the possibility ot obtain more complete effect of compensation. The basic components of this therapy are the following: removal of hypovolemia and anemia, combined (central and regional) anesthesia, prevention of pneumonia, normalization of salt and water exchange, removal of excessive catabolism, adequate ensuring of organism with energy and plastic material for long-time compensation, prophylaxis and treatment of paresis of digestive tract, chemoprophylaxis of wound infection. The proposed program of intensive therapy gives the possibility to minimize the lethality among wounded with penetrating abdominal gunshot injuries and can be used as a basic one for the development of various schemes of intensive therapy for other categories of wounds.
 ...
PMID:[Postoperative intensive therapy in penetrating gunshot wounds of the abdomen]. 157 Jun 95

The term "caloric irregularity" was coined to refer to a gross irregularity in the amplitude and/or frequency of a caloric-induced nystagmus, having a variable slow-phase velocity and prolonged duration. Twelve of 46 guinea pigs with experimentally induced perilymphatic fistula had irregular responses to the ice-water caloric test 1 week after creation of a fistula. The long-term vestibular consequences in animals with caloric irregularities were either resolution and return to normal function (i.e. caloric return) or continuing deterioration to canal paresis. Morphological examination of ears with caloric irregularity revealed that there had been partial collapse of the membranous labyrinth and the creation of a floating labyrinth.
 ...
PMID:Caloric irregularity in experimentally induced perilymphatic fistula. 164 73

Before the onset of bovine paresis a stage of hyperactivity and hypersensitivity was observed in clinical as well as in immunologically provoked cases. By gas chromatographic analysis of choline (Ch) in plasma and serum from four immunologically provoked cows this stage was verified to be an initial immuno-cholinergic hyperactivation. In the first hour after antigen challenge with 0.5 mg nematode AChE there was a very sharp rise in Ch mainly from agonist-stimulated and phospholipase mediated phosphatidylcholine (PC) breakdown. A secondary massive influx of Ca into cells was mirrored in a 1 mmol/l depression of serum-Ca values during the first hours. The hyperagonism mediated Ca-translocation brought water into cells, resulting in reduced plasma volume. The generally supposed mechanism of secondary, Ca-mediated cell damage and cell death was initiated and sometimes resulted in "Downers" with persisting paralysis. All acetylcholine (ACh)-stimulated parts from CNS to the periphery are irregularly involved explaining the very varied clinical appearance of bovine paresis, and the influence on for instance the autonomous nerve system, adrenals and pancreas. In the experimental group, ACh in plasma showed a sharp fall within the first hour, while there were fairly constant values of serum-ACh in the first four hours, possibly indicating some antibody protection. When paresis was established between 15-28 hours after challenge the general anergetic state was characterised by low ACh-levels. Also in a larger field group ACh-levels were significantly depressed in paretic compared to healthy cows. The unexpected finding in this group was considerably higher levels of ACh and especially Ch in serum compared to plasma. The origin of ACh and Ch had to be blood cells. Preliminary gas chromatographic analysis has confirmed ACh-synthesis by leucocytes and an integrated immuno-cholinergic system of great importance can be anticipated. The general feature of bovine paresis is updated by immune-etiological, pathophysiological, blood chemical, clinical-experimental and nomenclature considerations. The exact mechanism of pathogenesis is not revealed in this investigation, though many circumstances favour an anti-Id mediated hyperagonism. Other types of investigations and above all more basic knowledge of distribution and functional character of cholinergic components on immune cells are required.
 ...
PMID:Origin and significance of acetylcholine and choline in plasma and serum from normal and paretic cows. 179 76

Hydrogen peroxide is used as a preserver in milk industry. Three cases of accidental ingestion of 60% hydrogen peroxide (oxygenated water 200 volumes). The patients were male stockbreeders aged 30, 45 and 62 years, respectively, who stored that powerful oxidizing agent in commercial drink containers without adequate labeling. One of them was admitted comatose and required assisted ventilation. After recovering consciousness migratory paresis of right limbs and of the VI cranial nerve were observed, which were reversed after ten days, and left hemiparesia that persisted for two months. Upper gastrointestinal tract lesions, particularly in stomach, were detected in all. The endoscopic and pathological findings are described in detail. The outcome was satisfactory in the three patients, with complete remission of the lesions. There appears to be a direct relationship between the severity of symptoms and the amount of ingested peroxide, dependent on the diameter of the opening of the container. Only five reports have been identified related to the oral poisoning by this substance.
 ...
PMID:[Ingestion of hydrogen peroxide. Apropos of 3 cases]. 204 3


1 2 3 4 5 6 Next >>