Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hydrogen peroxide is used as a preserver in milk industry. Three cases of accidental ingestion of 60% hydrogen peroxide (oxygenated water 200 volumes). The patients were male stockbreeders aged 30, 45 and 62 years, respectively, who stored that powerful oxidizing agent in commercial drink containers without adequate labeling. One of them was admitted comatose and required assisted ventilation. After recovering consciousness migratory paresis of right limbs and of the VI cranial nerve were observed, which were reversed after ten days, and left hemiparesia that persisted for two months. Upper gastrointestinal tract lesions, particularly in stomach, were detected in all. The endoscopic and pathological findings are described in detail. The outcome was satisfactory in the three patients, with complete remission of the lesions. There appears to be a direct relationship between the severity of symptoms and the amount of ingested peroxide, dependent on the diameter of the opening of the container. Only five reports have been identified related to the oral poisoning by this substance.
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PMID:[Ingestion of hydrogen peroxide. Apropos of 3 cases]. 204 3

This study used chemiluminescence, an "on-line" photon-counting technique, to detect and characterize activated O2 species in vitro and in isolated rat lungs. The sensitivity and specificity of enhanced chemiluminescence for superoxide anion (O2-.) and hydrogen peroxide (H2O2) was evaluated in vitro. The effect of media conditions (such as O2 tension, albumin concentration, and sulfhydryl group availability) on luminescence was assessed in vitro. Xanthine-xanthine oxidase (X-XO) primarily produced superoxide anion in vitro. Enhanced chemiluminescence varied directly with the dose of luminescent probe used and the quantity of activated O2 species administered. The strength of the luminescent signal was also dependent on the concentration of albumin and O2 in the media. Lucigenin was more sensitive than luminol to the presence of O2-. and, unlike luminol, lucigenin did not alter radical production by XO. However, neither luminescent probe was specific for O2-., as both detected H2O2 and O2 in vitro. H2O2-induced chemiluminescence was inhibited by catalase but not superoxide dismutase (SOD), while X-XO-induced luminescence was inhibited by SOD but not catalase. SOD-inhibitable chemiluminescence was a sensitive and specific marker for O2-. production in vitro. Once the sensitivity-specificity of enhanced chemiluminescence was defined in vitro, this technique was used to explore the mechanism by which exogenous X-XO reduced hypoxic vasoconstriction in isolated rat lungs. The vascular paresis, caused by administration of X-XO to the rat lung, resulted from a brief burst of O2-. production rather than a sustained alteration of lung radical levels.
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PMID:Detection of activated O2 species in vitro and in rat lungs by chemiluminescence. 253 94