Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A new method of collagen-normalizing therapy has been worked out to prevent specific anesthesia-induced, operative and postoperative complications and to treat some symptoms in children with Ehlers-Danlos and Marfan's syndromes and with non-classified Marfan-like malformations. The technique involves a combined use of beta-adrenoblocker in the age-matched doses and vitamins C/0.03 g/(kg.day)/, B2/0.0004 g/(kg.day)/and B6/0.002 g/(kg.day)/ for 2.5 months before surgery and during the first 2 weeks of the postoperative period. The above therapy reduces the incidence of delayed recovery of the muscular tone and adequate respiration, spontaneous and recurrent pneumothorax, hemorrhagic and gastroenterologic complications, as well as the incidence and severity of intestinal paresis. The indexes of effective collagen-normalizing therapy are as follows: body weight increase, echocardiographic pattern of reduced diameter of the aorta and mitral valve prolapse, normalization of the urinary excretion of total and polypeptide-bound oxyproline. The efficacy of therapy depends on the baseline level of oxyproline excretion.
 ...
PMID:[The effect of collagen-normalizing therapy on the incidence and severity of anesthetic and postoperative complications in children with connective tissue syndromes]. 239 60

Partial cystectomy was performed for myogenic decompensated bladder with excessive residual urine in 11 patients, in whom training instructions and pharmacological treatment were unsuccessful. Postoperatively, the patients were followed for 2-13 years (median 4 years). Both symptoms and residual urine were reduced permanently. Urodynamic testing had demonstrated underactive detrusor function in all. The supposed etiology was infravesical obstruction in 4, overdistension due to sensory bladder paresis in 3 and unknown in 4. Histological examination of the resected bladders showed focal degeneration of the smooth muscle cells (detrusor myopathy) in 7, transmural edema and vast deposits of collagen in 8, mastocytosis in 3 and eosinophilic cystitis in 1. In conclusion we regard partial cystectomy an alternative to clean intermittent self-catheterization in selected patients with excessive residual urine.
 ...
PMID:Partial cystectomy for the myogenic decompensated bladder with excessive residual urine. Urodynamics, histology and 2-13 years follow-up. 323 29

Augmentation of a vocal fold serves to improve glottic closure and may be indicated for paresis of the recurrent nerve and after tumor resection. Methods include injection of viscous fluids (paraffin, liquid silicone, polyvinyl alcohol, gelatin, sesame oil, collagen and particularly teflon paste) and operations to tighten the vocal cord or displace it medially. The disadvantages of the former include the danger of overcorrection, tissue irritation and possible systemic absorption of the material. As an alternative, solid material such as cartilage or synthetics may be used for augmentation. Experience obtained so far has shown that chips of porous polyethylene (PHDPE) are particularly suitable: they are easy to use, show good tissue tolerance and are anchored by ingrowth of connective tissue. The value of photokymography of the larynx in the assessment of therapeutic results after vocal-fold augmentation is discussed.
 ...
PMID:[Experiences with the augmentation of vocal cords]. 330 34

Urinary excretion of total hydroxyproline being an indicator of the metabolism of systemic collagen was determined in 104 patients with ischaemic stroke and in 45 controls. The determinations were done by the method of Prockop-Udenfried in the urine of patients after 2 days on a non-collagen diet. Increased excretion of hydroxyproline was found in the subgroup of patients with high-grade paresis or paralysis, while in the subgroup with mild paresis these results were normal. The excretion of hydroxyproline in patients with severe paralysis increased during 3-60 days after stroke and then decreased in the period from 60 days to 5 years.
 ...
PMID:[Urinary excretion of hydroxyproline in patients with ischemic stroke]. 338 Feb 61

Total urinary hydroxyproline was determined 79 times by the Prockop-Udenfried method in 61 patients with multiple sclerosis. All patients had the pyramidal syndrome. Depending on the intensity of paresis at the time of the study the patients were divided into two groups: Group I--patients with slight paresis. Group II--patients with major paresis or paralysis. The control group comprised 45 healthy subjects. The mean urinary hydroxyproline excretion was in both groups as a whole and in each group separately not different significantly from that in the control group. The values of hydroxyproline excretion depended on the duration of paresis, and were highest in both groups 2 weeks to 1 year after the onset of paresis, and then they decreased in two successive time periods: 1-5 and 5-17 years of the disease. The values of hydroxyproline excretion were significantly above the control level only in patients with severe paresis or paralysis of up to 1 year duration, and might have been due to increased catabolism of collagen in the bones of the paralysed extremities in the period of the so called acute osteoporosis.
 ...
PMID:[Urinary excretion of hydroxyproline by patients with multiple sclerosis]. 340 86

Chronic Aspergillus meningitis and cerebral vasculitis occurred in a 67-year-old man. He experienced periorbital pain that increased in severity during a ten-month period. Although no focal neurologic deficits were initially present, oculosympathetic paresis, corneal hypesthesia, and optic neuropathy developed. This is the first report, to our knowledge, of paratrigeminal syndrome with optic neuropathy due to aspergillosis. The case was also unusual because it was chronic and there was no extracerebral infection or predisposing factors, such as underlying malignancy or collagen vascular disease.
 ...
PMID:Optic neuropathy and paratrigeminal syndrome due to Aspergillus fumigatus. 711 50

Twenty-six cases of adult T-cell leukemia/lymphoma (ATLL) were identified between 1983 and 1991 in Martinique (French West Indies). There were 14 men and 12 women, all of mixed racial descent and born in Martinique. Their ages ranged from 23 to 95 years. The main clinical and laboratory features at initial presentation were peripheral lymphadenopathy (22 cases), hepatomegaly (11 cases), splenomegaly (10 cases), cutaneous lesions (12 cases), hypercalcemia (16 cases), refractory infection by Strongyloides stercoralis (12 cases), and pre-existing autoimmune disorders (4 cases). All patients had absolute lymphocytosis with circulating pleomorphic abnormal lymphocytes. The prognosis was poor, with most patients (20 cases) surviving for less than 6 months. Although the overall clinicopathologic features of ATLL in this series are similar to those described in previous reports, we observed three additional points of interest: a high association with Strongyloides infection, an increased incidence of tropical spastic paresis/HTLV-1 associated myelopathy (TSP/HAM) among the relatives of the patients (5 cases), and the presence of prior collagen vascular diseases.
 ...
PMID:Adult T-cell leukemia-lymphoma: a clinico-pathologic study of twenty-six patients from Martinique. 811 52

The collagen metabolites hydroxyproline (HYP), deoxypyridinoline (DPD) and pyridinoline (PYD) are suitable markers for bone resorption in humans and several animal species. In a field trial cows with symptoms of periparturient paresis (group A) and healthy control cows without symptoms (group B) were compared and urine and blood samples were collected on day 1, 2, 3, 4, 5, 9 and 14 after parturition. In group A the mean +/- SE serum Ca concentration on day 1 was 1.4 +/- 0.1 mmol/l whereas those of group B were 2.0 +/- 0.1 mmol/l. A significant increase of the corrected urinary HYP concentration was observed from parturition to day 14 (from 2.8 to 8.8 mumol/mmol creatinine) and the concentrations at the different times were higher in group A than in group B. The mean corrected total and free DPD and total PYD concentration in urine increased after parturition to reach a peak at day 9. For DPD and PYD the mean concentrations between the two groups did not differ significantly. The DPD and PYD are useful tools to follow bone resorption in dairy cows, although in our study no difference between the two groups could be found which means that both groups were able to mobilize Ca from bone.
 ...
PMID:[Determination of bone markers in dairy cows with parturient paresis]. 980 60

This study investigated whether hydroxyproline, deoxypyridinoline, or the carboxyterminal telopeptide of type I collagen could be used as markers to provide evidence of bone resorption during hypocalcemia of dairy cows. Serum concentrations of the amino-terminal propeptide of type III procollagen were also analyzed to study the effect of parturition on type III collagen, which is a component of soft connective tissues. Urine and blood samples were collected on d 1 to 5, on d 9, and d 14 after parturition from 18 cows with symptoms of periparturient paresis (group 1) and 19 healthy control cows without symptoms (group 2). Urine concentrations of hydroxyproline and deoxypyridinoline were measured with a colorimetric assay and an enzyme immunoassay, respectively. Serum concentrations of the amino-terminal propeptide of type III procollagen were measured using a commercially available radioimmunoassay. A radioimmunoassay was developed to analyze serum concentrations of the carboxyterminal telopeptide of bovine type I collagen. The mean corrected urinary hydroxyproline concentrations in group 1 increased from parturition to d 14; concentrations in group 1 were significantly higher for group 2 after d 5. Mean corrected deoxypyridinoline concentrations in urine increased after parturition to reach a peak at d 9, and serum concentrations of the carboxyterminal telopeptide of type I collagen peaked at d 5. However, mean concentrations of deoxypyridinoline and the carboxyterminal telopeptide of type I collagen did not differ significantly between groups. The variation in the behavior of the three markers is likely a reflection of the different phases and aspects of the bone collagen degradation. In conclusion, assays for urinary deoxypyridinoline and serum carboxyterminal telopeptide of type I collagen determinations are useful tools to follow the course of degradation of bone collagen in dairy cows.
 ...
PMID:Comparison of bone resorption markers during hypocalcemia in dairy cows. 981 67

The collagen metabolites hydroxyproline (HYP), deoxypyridinoline (DPD), and the carboxyterminal telopeptide of type I collagen (ICTP) are suitable markers for bone resorption in humans and several animal species. The purpose of this study was to describe the course of bone resorption markers during short-term hypocalcemia induced with disodium ethylenediaminetetraacetic acid (Na2EDTA) and to investigate whether bone resorption is increased in dairy cows under these conditions. EDTA infusions have been used as a model for periparturient paresis in dairy cows and to estimate the calcium mobilization rate from body reserves in ruminants. In this study, hypocalcemia was induced by means of a 5% Na2EDTA infusion (0.55 mg/kg/min Na2EDTA for 5 h = total dose of 100.6 g). Two experiments were conducted: (1) Six 4-11 years-old Brown Swiss cows were infused intravenously with EDTA for 5 h. Blood and urine samples were taken repeatedly from 1 day before until 10 days after infusion. (2) Towards the end of the lactation, the experiment was repeated with the same animals after a 14-day-period of feeding a low calcium diet (26 g/animal per day). The EDTA-infusion induced hypocalcemia and hypophosphatemia. The HYP-, DPD- and ICTP-concentration remained mainly unaffected during both infusions. Only DPD showed an increase during infusion and HYP an increase 2 days after the infusion. In conclusion, the EDTA infusion had little effect on the concentrations of the measured bone markers, which may be due to the fact that the serum calcium pool was refilled by increased absorption of Ca via the gastrointestinal tract. From these results, it can be concluded that bone resorption was not influenced by EDTA infusion.
 ...
PMID:The course of selected bone resorption marker concentrations in response to short-term hypocalcemia experimentally induced with disodium EDTA infusions in dairy cows. 1107 39


1 2 Next >>