Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Clinical analysis of 378 acute cases of Malathion insecticide intoxication and pathological and histochemical investigation of skeletal muscles in 7 autopsied victims of acute poisoning have revealed the pronounced neuromuscular disorders. Generalized paresis and paralysis of muscles were observed in trunk and limbs. Muscular fasciculation, hypotonia and hyporeflexia were also generalized. Multiple foci of muscular fibers necrosis and necrobiosis were found with intermuscular nerves and motor endings degenerated, neuromuscular junctions cholinesterase sharply inactivated.
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PMID:[Clinico-morphologic and histochemical changes in the neuromuscular apparatus in acute carbophos poisoning]. 318 79

Clinical manifestations of chronic intoxication due to organophosphorus pesticide (OP) and treatment by prifinium bromide, an anticholinergic drug (Padrin), have been introduced. All patients showed oculopathy, mainly neuro-ophthalmological impairments such as: 1. optic neuropathy, 2. degeneration of the retina, 3. defective vertical smooth pursuit, 4. myopia; spasm or paresis of accommodation with or without corneal astigmatism "with the rule" and mild general neurological impairments. These manifestations were more severe among children than in adults, who were environmentally exposed mainly to 3% Malathion sprayed by helicopters several times a year for over 3-5 years. Presumed intake of Malathion for a given child is a far lower dosage than considered previously. Padrin (prifinium bromide) with vitamin B12, C, and E were effective in regressing oculopathy exposed environmentally to OP pesticides.
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PMID:Chronic intoxication of organophosphorus pesticide and its treatment. 790 89