Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The dynamic state of hematoencephalic barrier (HEB) was estimated in Russian tick-borne encephalitic (RTBE) and in meningeal syndrome (Lyme's disease, LD). The enzyme immunoassays of neurospecific proteins in blood serum such as alpha 1-BG and enolase (NSE) were performed in the course of disease. The break of HEB at blood-brain direction was proved in patients with RTBE and LD for the proteins mentioned above. The blood serum NSE levels as well as their dynamics confirmed the functional alteration of brain neurons' permeability in LD and pronounced destruction of such neurons in RTBE. The acute increase of blood NSE concentration was observed within some days before the development of clinical signs of paresis. The authors suppose that the enzyme immunoassays of neurospecific proteins which are of rather high value for HEB permeability and neuronal destruction control may be successfully applied in monitoring of both therapy's efficacy and individualization of pharmacotherapy.
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PMID:[Resistance of the hemato-encephalic barrier in tick-borne neural infection (Lyme disease and tick-borne encephalitis)]. 878 74

Transverse myelitis is a disease with various pathogenesis. It leads to a partial or total transverse lesion of the spinal cord structures resulting in an acute or subacute: motor (paralysis or paresis), sensory (most often with sensory level) and autonomic symptoms and signs. Its etiology is complex and sometimes difficult to establish explicitly. The most frequent reason of transverse myelitis is infection, but there are other factors like: postinfectious, neoplastic, paraneoplastic, demyelinating, immunological (connective tissue diseases), vascular and others. Idiopathic transverse myelitis accounts for about 10-40% of cases, and despite thorough diagnostics its aetiology cannot be established. Transeverse myelitis has been known for years, but it still poses a big problem both diagnostically and therapeuthically. Its course is frequently serious leading to persistent neurological damage and permanent disability. Diagnostic methods of choice are spinal cord MRI and CSF examination with assessment of oligoclonal bands, biomarkers of inflammatory process, 14-3-3 protein and neuronal specific enolase. Its treatment is determined by established aetiology. Many inconsistencies, no clear cut definition of the disease and lack of diagnostic criteria are being discussed by the group of experts working in Transverse Myelitis Consortium Group.
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PMID:[Transverse myelitis]. 2232 33