Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An increase in content of serotonin, histamine, the elevated histaminase activity in tissues and an increase in excretion of 5-hydroxyindolylacetic acid with urine were observed in experimental botulism, accompanied by paresis of sceletal muscles. As the paralysis progressed content of histamine gradually decreased in nervous tissue but it remained to be increased in the internal tissues although the histaminase activity was high. At the same time, content of serotonin was maintained at an increased level in the nervous tissue, but it was normalized in several internal organs. Excretion of 5-hydroxyindolylacetic acid with urine was decreased. LD50 of botulinic toxin was titrated in mice, which were simultaneously administered with preparations increasing or decreasing the synthesis and the activity of biogenic amines. The data obtained suggest that the impairments in metabolism of biogenic amines could be important for development of the intoxication.
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PMID:[Change in biogenic amine metabolism in botulin poisoning]. 82 91

Some types of anesthesia, used usually in labor anesthesia (sodium hydroxybutyrate, lexir) or in abdominal delivery (neuroleptanesthesia, cetalar narcosis, electroanesthesia) did not affect distinctly the activity of amine oxidases in blood sera of women in labor and of fetus. In some groups of women in labor the neonates were found, blood serum of which exhibited high activity of diamine oxidase, not observed in normal state. A slight decrease in deamination of benzylamine (20%) and 4-nitrobenzylamine (30%) was observed in patients with gynecological diseases within 2 and 3 days after operations. If intestinal paresis developed in the patients within the postoperational period deamination of these substrates was decreased by 75-80% in blood sera. After 2-4 courses of hyperbaric oxygenation a slight but statistically distinct decrease (by 22-25%) in the rate of deamination of benzylamine and 4-nitrobenzylamine was found in blood sera of the patients.
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PMID:[Changes in the amine oxidase activity of human serum during different types of anesthesia and hyperbaric oxygenation]. 308 35