Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-nine documented cases of cerebellar degeneration at the National Taiwan University Hospital during a 8-year period (1980 through 1987) were reviewed. They were classified as familial (N = 14) or sporadic (N = 15) to compare the clinical signs and symptoms between both groups. The familial cases had earlier onset, and gaze paresis was found only in this group. Patients younger than 30 years old were more often familial cases and had more frequent deep sensation involvement. Oculomotor abnormalities on electrooculographic (EOG) tracings of 21 patients were analysed. The defects included abnormal OKN (86%), jerky pursuit (76%), ocular dysmetria (57%), slow saccades (43%), abnormal VOR or VVOR (43%), and fixation instability (19%). Intravenous TRH therapy was used in 17 patients, and resulted in 8 (47%) subjectively and 6 (35%) objectively improved cases. The use of TRH therapy in cerebellar degeneration was discussed.
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PMID:Clinical manifestations and thyrotropin releasing hormone therapy in cerebellar degenerations. 184 43

When a patient with a peripheral monocular paresis is forced to look with the paretic eye, head movements induce the sensation of an unstable visual world. The patient behaves as if he had acute bilateral labyrinthine lesions. These symptoms are due to the lack of compensatory ocular movement and the patients complain that the visual objects move in the direction opposite to the head. The patients develop ataxia, nausea, vomiting and past pointing. The symptoms, however, are transient and consistently disappear after approximately 48 hours. The central adaptation to looking and seeing with the paralysed eye is associated with a plastic change of the VOR. This plastic adaptation is probably induced by the large retinal slip produced by the lack of compensatory movement of the eye and can be studied in the normally mobile eye in the dark. The psychophysical adaptation is probably generated by an efferent copy or corollary discharge of the vestibular system to the visual system that cancels the retinal error.
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PMID:Looking with a paralysed eye: adaptive plasticity of the vestibulo-ocular reflex. 647 Jul 22

To investigate vestibular function in patients with bilateral progressive sensorineural hearing loss (BPSHL), we examined 5 cases using electronystagmography. Cases 1, 2 and 3 were adult type, cases 4 and 5 were juvenile type. All patients had dizzy spells in the early stage of the disease, and showed spontaneous nystagmus. Bilateral reduction of caloric response and very low VOR (vestibulo-ocular reflex) gain on rotation testing were observed in cases 1, 2 and 3. Case 4 showed right canal paresis on the caloric test and left directional preponderance on the rotation test. Case 5 showed good responses to both tests. Optokinetic afternystagmus (OKAN) in cases 2, 3 and 5 was not brisk, and cases 1 and 4 showed directional preponderance of OKAN. Although OKAN is useful for detecting directional preponderance, it does not always reflect peripheral vestibular function. We suggest the existence of two types of BPSHL which correlate with vestibular function. One type is associated with high grade vestibular dysfunction while, in the other, vestibular function is fair.
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PMID:[Vestibular function in bilateral idiopathic progressive sensorineural hearing loss]. 816 43