Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Five adult tigers (Panthera tigris) presented with a range of clinical signs, including paresis (2/5), lameness (2/5), ataxia (3/5), anorexia (5/5), and lethargy (5/5). Each tiger demonstrated elevated plasma globulin levels (7.8-14.8 g/dl; [reference interval 2-5.1 g/dl]) on routine biochemistry, confirmed as a monoclonal gammopathy using protein electrophoresis. Serum gammaglobulin concentration ranged from 5 to 7.5 g/dl, or 45.1-63.4% of total protein concentration. Azotemia was present in three tigers. Diagnostics and management varied with the presenting signs but included magnetic resonance imaging, radiography, chemotherapy, supportive care, and euthanasia. In each case, necropsy revealed a neoplastic plasma cell proliferation in the bone marrow and one or more extramedullary sites. Lytic lesions in the thoraco-lumbar spine were found in three animals, and one lesion was associated with spinal cord compression. Splenomegaly was present in 4/5 cases. Histopathology confirmed a plasma cell neoplasm in each case, and immunohistochemistry staining with multiple myeloma oncogene 1 (MUM1) was positive in each case. CD20 staining was performed in two cases and was positive in one. CD3 staining was performed in the same two cases, and was negative in each. Based on the clinical, gross, microscopic, and immunohistochemical findings, myeloma was diagnosed in all five tigers.
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PMID:HYPERGAMMAGLOBULINEMIA AND MYELOMA IN FIVE TIGERS (PANTHERA TIGRIS): CLINICOPATHOLOGICAL FINDINGS. 3112 Jun 81

A 15-year-old, female cockatoo (Cacatua alba) was presented with a history of intermittent cloacal prolapse of 1-year duration. After each prolapse, the owner would digitally reduce the distended cloacal tissue within approximately 12-24 hours, for short-term resolution. The cockatoo was examined 3 times over a 7-month period and received supportive care with leuprolide acetate, behavioral modification, and diet change. After the third examination, the owner decided to proceed with a surgical cloacopexy. Five days after the last examination and before the procedure was scheduled, the cockatoo was reexamined for acute onset of weakness, anorexia, lethargy, and right-leg paresis. Despite supportive treatment, the cockatoo's clinical condition declined, and it went into respiratory arrest. Resuscitative efforts, including manual ventilation and cardiovascular support, were unsuccessful, and the bird died. Results of postmortem examination revealed vegetative endocarditis with intralesional bacteria cultured as Staphylococcus aureus, right-hindlimb myonecrosis, hepatitis, and nephritis. We suspect that the source of the hematogenous S aureus infection in this cockatoo was translocation from the owner's skin from the repeated manual manipulation and replacement of the prolapsed cloacal tissue.
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PMID:Vegetative Endocarditis due to Staphylococcus aureus in an Umbrella Cockatoo (Cacatua alba). 3183 11


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