Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030552 (
paresis
)
5,831
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The median toxic dose (TD50) of type C botulinum in turkeys was determined using an up-and-down method for toxicologic testing. Birds were dosed intravenously with 10, 20, or 40 mouse lethal dose per kilogram body weight (
MLD
/kg) of type C botulism toxin and observed for 5 days. Administration of toxin resulted in acute death, posterior
paresis
, or no effect, depending upon the dose. The TD50 causing posterior
paresis
was calculated as 25.75
MLD
/kg (confidence interval = 17.08-38.82
MLD
/kg). Posterior
paresis
was identified as the principal sign associated with sublethal botulism toxicosis in turkeys. The resultant posterior
paresis
was similar to the clinical syndrome observed in an unsolved field investigation.
...
PMID:Type C botulism in turkeys: determination of the median toxic dose. 801 88
