Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A nation wide survey demonstrated 129 case of CJD with cadaveric dura mater grafts in Japan to February 2007. These patients were identified to have received Lyodura during period between 1978 and 1991. Incubation period from grafting to the onset of symptoms varied from 16 months to 24.5 years. We conducted a retrospective review of the full medical records of 107 of these patients. Patients were divided into two groups by site of neurosurgical or orthopedic procedures (supratentorial vs. infratentorial). Hemiparesis or hemianopsia developed as an initial manifestation in 31.9% of 47 patients with supratentorial grafts but did not develop among nay of the infratentorial group (p<0.0001). Conversely, brainstem symptoms (nystagmus, diplopia, ipsilateral hearing loss, facial paresis or paresthesia) were noted in 25.0% of the infratentorial group, but were not seen in the supratentorial group (p<0.0001).
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PMID:[Dura mater related Creutzfeldt-Jakob disease in Japan: relationship between sites of grafts and clinical features]. 1769 94