Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Activated protein C resistance in factor V Leiden mutation is currently the most frequent hereditary defect accompanied by high risk of thromboembolism. Thromboembolism often develops in the presence of additional risk factors such as pregnancy, birth, taking oral contraceptives, immobilization and surgical operations. A case of multiple phlebothrombosis following caesarean section in heterozygous factor V Leiden mutation evidenced post partum is reported. The patient developed extensive phlebothrombosis in both legs on postoperative day three despite preventive thrombosis treatment with low-molecular heparin. She also suffered from short-term incomplete paresis of her left arm and epileptic seizure with typical grand mal symptoms. MRI showed partial thrombosis of the superior sagittal sinus and the transverse sinus.
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PMID:[Multiple phlebothrombosis following cesarean section due to heterozygous factor V Leiden mutation detected post partum]. 1061 20

Venous thromboembolism is predominantly a disease of older age. The average annual incidence rate of venous thromboembolism among Caucasians is 1 per 1,000 person-years. Common independent VTE risk factors include hospitalization, active cancer, neurological disease with extremity paresis and, among women, oral contraceptives, pregnancy and the puerperium, and hormone therapy. Inherited reductions in plasma natural anticoagulants (antithrombin, protein C, or protein S) have long been recognized as uncommon but potent risk factors for venous thromboembolism. Activated protein C resistance (factor V Leiden), G20210 variant in the prothrombin gene have been recently added to the list of inherited disorders predisposing to thrombosis. Those latter frequent inherited factors interact with environmental risk factors such as oral contraceptives, pregnancy, hormone therapy.
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PMID:[Incidence and risk factors for venous thromboembolism]. 1762 16