Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We have developed and validated a double-antibody radioimmunoassay for quantifying bovine calcium-binding protein (CaBP). Cross-reactivity between the antiserum and microgram quantities of thyrocalcitonin, calmodulin, gastrin, cholecystokinin, vasoactive intestinal polypeptide, serum albumin and concentrated extract of bovine pituitary gland was insignificant. Slight cross-reactivity (6%) of the antiserum with parathyroid hormone was demonstrated. Assay sensitivity was .25 ng/ml and intraassay and interassay coefficients of variation ranged from 4 to 11% and 10 to 24%, respectively. The CaBP immunoreactivity was not affected by endogenous Ca concentrations. Plasma and serum concentrations of immunoreactive CaBP were similar. The CaBP concentrations were unaffected when coagulated and anticoagulated blood samples were stored at 4 or 22 C for up to 72 h and when serum was stored at -20, 4 or 22 C for 8 d. Serum CaBP concentrations in cattle were not affected by gonadal steroids, but may have been influenced by age. Treatment with 500 mg of vitamin D3, but not 50 mg of dihydrotachysterol, significantly increased serum Ca and CaBP concentrations in Holstein heifers after a lag period of 7 to 10 d. Serum Ca and CaBP concentrations began to increase in serum at approximately the same time and both exhibited parallel responses to treatment with vitamin D3. Serum Ca concentrations were positively correlated (r = .81) with CaBP concentrations and this relationship was described by the equation, Y = 6.85 + 1.01X - .03X2. Serum Ca and CaBP concentrations were still elevated in heifers 75 d after initial treatment with vitamin D3. The radioimmunoassay we describe provides an opportunity to investigate the role of CaBP in Ca homeostasis during growth, pregnancy, lactation, parturient paresis and other physiological and pathological states in cattle.
 ...
PMID:Studies of calcium-binding protein in cattle. 631 69

The protein concentration in the cerebrospinal fluid (CSF) is often increased in patients with sciatica, probably due to leaking of plasma proteins through the blood-nerve root barrier into CSF. Positive straight leg raising test, paresis, altered sensibility, reduced reflexes, and type of treatment were related to the CSF protein concentrations in 180 patients with sciatica caused by verified lumbar disk herniation. Significantly higher values of the CSF/serum albumin ratio and the CSF/serum immunoglobulin G ratio were found both in patients with positive straight leg raising test results and paresis compared with patients with no clinical findings. In the patients who had undergone emergency surgery, the same ratio parameters were significantly higher when compared with those who had undergone routine surgery and those had not undergone surgery. Elevated CSF proteins seem to be important indicators of the functional status of the nerve root and a measure of the degree of seriousness of sciatica. The interaction of smoking on CSF proteins was also studied.
 ...
PMID:Cerebrospinal fluid protein concentrations related to clinical findings in patients with sciatica caused by disk herniation. 818 84

Protein malnutrition occurs in 41%-42% of peritoneal dialysis (PD) patients, indicating that the current intake of protein is inadequate in many patients. With an intake of protein > or = 1 g/kg/day, most continuous ambulatory peritoneal dialysis (CAPD) patients are in positive or neutral nitrogen balance, while with an intake below this there is considerable risk of negative nitrogen balance. Most CAPD patients are prescribed a diet containing 1.2 g/kg/ day protein or higher, yet the majority of patients have an intake lower than this. Several factors are associated with inadequate protein intake including older age, comorbidity, and loss of residual renal function when the dialysis regimen is inadequate. A minimum weekly Kt/V of 2.0 is needed to achieve a protein intake of 0.9-1.0 g/kg/day. Patients with peritonitis and a permeable membrane have increased losses of protein via the dialysate, and so are at risk for protein malnutrition. To prevent and treat protein malnutrition, routine assessment of both nutritional status and dialysis adequacy are needed. Patients with an adequate clearance (weekly Kt/V of 2.0 or higher, creatinine clearance of 60 L/week/1.73 m2), who are eating 1 g/kg/day and have no markers of malnutrition, including a normal serum albumin, require no intervention. Protein supplements can be prescribed to increase the protein ingestion to 1.2 g/kg/day or more, if the serum albumin is low, or if the patient is clinically malnourished with weight loss and decreased muscle mass. Gastro-paresis and esophagitis, common in PD patients, can be treated. If supplements, dietary counseling, and adequate dialysis regimen do not result in improvement of nutritional status, amino acid dialysate may be beneficial. One to two exchanges per day using amino acid dialysate converts the nitrogen balance from neutral to positive in malnourished CAPD patients. To use amino acid dialysate successfully, the physician must be sure that the clearance is adequate as the serum urea nitrogen rises; inadequate dialysis can result in uremia and decreased intake.
 ...
PMID:Recommendations for dietary protein intake in CAPD patients. 886 18

A 79-year-old female presented with cavernous sinus hemangioma manifesting as double vision due to right oculomotor and trochlear nerve pareses. Computed tomography and magnetic resonance imaging revealed bony erosion and a right cavernous sinus tumor with "tail sign" after contrast medium administration. Thallium-201 (201Tl) single photon emission computed tomography (SPECT) showed low uptake within the tumor, and technetium-99m-human serum albumin-diethylenetriaminepenta-acetic acid SPECT disclosed high uptake within the tumor. 201Tl SPECT usually shows very high uptake in meningiomas and malignant tumors, so the tumor was considered to be an unrelated benign tumor. The patient underwent partial resection of the tumor. Histological examination of the specimen confirmed cavernous hemangioma. The oculomotor nerve paresis partially improved. Gamma knife radiosurgery was carried out 4 months after the operation. The tumor markedly shrank with full recovery of extraocular movement 6 months after radiosurgery. SPECT is useful for distinguishing cavernous sinus hemangiomas from other cavernous tumors. Radiosurgery should be performed after partial resection or biopsy for cavernous sinus hemangiomas and may be the initial treatment for patients with small cavernous sinus hemangioma if the diagnosis can be established based on neuroimaging.
 ...
PMID:Cavernous sinus hemangioma treated with gamma knife radiosurgery: usefulness of SPECT for diagnosis--case report. 1110 95