Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The cases of three patients with spinal cord compression who presented with acute urinary retention are discussed. Two patients had previously diagnosed carcinoma; in one, acute urinary retention was the first sign of metastatic renal cell carcinoma. Two patients had a history compatible with prostatic hypertrophy. All had either paresthesias or sensory or motor deficits on initial presentation. All three patients were left with permanent hypotonic bladders. Two patients had permanent lower extremity paresis as well.
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PMID:Acute urinary retention as a presenting sign of spinal cord compression. 375 60

A 62-year-old female patient with metastatic renal cell carcinoma under third-line treatment with pazopanib for 8 weeks suddenly developed severe headaches, grand mal seizures and paresis of the left arm in combination with gait instability as well as nausea and vomiting during her vacation abroad. The emergency physician measured systolic blood pressure values over 300 mm Hg and suspected a stroke. The CT imaging without contrast agent in a local hospital did not show any pathologic findings despite bone metastases. The colleagues suspected cerebral metastases or meningeosis carcinomatosa and referred the patient to our department for further diagnostics and treatment planning. An MRI scan ruled out the suspected cerebral metastases or meningeosis carcinomatosa, but showed signs of reversible posterior leukoencephalopathy syndrome (RPLS) in the form of band-like hyperintensities as a sign of cytotoxic edema in the gray and white matter of the left parietal lobe. The patient then reported that similar blood pressure values had been measured shortly after the start of a first-line therapy with sunitinib, so that we discontinued the current treatment with pazopanib. Within 6 days the neurologic symptoms vanished and the patient was discharged. An intermittent hypertension persisted. A follow-up MRI 3 weeks later showed an RPLS-typical cortical infarction in the affected area. RPLS should be considered as the actual reason for neurologic findings in hypertensive patients with known metastatic cancers under tyrosine kinase inhibitor therapy.
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PMID:Posterior reversible leukoencephalopathy syndrome associated with pazopanib. 2362 62

A 63-year-old man presented with progressive lower-extremity paresis over the previous 3 months. He had been unable to support himself to ambulate over the previous 3 weeks. The patient was found to have metastatic renal cell carcinoma to T11. He underwent robotic assisted percutaneous placement of T9-L1 pedicle screws and open T11 laminectomy/debulking of tumor. This approach allowed for decreased blood loss without the need for preoperative embolization. After decompression and placement of the hardware, the patient regained the ability to ambulate on his own. The video can be found here: https://youtu.be/BTFQezhZlB4 .
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PMID:Navigated robotic assisted thoracic pedicle screw placement for metastatic renal cell carcinoma. 2996 15