Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 50 patients with lumbar nucleus pulposus prolapse the force of femoral abductors was determined by the test of Lovett and by means of dynamometric measurements. In 90% of patients paresis of these muscles was found. A comparison of the incidence of other signs of nerve root damage such as paresis of plantar and dorsal flexion of the foot and toes, sensory impairment on the foot and lack or weakness of ankle jerk showed that paresis of fermoral abductors was most frequent among them. This fact is explained by a particular predisposition for development of uncleus pulposus prolapse at the level of 4th and 5th intervertebral discs with resulting injury to the nerve roots L4, L5, and S1 innervating femoral abductors. The authors think that paresis of femoral abductors may be a pathognomonic sign in the diagnosis of nerve root lesions caused by nucleus prolapse at the levels L4-L5 or L5-S1. The frequency of paresis and the degree of weakness indicate the necessity of motor rehabilitation of this music group in comprehensive treatment of patients with lumbar disc prolapse.
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PMID:[Force of femoral abductors in patients with lumbar nucleus pulposus prolapse]. 115 63

A prospective study was carried out in 280 patients suffering from sciatica caused by myelographically verified disc prolapse. The patients were divided into three groups according to the following criteria: 1. The doubtful group, selected at random. Patients with doubtful indications for surgery. Treated operatively or not--by drawing lots. 2. Non-operated group. Patients with moderate symptoms and/or continued improvement. 3. Operated group. Patients with imperative indications for surgery. The muscle strength of the lower limbs was measured during maximal isometric voluntary contractions in all the patients 2 weeks after admission. Approximately 50 per cent had paresis. Control examinations of these patients 1 year later showed that operative treatment gave no better prognosis than conservative treatment with regard to the motor function, neither in the group chosen at random nor in the selected groups. The causative factors are discussed.
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PMID:The effect of delayed disc surgery on muscular paresis. 118 24

The consequences of signs of emergency compression of cauda equina in combination with a normal lumbar myelography are reported in 19 patients. Two of them had a tumor and a herniated disc, respectively, in the thoracic spine discovered by a second myelography. One patient was considered to have a hysterical paresis. In 3 patients the symptoms were attributed to diseases not related to the spine. Thirteen patients recovered spontaneously. We conclude that the prognosis for patients with signs of compression of the cauda equina is favorable provided the myelography is normal; surgical exploration is then not indicated. However, if severe unexplained symptoms persist and computed tomography is normal, myelography of the thoracic spine should be considered.
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PMID:Cauda equina syndrome with normal lumbar myelography. 275 Apr 97

A Hansen type I cervical intervertebral disc prolapse was diagnosed in a 16-year-old American Saddler showing clinical signs of paresis and ataxia. An ante-mortem diagnosis was made by means of plain radiographs and a myelogram. The horse was euthanased and the diagnosis confirmed on a post-mortem examination.
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PMID:[Cervical intervertebral disk prolapse in a horse]. 336 56

This discourse is aimed at elucidating prognostic criteria for the assessment of the course of a paresis in the case of lumbar disc herniation. Fourhundred and fifty patients were examined who had been operated on for lumbar disc herniation at the Orthopaedic University Clinic Mainz between 1986 and 1991. Of these, 240 showed radicular paralytic symptoms. They were examined prior to the operation, immediately afterwards and 1 year after the operation. The influence of the degree of intensity of the paresis, the time elapsed since the occurrence and other factors like nerve root affected, intraoperative findings, age, sex and weight of the patient were registered. It is obvious that the degree of intensity of a paresis is a good prognostic criterion for the assessment of the postoperative course. A paresis classified as grade III or IV receded in more than 70% of the cases within 6 months. For a paresis of grade II, the recovery rate was 40%. In the case of a total paresis, no complete neurological recovery was registered. The period of time which had elapsed since the occurrence of the paresis, the weight of the patient, the nerve root affected and other factors did not show any significant influence. As a criterion for an emergency or postponed operation on a herniated disc, the duration of paralytic symptoms should therefore be attributed less importance than the progression.
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PMID:Prognostic criteria of discogenic paresis. 786 38

A consensus development meeting concerning the treatment of lumbosacral radicular syndrome (LRS) by entrapment by a herniated disc or spinal stenosis was held on June 9th, 1995. It was observed that there is a lack of good evidence on many aspects of diagnosis and treatment of LRS. Agreement was reached on the thesis that the natural course of LRS is often benign. Diagnosis and treatment can usually be left to the primary care physician. Specialist consultation and ancillary investigations are only needed if an operation is indicated or in case of persistent diagnostic uncertainty. If imaging is needed MRI is preferred to CT or myelography. MRI is highly sensitive, but less specific, and may thus give false-positive results. Neurophysiologic testing may be informative in selected cases. Plain spinal X-rays are not useful in most cases. The traditional non-invasive treatments (such as bedrest, traction, physiotherapy, spinal manipulation) are not based upon convincing scientific evidence. Diagnostic imaging and invasive treatment should be considered in patients with a severe LRS that does not improve within a 4 to 8 week period. Both discectomy and chemonucleolysis are effective treatments. The principal indication is incapacitating radicular pain. There is no sound evidence that the prognosis of paresis is improved by operation. A cauda equina syndrome urgently needs surgical treatment. The efficacy of percutaneous interventions (nucleotomy, laser therapy) has not been proven. There are no strategies for the primary or secondary prevention of LRS that have demonstrated their efficacy. Psychological, social and financial factors probably contribute significantly to the occurrence of persisting symptoms after a LRS. Advice not to work after treatment for LRS may impede rehabilitation.
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PMID:[Consensus on diagnosis and treatment of the lumbosacral radicular syndrome. Dutch Society for Neurology]. 902 41

The aim of this study is to evaluate the prognosis of motor function in patients that experience the combination of a sudden disappearance of radicular pain and severe motor paresis. Eight patients were identified over a ten year period. Operative decompression of the affected lumbar root with removal of a disc prolapse seems to have a good prognosis if the patient is not paralytic before surgery. Patients treated conservatively for radicular pain should be advised to call their doctor immediately if they experience progressive motor paresis and diminishing pain.
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PMID:[Incarceration of spinal nerve roots]. 907 55

Percutaneous laser discectomy (PLD) was performed in 273 patients with herniated disc-induced lumbosacral radiculitis. Indications for PLD were based on clinical and neurological findings and results of MR tomography: no benefit from conservative treatment, pain syndrome in the lumbago stage and sciatica not presenting with severe paresis and with herniated intervertebral discs down to 6 mm in size across.
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PMID:[Laser puncture diskectomy in discogenic lumbosacral radiculitis]. 962 42

Intervertebral disc herniation (IVDH) is a common cause of spinal cord injury (SCI) in dogs. Microtubule-associated protein tau derives predominantly from neurons and axons, making it a potential marker of neuronal injury. A retrospective study, including 51 dogs with thoracolumbar or cervical IVDH and 12 clinically normal dogs, was designed to describe associations between cerebrospinal fluid (CSF) tau concentration, degree of neurological signs and motor functional recovery in dogs with IVDH. Signalment, degree of neurological dysfunction and outcome were recorded. Cisternal CSF tau values were determined by ELISA. Associations between CSF tau concentration and various clinical parameters were evaluated. Receiver-operating characteristics curve (ROC) analyses were performed to assess the validity of protein tau measurements. CSF tau concentrations were significantly higher in dogs showing plegia (median, 79.9 pg/mL; range, 0-778.7 pg/mL; P=0.016) compared to healthy dogs and dogs with paresis (median, 30.1 pg/mL; range, 0-193.1 pg/mL; P=0.025). Plegic dogs that improved by one neurological grade within 1 week had significantly lower tau protein levels compared to plegic dogs that needed more time for recovery or did not show an improvement (P=0.008). A CSF tau concentration >41.3 pg/mL had a sensitivity of 86% and specificity of 83% to predict an unsuccessful outcome in plegic dogs based on ROC analysis (area under the curve, 0.887; P=0.007, 95% confidence interval [CI] 0.717-1.057). CSF protein tau levels are positively associated with the severity of spinal cord damage and may serve as a prognostic indicator in dogs with IVDH.
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PMID:Cerebrospinal fluid tau protein as a biomarker for severity of spinal cord injury in dogs with intervertebral disc herniation. 2376 57

A 33-year-old man presented with moderate low-back pain and L-5 radiculopathy that progressed to severe paresis of L-5. On initial imaging, a corresponding spinal lesion was overlooked. Further CT and contrast-enhanced MRI demonstrated a presacral mass along the L-5 root far extraforaminally. A herniated disc was suspected, but with standard imaging a schwannoma could not be ruled out. The presacral L-5 root was explored via a microsurgical lateral extraforaminal transmuscular approach. To the best of the authors' knowledge, there have been no reports of sequestered extraforaminal lumbosacral disc herniations that herniated into the presacral region.
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PMID:Far caudally migrated extraforaminal lumbosacral disc herniation treated by a microsurgical lateral extraforaminal transmuscular approach: case report. 2663 61


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