Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two patients suffering from aneurysms of the internal carotid artery simulating pituitary tumours are reported. One of these was a 17-year-old boy with a mycotic aneurysm of the right internal carotid artery causing failure of growth and pubertal maturation. The second was a 53-year-old woman with a left internal carotid artery aneurysm, probably of atherosclerotic origin, who had evidence of anterior pituitary insufficiency.In both cases there was paresis of extraocular muscles and one patient had bitemporal hemianopsia. While lateral radiographs of the skull suggested intrasellar calcification in each case, further roentgenological investigation established that this calcification was actually extrasellar, and carotid arteriograms demonstrated the presence of an internal carotid aneurysm in each case. Investigations of the endocrine system confirmed the presence of anterior pituitary insufficiency in both patients, and diabetes insipidus became evident in one patient after cortisone therapy was commenced.This lesion, while rare, may be difficult to differentiate from a pituitary tumour. It is likely that this syndrome depends on aneurysmal expansion to the region of the sella turcica with compression of the pituitary gland itself, as well as the optic fibres.
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PMID:Aneurysms of the internal carotid artery simulating pituitary tumours. Report of two cases. 536 39

A 15-year-old diabetic boy suffering from recurrent peritonsillar infections developed a mycotic aneurysm of the internal carotid artery at the base of the skull. The aneurysm was approached through a cervical and retroauricular incision. The styloid process was burred down at its base. The sternocleidomastoid muscle and the digastric muscle were resected from the mastoid. The internal carotid artery was clamped proximally and blocked with a balloon-catheter distally. The carotid bone canal was opened 10 mm and the carotid artery resected until normal vessel wall was reached. A vein graft was placed end-to-end with single stitches, using 8 X 0 monofil sutures with a small needle. The postoperative course was uneventful except for a temporary paresis of the peripheral facial nerve. Postoperative angiography revealed restoration of the vessel to normal, the patient is now free of symptoms.
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PMID:[Aneurysm of the internal carotid artery at the base of the skull (author's transl)]. 689 13

Lemierre's syndrome is characterized by anaerobic septicemia, internal jugular vein thrombosis, and septic emboli associated with infections of the head and neck. We describe an unusual and clinically confusing case of a young woman with an acute paresis of the abducens nerve and partial paresis of the right oculomotor nerve. After an extensive imaging diagnostic procedure, we also documented a peritonsillar abscess and various types of thromboses in intracranial and extracranial veins. Furthermore, we found brain and lung abscesses, which led us to establish the diagnosis of Lemierre's syndrome. Despite intensive anti-coagulation and antibiotic therapy, the patient developed a mycotic aneurysm in the right internal carotid artery directly adjacent to the previously thrombosed cavernous sinus. In summary, we were able to confirm that Lemierre's syndrome may occur in conjunction with uncharacteristic symptoms. Due to the sometimes confusing clinical symptoms as well as clinical and radiological specialties, we had to work on an interdisciplinary basis to minimize the delay prior to establishing the diagnosis and therapy.
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PMID:Differential diagnosis of Lemierre's syndrome in a patient with acute paresis of the abducens and oculomotor nerves. 2373 Jan 18