Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Central pontine myelinolysis (CPM) is a demyelinating disease of the pons often associated with the demyelination of extrapontine areas of the central nervous system. Although the etiology and pathogenesis are unclear, CPM is usually associated with hyponatremia or its rapid correction, and chronic alcoholism is also a common underlying condition. We observed a 43-year-old man with diabetes mellitus who developed central pontine and extrapontine myelinolysis with no apparent evidence of hyponatremia, serum hyperosmolality or associated rapid correction, or history of alcohol abuse. On admission, the patient was lethargic with dysarthria, dysphagia, and mild tetraparesis and his face and lower extremities were severely edematous. Laboratory examination showed normoglycemia and normonatremia, although hypokalemia, elevated HbA1c, and nephrotic syndrome were also present. Magnetic resonance imaging (MRI) revealed abnormal signal intensity in the pons, the deep layers of the cerebral cortex, and the adjacent white matter consistent with central pontine and extrapontine myelinolysis. Generalized edema was reduced by the use of diuretics and extracorporeal ultrafiltration without significant changes of serum sodium or osmolality. His consciousness level and paresis gradually improved within a few weeks. Our patient is a rare case of CPM associated with diabetes without apparent evidence of sodium or glucose imbalances.
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PMID:Central pontine and extrapontine myelinolysis associated with type 2 diabetic patient with hypokalemia. 1581 68

Strokes among young people are not only the most threatening complications of the cerebrovascular diseases, but they also lead to considerable disability and society' dependency. Among patients under 40 years old heart diseases constitute about 18% causes of ischaemic strokes. Other causes of strokes are: artery wall dissection, blood clotting disturbances, birth control pills, stimulants (alcohol abuse, cigarettes, narcotics), vascular immunological diseases. Among these causes there are modifiable factors, which can be eliminated through patients' education, change of the lifestyle and proper treatment of diseases. In paper there is presented the case of 22-year-old woman, who had in the first hours after delivery the paresis of left limbs with paresis of left facial nerve, proceded by loss of consciousness and convulsions. In computer tomography (CT) and magnetic resonance imaging (MRI) there was extensive angiogenic lesion in the area of right internal cervical artery revealed in duplex ultrasonography. In transesophageal echocardiography (TEE) there was revealed haemodynamically significant patent foramen ovale (PFO). In the patient in ten months after stroke there was performed diagnostic cathetarization and then transvascular occlusion of PFO using Starflex 28 mm implant. The patient was rehabilitated from the early time after stroke. Based on carried out examination results that the most likely hypothesis seems to be embolic-thrombotic stroke in the course of hemodynamically significant heart defect (paradoxical embolism in patent foramen ovale) revealed in drastic way during delivery. The earlier lasted process of dissection of cervical internal right artery cannot be also excluded as a cause of stroke.
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PMID:[Stroke in young woman in the first day after delivery]. 1681 81

Chronic alcoholic myopathy occurs in 40-60% of patients who abuse alcohol, and is accompanied by decreased performance, proximal paresis and atrophy of skeletal muscles. However, it is unknown what is important in the development of the disease: duration of alcohol abuse, or the dose of ethanol consumed. Unknown dynamics of the pathological process in skeletal muscle. We examined male patients identified with alcoholic myopathy and without it, evaluated the duration of alcohol abuse, intake of ethanol, morphological characteristics m.quadriceps vastus lateralis and the content of IGF-1 in plasma. It has been shown that chronic alcoholic myopathy develops after 10 years of alcohol abuse; proximal paresis is observed only in patients with atrophy of muscle fibers, thus there is a transformation of myosin phenotype from slow to fast. The decrease IGF-1 in plasma detected at the early stages of the Church, including in patients without clinical manifestations of proximal paresis and morphological signs of atrophy of muscle fibers.
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PMID:[The Development of Clinical and Morphological Manifestations of Chronic Alcoholic Myopathy in Men with Prolonged Alcohol Intoxication]. 2685 89