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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This paper reports the effects of supplementation of the diet with linoleic acid on the severity of experimental allergic encephalomyelitis (EAE) in guinea pigs. Clinical signs of disease (e.g. paresis, paraplegia, urinary incontinence), weight loss, frequency of perivascular lesions in the central nervous system and ability of isolated lymph node cells to respond to myelin basic protein in vitro were all reduced by linoleic acid supplementation. Linoleic acid was effective when fed at a dose of 0.5 ml/day from 7 to 21 days after sensitization of the animals with basic protein, i.e., before and during the time in which clinical signs normally appeared. The same daily dose fed from 7 days before to 7 days after sensitization, i.e., ceasing about 7 days before the normal time of appearance of clinical signs, produced no significant effect. Feeding linoleic acid to normal guinea pigs significantly altered the fatty acid composition of their serum and lymph nodes, but not of their brain. Of several possible explantations for the protective effect of lineolic acid in EAE, we considered action by this essential fatty acid on the immune system most likely.
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PMID:Reduction by linoleic acid of the severity of experimental allergic encephalomyelitis in the guinea pig. 63 36

During the period from January 1st 1983 up to the end of April 1989 in the Neurology Department and the Neurosurgery Department 1417 patients were treated due to subarachnoidal hemorrhage. Among these patients in 275 cases the inner hydrocephalus was diagnosed using computer tomography (19.4%). In 17 cases (6.2%) hydrocephalus was treated surgically. In all patients the ventricle-atrial Pudenz valve was implanted; in 15 patients the valve was implanted for low pressure and in 2 for moderate pressure. The diagnostics was based on the computed tomography and angiography of cerebral vessels. In all cases large hydrocephalus was diagnosed (the anterior horn index in the computed tomography was below 3.0). The most frequent clinical symptoms were: urine incontinence (15 cases), disturbances of orientation (8 cases), akinetic mutism (8 cases) and paresis of extremities (7 cases). Above symptoms together with radiologic image presented indication for the valve implantation. Very good and good results were obtained in 13 patients, bad results in 2 cases, 2 patients died. Longer observation showed that 6 patients remain in satisfactory state, 3 patients are in bad state and 3 others died.
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PMID:[Immediate and late results of surgical treatment of hydrocephalus after subarachnoid hemorrhage]. 208 43

Twenty eight patients with the clinical diagnosis of idiopathic late onset cerebellar ataxia were examined clinically and by magnetic resonance imaging (MRI) or computed tomography (CT). In addition, the clinical records of all patients were analysed retrospectively. On the basis of their clinical presentation they were subdivided into patients with a pure cerebellar syndrome (n = 9) and patients with a cerebellar syndrome and additional non-cerebellar symptoms (n = 13). No attempts were made to classify patients with a disease duration of less than four years (n = 6) because the retrospective analysis showed that the disease started almost invariably with a pure cerebellar syndrome and additional symptoms came later. Patients with a lasting pure cerebellar syndrome had a significantly better prognosis than patients with additional non-cerebellar involvement (annual progression rate rate: 0.40 versus 0.80). Calculated median lifetime from onset of symptoms was 20.7 years in patients with a pure cerebellar syndrome and 7.7 years in patients with additional non-cerebellar symptoms. Among the latter, disease progression was faster the earlier non-cerebellar symptoms occurred. All of them presented with Parkinsonian symptoms, whereas bulbar symptoms, vertical gaze paresis, pyramidal deficits, dementia and urinary incontinence were encountered less frequently. MRI or CT showed cerebellar atrophy without apparent involvement of brainstem structures in all patients with a pure cerebellar syndrome suggesting the diagnosis of cerebellar cortical atrophy (CA). The majority of the patients with additional non-cerebellar symptoms had evidence of an atrophy of the cerebellum and the brainstem suggesting the presence of olivo-ponto-cerebellar atrophy (OPCA). In two of them, however, MRI morphology was not compatible with the diagnosis of OPCA.
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PMID:Idiopathic cerebellar ataxia of late onset: natural history and MRI morphology. 234 43

A retrospective investigation was undertaken to investigate which factors are of significance in recommendation of patients with cerebral apoplexy in geriatric departments to nursing homes. The investigation includes 116 patients admitted during a period of two years. Thirty-five (30%) were recommended for nursing homes. Sixty-seven (58%) remained severely handicapped (corresponding to Rankin's groups IV and V). Logistic regression analysis revealed that marital status, dementia, lack of motivation and inability to walk were associated with recommendation for nursing homes whereas sex, degree of paresis, aphasia, focal cognitive disturbances, incontinence of urine and hemianopsia did not show any association. Sex was, similarly, of no significance for the functional result of rehabilitation. On the basis of the regression analysis, the probability of recommendation to a nursing home may be calculated with knowledge of the predisposing factors in any given patient.
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PMID:[Referral of elderly patients with cerebral apoplexy to nursing homes]. 239 77

A patient developed weakness in the upper limbs, eventually causing brachial diplegia with only slight paresis of the legs after rapid correction of severe hyponatraemia. Pseudobulbar palsy, mental confusion and urinary incontinence were also present. CT scan showed a zone of lucency in the pons. Clinical recovery occurred and the zone of lucency had disappeared 12 months after the appearance of the neurological signs.
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PMID:Brachial diplegia in central pontine myelinolysis. 397 43

Twelve Lewis rats were inoculated with a guinea pig spinal cord tissue preparation. They developed experimental allergic encephalomyelitis (EAE) after 12-14 days, manifested by weight loss, tail flaccidity, ataxia, hind limb paresis and incontinence. The CNS lesions are produced in this animal model on the basis of inflammatory demyelination, which provides a useful model for multiple sclerosis. Concomitantly with EAE, all animals developed vestibular hyperreactivity (VH) of otolith and canal reflexes. In surviving animals these reflexes renormalized after full clinical recovery. The major effect on the canal response was an increased duration of postrotatory nystagmus caused by an increase in time constant. These findings are similar in part to those previously reported in patients with multiple sclerosis.
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PMID:Physiological abnormalities in experimental allergic encephalomyelitis (EAE). I. Vestibular hyperreactivity (VH) in rats with EAE. 633 52

12 Lewis rats were inoculated with a guinea pig spinal cord tissue preparation. They developed experimental allergic encephalomyelitis (EAE) after 12-14 days manifested by weight loss, tail flaccidity, ataxia, hind limb paresis or paralysis and urinary incontinence. Concomitantly with EAE, all animals developed vestibular hyperreactivity (VH) of canal and otolith reflexes. Other signs of brain-stem dysfunction were also observed: abducens paralysis, facial weakness, tachypnoe and mydriasis with defective pupillary light reflex. The vestibular and other abnormalities subsided with some delay after recovery from clinical EAE, whilst histological abnormalities were still present in the CNS.
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PMID:Physiological abnormalities in experimental allergic encephalomyelitis (EAE): II. Correlation between clinical signs and vestibular hyperreactivity and other signs of brain-stem dysfunction in rats with EAE. 633 24

Comprehensive treatment, including pharmacotherapy, rehabilitation, psychotherapy and ultrasound stimulation of the lymphatic system by the method of Seltzer is given to multiple sclerosis patients at the hospital department for these patients. In the first year of treatment three courses of ultrasound sessions are given with 24 sessions in each course, in the second year two such courses are given, and in the following years one course is given yearly. The present material comprised 45 patients after 7 or 8 courses of treatment in the hospital. The neurological status of each patient was evaluated before the first course and after the last one using a score scale containing the most important clinical parameters. Is was found that these therapeutic methods had only a negligible effect on paresis of the extremities, but it seems that they influenced favourably eye signs, particularly nystagmus, and cerebellar tremor. The greatest improvement was obtained in sphincter disturbances, especially in pollakiuria and urinary incontinence. The effect of ultrasound alone on the obtained results could not have been assessed. Investigations would be necessary for this purpose which are not done in this hospital.
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PMID:[Complex treatment of patients with multiple sclerosis]. 664 25

A chronic, progressive form of experimental allergic encephalomyelitis was produced by immunization of rabbits with bovine brain white matter proteolipid apoprotein. Clinical signs appeared 4 to 13 months after sensitization, and were characterized by ataxia and limb paresis which progressed to flaccid paralysis and incontinence. Light and electron microscopic observations showed both acute and chronic nonsuppurative myelitis or encephalomyelitis accompanied by primary demyelination. Myelin damage was most evident in the spinal cord but was also present in the optic nerve and brain. The neuropathology was consistent with lesions of chronic experimental allergic encephalomyelitis produced by central nervous system tissue, and resembled lesions of multiple sclerosis as well. These observations suggest that protein may be involved in the pathophysiology of demyelinating diseases. A mechanism for the chronic course of the disease is discussed.
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PMID:Chronic experimental allergic encephalomyelitis induced in rabbits with bovine white matter proteolipid apoprotein. 710 65

Following an embolic occlusion of a major cerebral artery with peripheral migration of emboli in the early stage, cerebral haemorrhage from the recanalized perforators may occur in the infarcted zone. The following is a report of such a case. This 66-year-old-man with normotension suffered from sudden unconsciousness and left-sided paresis. On admission to our clinic five hours after onset, the patient was confused with urinary incontinence, left hemiplegia and irregular pulse. The first CT examination, which was performed immediately after admission, showed a small-sized haematoma surrounded by an obscure broad low density area in the region of the right caudate nucleus. Right carotid angiography which was performed after CT scan revealed an occlusion at the trifurcation level of the right middle cerebral artery and extravasation of contrast media from the right lenticulostriate arteries. Because of deterioration of the patient's condition, a second CT scan was done showing an extensive haematoma in the whole basal ganglionic region with ventricular rupture. An emergency decompressive craniectomy with evacuation of the haematoma was carried out with immediate postoperative improvement of the patient's condition. Judging from the mode of onset, clinical course as well as neuroradiological and preoperative findings, the pathogenesis behind the haemorrhagic infarction could be interpreted as follows: At the onset, a thromboembolic occlusion probably occurred in the right internal carotid artery with lack of sufficient collateral circulation. Before or during the first CT examination, the embolus may have migrated to the middle cerebral artery. Therefore, the reflow in the perforating arteries in the head of the caudate nucleus could have led to a haemorrhage in the infarcted area. Furthermore, the insufficiency of the lenticulostriate arteries expressed by extravasation of contrast media might be due to the high pressure reflow of the ischaemic vessels with increased permeability after further peripheral migration of the embolus. As a result, a huge and extensive haemorrhage took place in the infarcted area in the basal-ganglionic region. This phenomenon may be identical with the so-called "haemorrhagic infarction".
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PMID:[Extravasation of contrast media in an acute stage of middle cerebral artery occlusion-in relation to haemorrhagic infarction (author's transl)]. 725 6


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