Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 7 year old boy presented with sudden lower extremity paresis six months after resection of a Wilms' tumor. Roentgenologic studies showed destruction of the sixth vertebral body and a thoracic extradural block by an epidural mass subsequently proven to be a solitary Wilms' metastasis.
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PMID:Solitary spinal metastasis from Wilms' tumor. 624 34

A 1-year-old Irish wolfhound was presented with a history of slowly progressive left pelvic limb paresis. A neurological examination demonstrated bilateral deficits referable to the thoracolumbar spinal cord. Lumbar cerebrospinal fluid contained neoplastic cells. An intradural, extramedullary mass was demonstrated by myelography at the caudal aspect of T13. Surgical excision was abandoned owing to severe macroscopic damage to, and apparent infiltration of, the cord, and the dog was euthanased. The tumour was diagnosed histologically as an extrarenal nephroblastoma. Nephroblastoma should be suspected in young, large-breed dogs with intradural extramedullary masses over spinal segments T10-L2. The prognosis for complete recovery after surgical excision is guarded to poor.
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PMID:Spinal nephroblastoma in an Irish wolfhound. 1085 19

A 1-year-old, female intact Shetland sheepdog presented with acute onset of neurological signs. Physical examination revealed a large abdominal mass. Neurological examination revealed multifocal disease with neck pain, short-strided forelimbs, and hind-limb paresis with loss of tail and anal tone. Blood work, imaging techniques, cytopathology, and histopathology led to a diagnosis of renal, bone-marrow, and extradural spinal nephroblastoma. This report documents potential clinical and pathological manifestations of canine nephroblastoma that have not been previously reported.
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PMID:Extradural spinal, bone marrow, and renal nephroblastoma. 1254 19

A three-year-old, male crossbreed dog presented with progressive hindlimb paresis. Magnetic resonance imaging revealed an intramedullary spinal cord lesion of 1.5 cm diameter at the levels of the first and second lumbar vertebrae. Following surgical excision of the mass, there was resolution of the neurological signs. Twelve months later, hindlimb paresis was again evident. A second surgical procedure restored ambulatory status for a further five months before signs recurred and the dog was euthanased. A diagnosis of spinal nephroblastoma was made on the basis of signalment, lesion location and histopathological analysis of biopsy specimens.
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PMID:Spinal nephroblastoma in a crossbreed dog. 1516 56

A 2-year-old castrated miniature Dachshund dog was presented to the Rakuno Gakuen Veterinary Teaching Hospital for diagnosis of progressive hindlimb paresis and ataxia. There was no thoracolumbar intervertebral disk hernia and magnetic resonance imaging revealed an intramedullary spinal cord lesion at the ninth and tenth thoracic vertebrae. Following surgical excision of the neoplasm, there was minor amelioration of neurological signs, but forelimb function was not recovered. The extracted tumor was histopathlogically diagnosed as spinal nephroblastoma.
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PMID:Spinal nephroblastoma in a miniature Dachshund. 1721 16

An 8-month-old male Bernese Mountain Dog was referred with a history of hindlimb weakness that progressed to paresis on the right side. An intradural mass was detected in the spinal canal at the level of the 2nd and 3rd lumbar vertebrae. During surgical removal, 2 small fragments of the mass were prepared for cytologic examination by the squash technique. Cytologic examination revealed 3 different cell types: mesenchymal (stromal) cells, epithelial cells, and small undifferentiated hyperchromatic cells. On the basis of location and the triphasic cytologic pattern, a diagnosis of spinal nephroblastoma (thoracolumbar spinal tumor of young dogs) was made; histologic examination of the mass confirmed the cytologic diagnosis. To our knowledge, this is the first report of a triphasic pattern in a cytologic sample; recognizing this pattern is an important aid in reaching a definitive cytologic diagnosis.
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PMID:A true "triphasic" pattern: thoracolumbar spinal tumor in a young dog. 1752 97

A 7-month-old intact male Otterhound was presented for diagnosis of progressive hindlimb paresis. The neurological examination revealed a severe ambulatory paraparesis localised to the left-sided region of the lower motor neuron (L4-S1). Magnetic resonance imaging was suggestive for an intradural-extramedullary neoplasia at the fifth lumbar vertebra. Surgical exploration demonstrated an intradural-extramedullary mass, which partially invaded the spinal cord. The mass was removed with the exception of the intramedullar part, and the diagnosis of a nephroblastoma was made histopathologically. Following radiation therapy, the dog fully recovered and displayed no signs of neurological dysfunction 9 months after surgery.
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PMID:[Spinal nephroblastoma at an uncommon localization in a dog]. 2820 68

A 1-year-old male mixed breed dog presented for the evaluation of progressive hindlimb paresis. Neurological examination indicated a spinal cord lesion between the 3rd thoracic and 3rd lumbar vertebrae. Magnetic resonance imaging (MRI) revealed an intramedullary spinal cord lesion located at the level of the 1st and 2nd lumbar vertebrae. Following cytoreductive surgery of the mass, palliative radiation therapy was administered. A diagnosis of nephroblastoma was made based on histological examination. After radiation therapy, the disappearance of the spinal lesion was confirmed by MRI. The dog was improved from gait abnormality and alive at 16 months postoperatively, with slight signs of neurological dysfunction.
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PMID:Intramedullary spinal nephroblastoma in a mixed breed dog. 3241 35