Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030552 (paresis)
 5,831 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 15-year-old girl suffering from acute dermatomyositis was treated with cyclosporin A after conventional therapy had failed. During this treatment there was a marked decrease of the myolysis and improvement of the paresis.
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PMID:[Treatment of an acute dermatomyositis with cyclosporin A]. 653 45

A case of dermatomyositis (DM) with only one abnormal muscle function, bilateral diaphragmatic paresis, is reported. The coexistence of interstitial lung disease allowed us to sample the diaphragm during an open lung biopsy. Characteristic features of myositis were found. Lung volumes, compliance, maximal inspiratory pressure, and transdiaphragmatic pressure gradient (delta Pdi) were lower than normal. Lung recoil pressure was normal. Reversible small airways obstruction was also found. Treatment with prednisone produced dramatic improvement, with all functional values becoming normal except for compliance, which remained slightly decreased. A thorough evaluation of inspiratory muscle strength is advised in all patients with DM in order to identify varying degrees of altered diaphragmatic function.
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PMID:Isolated bilateral diaphragmatic paresis with interstitial lung disease. An unusual presentation of dermatomyositis. 669 31

We reported a 50-year-old man with an overlap syndrome of dermatomyositis and SLE, whose magnetic resonance image of the brain showed a rapidly increasing large tumor-like focal lesion unequally enhanced by Gd-DTPA in the left frontal lobe. Its pathological finding by the brain biopsy was fibrinoid necrosis, inflammatory cell aggregation around blood vessels and many myelin-laden macrophages with central necrosis. Although many cases of blood vessel injury are reported in CNS lupus, in this case the brain lesion partly took reversible course and neural symptoms such as paresis were slight and the lesion well responded to steroid. Moreover we considered that the measurement of serum anti-ribosomal P and CSF antineuronal antibodies are useful to diagnose cases as CNS lupus.
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PMID:[Overlap syndrome of systemic lupus erythematosus and dermatomyositis presented a large demyelinating subcortical lesion mimicking brain tumor and high level of CSF antineuronal and serum anti-ribosomal P antibodies]. 1247 87

Mixed connective tissue disease (MCTD) is a chronic autoimmune disease, which has a broad range of clinical manifestations shared by systemic lupus erythematosus, systemic sclerosis, polymyositis/dermatomyositis, and rheumatoid arthritis. MCTD is featured with high serum titers of anti-ribonucleoprotein antibodies and multiple system involvement. Its spinal cord involvement mainly manifests as transverse myelopathy (TM) and longitudinal extensive transverse myelopathy (LETM). Myelopathy in MCTD is extremely rare, and is usually characterized by serious neurological complications, such as paralysis or muscular paresis, sensory impairment, and smooth muscle dysfunction. Progressive clinical manifestations combined with laboratory examinations and magnetic resonance imaging examinations play important roles in the diagnosis of this disease. In order to prevent permanent neurological damage to the spinal cord, plasmapheresis and intravenous immunoglobulin can be performed in patients at the early disease stage. Early high-dose corticosteroids combined with cyclophosphamide, followed by low doses of immunosuppressors, can improve the long-term prognosis of patients. There are only nine global cases reported on MCTD associated with myelopathy at present. The death rate and disability rate of myelopathy in MCTD are extremely high. In this review, the pathomechanisms, clinical manifestations, auxiliary examination, diagnosis, differential diagnosis, treatment, and prognosis of myelopathy in MCTD were systematically elucidated.
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PMID:Myelopathy associated with mixed connective tissue disease: clinical manifestation, diagnosis, treatment, and prognosis. 3111 2