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Enzyme
Compound
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Target Concepts:
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Query: UMLS:C0030305 (
pancreatitis
)
16,014
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Interleukin-22
(
IL-22
) (also reported as IL-10-related T cell-derived inducible factor, IL-TIF) is a recently identified cytokine found to signal through a receptor comprising the class II cytokine receptor family members IL-10Rbeta/CRF2-4 and IL-22R. Previous work has established that IL-10Rbeta, also a component of the IL10R complex, exhibits a broad distribution of mRNA expression. Here, we observe that IL-22R exhibits a restricted expression pattern, with highest levels of mRNA expression in pancreas and detectable expression in multiple other tissues, particularly liver, small intestine, colon, and kidney. We find that isolated primary pancreatic acinar cells and the acinar cell line 266-6 respond to
IL-22
with activation of Stat3 and changes in gene transcription.
IL-22
mediates robust induction of mRNA for pancreatitis-associated protein (PAP1)/Reg2 and osteopontin (OPN). PAP1 is a secreted protein related to the Reg family of trophic factors and was initially characterized as a protein elevated in
pancreatitis
. In vivo injection of
IL-22
resulted in rapid induction of PAP1 in pancreas, a response not observed in mice deficient in IL-10Rbeta. These results support the conclusion that IL-10Rbeta is a required common component of both the IL-10 and
IL-22
receptors and suggest that
IL-22
may play a role in the immune response in pancreas.
...
PMID:Acinar cells of the pancreas are a target of interleukin-22. 1179 62
Interleukin-22
(
IL-22
) is involved in the development of lymphocytes and serves as a rapid and early source of the effector cytokines that are released in response to pathogen-induced changes in the microenvironment. Recent research has implicated
IL-22
as a potential contributing factor to the spectrum of inflammation-related pancreatic diseases, particularly
pancreatitis
, fibrosis, carcinoma and diabetes. In this review, we summarize the current knowledge on the roles of
IL-22
in the various pancreatic pathogenesis, providing insights into the underlying cellular and signaling mechanisms that will help guide future research into promising interventional targets with therapeutic potential.
...
PMID:Diverse effects of interleukin-22 on pancreatic diseases. 2950 86
