Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030305 (
pancreatitis
)
16,014
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
From its discovery as a phosphatidylethanolamine-binding protein in bovine brain to its designation as a physiological inhibitor of Raf kinase protein,
RKIP
has emerged as a critical molecule for maintaining subdued, well-orchestrated cellular responses to stimuli. The disruption of
RKIP
in a wide range of pathologies, including cancer, Alzheimer's disease, and
pancreatitis
, makes it an exciting target for individualized therapy and disease-specific interventions. This review attempts to highlight recent advances in the
RKIP
field underscoring its potential role as a master modulator of many pivotal intracellular signaling cascades that control cellular growth, motility, apoptosis, genomic integrity, and therapeutic resistance. Specific biological and functional niches are highlighted to focus future research towards an enhanced understanding of the multiple roles of
RKIP
in health and disease.
...
PMID:RKIP: much more than Raf kinase inhibitory protein. 2335 13
