Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030305 (
pancreatitis
)
16,014
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The mechanisms of injury and regeneration after acute pancreatitis are still incompletely understood. Insulin-like growth factor binding proteins (IGFBPs) have been reported to play roles in various pancreatic diseases, but the involvement of
insulin-like growth factor binding protein-4
(
IGFBP-4
) in acute pancreatitis is unknown. The aim of the study was to examine the expression of
IGFBP-4
in mice with acute pancreatitis induced by two doses of L-arginine.
IGFBP-4
expression was assayed by microarray test, real-time RT-PCR, Western blotting, ELISA and by an immunohistochemical assay. Microarray test of pancreatic mRNA showed that
IGFBP-4
mRNA increased significantly after L-arginine treatment and the increase was confirmed by real-time RT-PCR. Western blotting and ELISA assay showed similar patterns of increase of
IGFBP-4
in pancreatic tissues and serum. In the control pancreas,
IGFBP-4
was mainly immunolocalized in the pancreatic islets. In the pancreatic tissues of mice with
pancreatitis
induced by L-arginine, the immunolocalization of
IGFBP-4
was detected in both acinar cells and pancreatic islets. In conclusion, our results suggest that
IGFBP-4
may play a potential role in pancreatic injury and regeneration in a murine model of acute pancreatitis induced by L-arginine.
...
PMID:Expression of insulin-like growth factor binding protein-4 (IGFBP-4) in acute pancreatitis induced by L-arginine in mice. 2183 95
