Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0030305 (
pancreatitis
)
16,014
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The serine/threonine kinase Mst1 plays important roles in the control of immune cell trafficking, proliferation, and differentiation. Previously, we reported that Mst1 was required for thymocyte selection and regulatory T-cell functions, thereby the prevention of autoimmunity in mice. In humans,
MST1
null mutations cause T-cell immunodeficiency and hypergammaglobulinemia with autoantibody production. RASSF5C(RAPL) is an activator of
MST1
and it is frequently methylated in some tumors. Herein, we investigated methylation of the promoter regions of
MST1
and RASSF5C(RAPL) in leukocytes from patients with IgG4-related autoimmune
pancreatitis
(AIP) and rheumatoid arthritis (RA). Increased number of CpG methylation in the 5' region of
MST1
was detected in AIP patients with extrapancreatic lesions, whereas AIP patients without extrapancreatic lesions were similar to controls. In RA patients, we detected a slight increased CpG methylation in
MST1
, although the overall number of methylation sites was lower than that of AIP patients with extrapancreatic lesions. There were no significant changes of the methylation levels of the CpG islands in the 5' region of RASSF5C(RAPL) in leukocytes from AIP and RA patients. Consistently, we found a significantly down-regulated expression of
MST1
in regulatory T cells of AIP patients. Our results suggest that the decreased expression of
MST1
in regulatory T cells due to hypermethylation of the promoter contributes to the pathogenesis of IgG4-related AIP.
...
PMID:Hypermethylation of MST1 in IgG4-related autoimmune pancreatitis and rheumatoid arthritis. 2605 43
