Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0030305 (pancreatitis)
 16,014 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The incidence of postoperative hyperamylasaemia was evaluated in 70 patients who underwent staged restorative proctocolectomy. On the 14th postoperative day, 27 of 70 patients after total colectomy showed hyperamylasaemia, and the serum amylase returned to normal on the 30th postoperative day. Three out of 37 after ileoanal anastomosis and 8 out of 70 after stoma closure showed elevation of serum amylase postoperatively. Total colectomy might have a possible role in the postoperative increase of serum amylase. None of these patients had any obvious clinical evidence of postoperative pancreatitis. In 7 patients showing significant elevation of serum amylase levels (over 1000 IU), this was due predominantly to the pancreatic isoenzyme. This transitory elevation of serum amylase did not seem to be altered by the administration of therapeutic agents for pancreatitis. These observations suggest that postoperative hyperamylasaemia without clinical evidence of pancreatitis is very common after total colectomy, and that postoperative hyperamylasaemia itself does not necessarily require treatment.
Int J Colorectal Dis 1992 Dec
PMID:Transitory elevation of serum amylase levels after restorative proctocolectomy. 128 76

The role of mycobacterial heat shock proteins (Hsp) of the 65 kilodalton Hsp family as a possible factor governing cell-mediated immune responses, leading to chronic mucosal inflammation, was examined. Purified peripheral blood mononuclear cells (PBMC) from patients with CD and ulcerative colitis (UC), and from healthy and disease controls were stimulated in culture with a highly purified, recombinant 65 kilodalton Hsp (rHsp65) of M. bovis BCG for 5 d. Cultures were then pulsed with 3H-thymidine for 24 h and uptake determined by liquid scintillation. We found that PBMC from patients with active CD exhibited a significant proliferative response to the soluble rHsp65 as compared with normal controls. In contrast, the proliferative responses of PBMC from patients with inactive CD, inactive and active UC, pancreatitis and cecal carcinoma were found to be not different from controls. Purified T cells or non-T cells of PBMC in the absence of antigen-presenting cells from active CD patients exhibited a lack of proliferative responses to the rHsp65 stimulation in culture. The data indicate an aberrant sensitization of T cells to the 65 kilodalton mycobacterial Hsp in a specific type of IBD, and thus may provide an important clue for the etiopathogenesis of Crohn's disease.
Clin Invest Med 1992 Dec
PMID:Evidence for T lymphocyte reactivity to the 65 kilodalton heat shock protein of mycobacterium in active Crohn's disease. 128 31

Acute hemorrhagic pancreatitis was induced in Wistar rats using a retrograde intraductal injection of 5% Na-taurocholate. Rats were sacrificed at 1, 3, 6, and 24 h. Malondialdehyde and sulfhydryl groups concentration, as well as superoxide dismutase and catalase activity were measured in pancreatic, liver, and lung tissue. These parameters, with the exception of catalase, were also determined in serum and peritoneal exudate. Early and profound oxidative stress in each organ was evidenced by marked increases in malondialdehyde concentrations along with marked reductions in levels of sulfhydryl groups and superoxide dismutase; a paradoxical increase in catalase activity, perhaps compensatory, was noted in pancreas and lung. Survival for 24 h was associated with restoration of normality insofar as tissue malondialdehyde concentrations were concerned, but pancreas sulfhydryl groups remained markedly depleted. These data endorse the suggestion that the early provision of such compounds may help to accelerate recovery from hemorrhagic pancreatitis in humans.
Int J Pancreatol 1992 Dec
PMID:Oxidative stress. An early phenomenon characteristic of acute experimental pancreatitis. 128 14

Two male patients with complications associated with chronic pancreatitis are described. In each patient, preoperative examinations revealed a large stone obstructing the main duct in the head of the pancreas. Lateral pancreaticojejunostomy was performed to relieve pain and prevent further attacks of pancreatitis. During each operation, the stone was fragmented under direct visual control with the use of a flexible choledochoscope and a contact electrohydraulic lithotriptor. The stone was removed and ductal flow through the head of the pancreas was reestablished. Our experience shows that endoscopic electrohydraulic lithotripsy facilitates operative removal of pancreatic stones deeply located in the head of the pancreas.
Int J Pancreatol 1992 Dec
PMID:Intraoperative endoscopic electrohydraulic lithotripsy of pancreatic stones. 128 15

A total of 160 Japanese patients with pancreatic carcinoma were treated in the Department of Surgery I, Kyushu University Faculty of Medicine, Fukuoka, Japan, from January 1976 to December 1991. Four of these patients had an accompanying pancreatic calcification with a 2.5% incidence of pancreatic carcinoma. Those four patients consisted of 52, 75, 75, and 82 year-old men. Three complained of jaundice and another developed an abdominal mass. Two of the four patients were diabetic and had a past history of heavy alcoholic intake. Three pancreatic carcinomas were located in the head of the pancreas, including two with multiple small calcifications in the entire pancreas and one with a solitary large calcification in the head. Another pancreas body carcinoma was associated with diffuse small calcifications both in and distal to the mass. In three pancreatic carcinomas, pancreatic calcification was demonstrated proximal and distal to the pancreatic carcinomas. All four patients died within 14 months after the clinical diagnosis of pancreatic carcinoma. Although we cannot draw a definitive conclusion on the link because of the limited number of cases in this retrospective study, followup studies on patients with chronic calcifying pancreatitis are needed for clarification.
Int J Pancreatol 1992 Dec
PMID:Pancreatic carcinoma associated with chronic calcifying pancreatitis. 128 22

Of 20 patients treated for pancreatic abscess during the years 1984-1991, two patients were found to have adenocarcinoma of the pancreas associated with their pancreatic abscesses. In one patient an adenocarcinoma of the proximal pancreas caused ductal obstruction, which may have been the primary cause of an abscess distal to the tumor. In the second patient, metastatic adenocarcinoma of the pancreas and a concurrent pancreatic abscess were found when the patient's abdomen was explored for complications related to gallstone pancreatitis. In both patients, the tumor was unresectable at presentation. A detailed review of these cases is presented as well as a review of the related literature.
Int J Pancreatol 1992 Dec
PMID:Adenocarcinoma of the pancreas coexisting with pancreatic abscess. 128 24

Percutaneous instrumentation under fluoroscopic control via the T tube tract is a minimally invasive technique to remove retained bile duct stones after cholecystectomy. 23 of 25 patients were treated successfully with this method. Two patients needed either percutaneous transhepatic stone-removal or repeat surgery because his residual calculus could neither be removed percutaneously nor endoscopically. In standard situations, the calculi were removed quickly and easily under outpatient conditions. Impacted and large calculi had to be mobilized and fragmented prior to their removal. One patient developed fever, another a mild, transient pancreatitis, no serious complications were observed. In large series, the success rate is 86-95%, the complication rate 3-5%, and the mortality rate 0-0.1%. A relative drawback of the percutaneous technique is the waiting period of approximately 4 weeks which is required for tract maturation. However, this inconvenience is acceptable if we consider that the risk of the percutaneous procedure is less than with endoscopic retrograde sphincterotomy. Therefore, we still favour a primary percutaneous radiologic approach to remove retained bile duct stones.
Bildgebung 1992 Dec
PMID:[Percutaneous removal of residual calculi of the bile ducts by T-drainage tract]. 129 68

Postoperative T Tube cholangiographies of 311 patients from 1980 to February 1992 were evaluated by studying the patient histories and x-ray examinations. Most frequent questions concerned residual stones and papillary occlusion. Most frequent pathological findings were dilatation of the choledochus and of the bile ducts, residual stones and paravasations. Fistulas, abscesses and signs of cholangitis rarely occurred. Dilatation of the choledochus alone did not lead to further treatment. Papillary occlusion was treated by leaving the T drain in situ, patients with occlusion and residual stones were treated by papillotomy, litholysis or lithotripsy. Only 5 patients with necrotizing pancreatitis and abscess had to be reoperated. T tube cholangiography, which at the beginning of the study was a routine postoperative control with minor complications, will surely be applied less frequently in the future due to advances in endoscopy.
Bildgebung 1992 Dec
PMID:[Roentgen findings in T-drainage--results of 311 patients]. 129 69

Caerulein-induced acute pancreatitis was studied in rats. Consistent with this type of acute pancreatitis morphological (edema, leukocytic infiltration and acinar cell vaculization) and biochemical (increase in pancreatic protein content. PAF release and serum amylase) changes developed 5 hours after caerulein administration. In addition increase in pancreatic weight and decrease in pancreatic blood flow were noticed. PAF administration caused pancreatic damage similar in some parameters to caerulein-induced pancreatitis, along with reduction of pancreatic blood flow, increase in pancreatic protein content, and serum amylase. TCV-309, a selective PAF antagonist, administered prior to caerulein and/or PAF, reduced caerulein-induced pancreatitis and prevented PAF-induced pancreatitis. Results of our present studies indicate the crucial role of PAF in pathogenesis of experimental acute pancreatitis.
J Physiol Pharmacol 1992 Dec
PMID:Platelet activating factor (PAF) inhibitor (TCV-309) reduces caerulein- and PAF-induced pancreatitis. A morphologic and functional study in the rat. 129 65

The study of a 70-year-old woman with fibrosing pancreatitis, an uncommon variety of chronic pancreatitis, presenting as a discrete solid mass in the head of the pancreas, is reported. CT and US were non-diagnostic while ERCP and MR detected a focal anomaly. This case report stresses the sensitivity of MR in some pancreatic pathologies.
J Belge Radiol 1992 Dec
PMID:Chronic focal fibrosing pancreatitis: detection by MRI. 129 79


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